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[Enhancing effect of Ulex europaeus agglutinin I modified liposomes on oral insulin absorption in mice].
Yao Xue Xue Bao. 2004 Dec; 39(12):1006-10.YX

Abstract

AIM

To investigate the enhancing effect on insulin absorption through GI. tract in mice by using the Ulex europaeus agglutinin I (UEA1) modified liposomes as the carrier.

METHODS

UEA1 modified phosphatidylethanolamine (PE) was prepared by conjugating method of 1-ethyl-3-(3'-dimethylaminopropyl) carbodiimide (EDC), then the modified compound (PE-UEA1) was incorporated into the conventional liposomes of insulin to obtain UEA1 modified liposomes. The agglutination test was performed to examine the UEA1 biological activities after synthesis and modification. When liposomes were applied to healthy mice or diabetic mice at insulin dose of 350 u x kg(-1) orally, the hypoglycemic effect was investigated according to the blood glucose level determination.

RESULTS

The blood glucose levels of the healthy mice reduced by UEA1 modified liposomes were (84 +/- 15)% at 4 h, (78 +/- 11)% at 8 h and (90 +/- 12)% at 12 h after oral administration. The conventional liposomes and saline showed no effect. The blood glucose levels of the diabetic mice reduced by UEA1 modified liposomes were (73 +/- 7)% at 4 h, (74 +/- 9)% at 8 h, (86 +/- 9)% at 12 h after oral administration.

CONCLUSION

The UEA1 modified liposomes promote the oral absorption of insulin due to the specific-site combination on M cell membrane.

Authors+Show Affiliations

China Pharmaceutical University, Nanjing 210009, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15813031

Citation

Zhang, Na, et al. "[Enhancing Effect of Ulex Europaeus Agglutinin I Modified Liposomes On Oral Insulin Absorption in Mice]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 39, no. 12, 2004, pp. 1006-10.
Zhang N, Ping QN, Xu WF. [Enhancing effect of Ulex europaeus agglutinin I modified liposomes on oral insulin absorption in mice]. Yao Xue Xue Bao. 2004;39(12):1006-10.
Zhang, N., Ping, Q. N., & Xu, W. F. (2004). [Enhancing effect of Ulex europaeus agglutinin I modified liposomes on oral insulin absorption in mice]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 39(12), 1006-10.
Zhang N, Ping QN, Xu WF. [Enhancing Effect of Ulex Europaeus Agglutinin I Modified Liposomes On Oral Insulin Absorption in Mice]. Yao Xue Xue Bao. 2004;39(12):1006-10. PubMed PMID: 15813031.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Enhancing effect of Ulex europaeus agglutinin I modified liposomes on oral insulin absorption in mice]. AU - Zhang,Na, AU - Ping,Qi-neng, AU - Xu,Wen-fang, PY - 2005/4/9/pubmed PY - 2005/12/15/medline PY - 2005/4/9/entrez SP - 1006 EP - 10 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 39 IS - 12 N2 - AIM: To investigate the enhancing effect on insulin absorption through GI. tract in mice by using the Ulex europaeus agglutinin I (UEA1) modified liposomes as the carrier. METHODS: UEA1 modified phosphatidylethanolamine (PE) was prepared by conjugating method of 1-ethyl-3-(3'-dimethylaminopropyl) carbodiimide (EDC), then the modified compound (PE-UEA1) was incorporated into the conventional liposomes of insulin to obtain UEA1 modified liposomes. The agglutination test was performed to examine the UEA1 biological activities after synthesis and modification. When liposomes were applied to healthy mice or diabetic mice at insulin dose of 350 u x kg(-1) orally, the hypoglycemic effect was investigated according to the blood glucose level determination. RESULTS: The blood glucose levels of the healthy mice reduced by UEA1 modified liposomes were (84 +/- 15)% at 4 h, (78 +/- 11)% at 8 h and (90 +/- 12)% at 12 h after oral administration. The conventional liposomes and saline showed no effect. The blood glucose levels of the diabetic mice reduced by UEA1 modified liposomes were (73 +/- 7)% at 4 h, (74 +/- 9)% at 8 h, (86 +/- 9)% at 12 h after oral administration. CONCLUSION: The UEA1 modified liposomes promote the oral absorption of insulin due to the specific-site combination on M cell membrane. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/15813031/[Enhancing_effect_of_Ulex_europaeus_agglutinin_I_modified_liposomes_on_oral_insulin_absorption_in_mice]_ DB - PRIME DP - Unbound Medicine ER -