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Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector.
J Forensic Sci. 2005 Mar; 50(2):326-35.JF

Abstract

The recent emergence of a new class of piperazine-type compounds has brought about the need for laboratory screening methods for both seized drugs and toxicological samples. These piperazine compounds, which include 1-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)piperazine (TFMPP), exhibit comparable physiological effects and can be substituted for the classic amphetamine-type drugs. We have optimized a chiral capillary electrophoresis (CE) separation that detects a set of 6 piperazine and 4 chiral amphetamine compounds in under 23 min using a 200 mM phosphate buffer at a pH = 2.8 with 20 mM hydroxypropyl- beta-cyclodextrin (HPbeta3CD). In addition to the above compounds, a series of "clandestine" BZP diHCl samples were also analyzed using this method to assess the ruggedness of the procedure. The novel CE separation was tailored to simultaneously detect these piperzine compounds in addition to amphetamine-type drugs. Distinct migration time and UV-spectral data were obtained for all compounds of interest.

Authors+Show Affiliations

Ohio University, Department of Chemistry and Biochemistry, 136 Clippinger Laboratories, Athens OH 45701, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15813543

Citation

Bishop, Sandra C., et al. "Simultaneous Separation of Different Types of Amphetamine and Piperazine Designer Drugs By Capillary Electrophoresis With a Chiral Selector." Journal of Forensic Sciences, vol. 50, no. 2, 2005, pp. 326-35.
Bishop SC, McCord BR, Gratz SR, et al. Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector. J Forensic Sci. 2005;50(2):326-35.
Bishop, S. C., McCord, B. R., Gratz, S. R., Loeliger, J. R., & Witkowski, M. R. (2005). Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector. Journal of Forensic Sciences, 50(2), 326-35.
Bishop SC, et al. Simultaneous Separation of Different Types of Amphetamine and Piperazine Designer Drugs By Capillary Electrophoresis With a Chiral Selector. J Forensic Sci. 2005;50(2):326-35. PubMed PMID: 15813543.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous separation of different types of amphetamine and piperazine designer drugs by capillary electrophoresis with a chiral selector. AU - Bishop,Sandra C, AU - McCord,Bruce R, AU - Gratz,Samuel R, AU - Loeliger,Jill R, AU - Witkowski,Mark R, PY - 2005/4/9/pubmed PY - 2005/4/20/medline PY - 2005/4/9/entrez SP - 326 EP - 35 JF - Journal of forensic sciences JO - J. Forensic Sci. VL - 50 IS - 2 N2 - The recent emergence of a new class of piperazine-type compounds has brought about the need for laboratory screening methods for both seized drugs and toxicological samples. These piperazine compounds, which include 1-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)piperazine (TFMPP), exhibit comparable physiological effects and can be substituted for the classic amphetamine-type drugs. We have optimized a chiral capillary electrophoresis (CE) separation that detects a set of 6 piperazine and 4 chiral amphetamine compounds in under 23 min using a 200 mM phosphate buffer at a pH = 2.8 with 20 mM hydroxypropyl- beta-cyclodextrin (HPbeta3CD). In addition to the above compounds, a series of "clandestine" BZP diHCl samples were also analyzed using this method to assess the ruggedness of the procedure. The novel CE separation was tailored to simultaneously detect these piperzine compounds in addition to amphetamine-type drugs. Distinct migration time and UV-spectral data were obtained for all compounds of interest. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/15813543/Simultaneous_separation_of_different_types_of_amphetamine_and_piperazine_designer_drugs_by_capillary_electrophoresis_with_a_chiral_selector_ DB - PRIME DP - Unbound Medicine ER -