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Early childhood environment related to microbial exposure and the occurrence of atopic disease at school age.
Allergy. 2005 May; 60(5):619-25.A

Abstract

BACKGROUND

There is a growing body of evidence that the early childhood environment with respect to day care attendance, older siblings, pet ownership, and early life airway infections may protect from developing atopic disease. Few studies have distinguished between atopic sensitization and symptoms, and none have evaluated independent contributions for all of these different environmental conditions.

OBJECTIVE

Examine independent effects on atopic sensitization and symptoms of day care attendance, older siblings, pet ownership, and early infancy's airway disease.

METHODS

A cross-sectional survey among 8-13-year-old school children with complete data for 1555 children.

RESULTS

After adjustment for confounders, atopic sensitization occurred less frequently in children that had attended a day care centre (OR: 0.73, 95% CI: 0.55-0.98) or had a cat or dog before 2 years of age (OR: 0.78, 95% CI: 0.61-0.99). Having older siblings yielded a nonsignificant trend towards protection (OR: 0.88, 95% CI: 0.70-1.11). For symptoms, there was no relation with having older sibs, day care attendance and pet ownership, although there was a trend towards protection for the combination of atopy and symptoms. In contrast, children with doctors' treated airway disease before age 2, more frequently reported recent symptoms of wheeze, asthma, rhinitis, or dermatitis (all P < 0.05).

CONCLUSION

Early life environmental exposure to day care, or pets may protect against atopic sensitization. Protection against symptoms only occurred if atopic sensitization was present as well.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, Environmental and Occupational Health, Utrecht University, Utrecht, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15813806

Citation

de Meer, G, et al. "Early Childhood Environment Related to Microbial Exposure and the Occurrence of Atopic Disease at School Age." Allergy, vol. 60, no. 5, 2005, pp. 619-25.
de Meer G, Janssen NA, Brunekreef B. Early childhood environment related to microbial exposure and the occurrence of atopic disease at school age. Allergy. 2005;60(5):619-25.
de Meer, G., Janssen, N. A., & Brunekreef, B. (2005). Early childhood environment related to microbial exposure and the occurrence of atopic disease at school age. Allergy, 60(5), 619-25.
de Meer G, Janssen NA, Brunekreef B. Early Childhood Environment Related to Microbial Exposure and the Occurrence of Atopic Disease at School Age. Allergy. 2005;60(5):619-25. PubMed PMID: 15813806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early childhood environment related to microbial exposure and the occurrence of atopic disease at school age. AU - de Meer,G, AU - Janssen,N A H, AU - Brunekreef,B, PY - 2005/4/9/pubmed PY - 2005/8/20/medline PY - 2005/4/9/entrez SP - 619 EP - 25 JF - Allergy JO - Allergy VL - 60 IS - 5 N2 - BACKGROUND: There is a growing body of evidence that the early childhood environment with respect to day care attendance, older siblings, pet ownership, and early life airway infections may protect from developing atopic disease. Few studies have distinguished between atopic sensitization and symptoms, and none have evaluated independent contributions for all of these different environmental conditions. OBJECTIVE: Examine independent effects on atopic sensitization and symptoms of day care attendance, older siblings, pet ownership, and early infancy's airway disease. METHODS: A cross-sectional survey among 8-13-year-old school children with complete data for 1555 children. RESULTS: After adjustment for confounders, atopic sensitization occurred less frequently in children that had attended a day care centre (OR: 0.73, 95% CI: 0.55-0.98) or had a cat or dog before 2 years of age (OR: 0.78, 95% CI: 0.61-0.99). Having older siblings yielded a nonsignificant trend towards protection (OR: 0.88, 95% CI: 0.70-1.11). For symptoms, there was no relation with having older sibs, day care attendance and pet ownership, although there was a trend towards protection for the combination of atopy and symptoms. In contrast, children with doctors' treated airway disease before age 2, more frequently reported recent symptoms of wheeze, asthma, rhinitis, or dermatitis (all P < 0.05). CONCLUSION: Early life environmental exposure to day care, or pets may protect against atopic sensitization. Protection against symptoms only occurred if atopic sensitization was present as well. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/15813806/Early_childhood_environment_related_to_microbial_exposure_and_the_occurrence_of_atopic_disease_at_school_age_ L2 - https://doi.org/10.1111/j.1398-9995.2005.00746.x DB - PRIME DP - Unbound Medicine ER -