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Normalization of oesophageal pH does not guarantee control of duodenogastro-oesophageal reflux in Barrett's oesophagus.
Aliment Pharmacol Ther. 2005 Apr 15; 21(8):969-75.AP

Abstract

BACKGROUND

Proton-pump inhibitors are effective at preventing the acid component of gastro-oesophageal refluxate from entering the oesophagus. It is not clear whether proton-pump inhibitors prevent duodenogastro-oesophageal reflux.

AIM

To measure oesophageal exposure to duodenogastro-oesophageal refluxate while on proton-pump inhibitors in patients with Barrett's oesophagus.

METHODS

Twenty-five patients (23 male) with Barrett's oesophagus underwent 24 h oesophageal pH and Bilitec 2000 monitoring while on omeprazole 40 mg/day (n = 19) or omeprazole 60 mg/day (n = 6). All patients were undergoing argon plasma ablation of their Barrett's epithelium as part of a clinical trial and the Bilitec measurements were only carried out after the ablation had been completed.

RESULTS

20 of 25 (80%) patients had a normal oesophageal pH profile. Fifteen of the 25 (60%) had abnormal oesophageal exposure to bile as measured by Bilitec 2000. Of the 20 patients who had a normal 24 h oesophageal pH profile, 11 (55%) had pathological exposure to bile in their oesophagus.

CONCLUSION

Complete acid suppression does not guarantee elimination of duodenogastro-oesophageal reflux.

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    Authors+Show Affiliations

    Todd JA
    Digestive Diseases Centre, University Hospitals of Leicester NHS Trust, Gwendolen Road, Leicester LE5 4PW, UK.
    Basu KK
    No affiliation info available
    de Caestecker JS
    No affiliation info available

    MeSH

    AgedAnti-Ulcer AgentsBarrett EsophagusDuodenal DiseasesEsophagoscopyEsophagusFemaleGastric AcidGastroesophageal RefluxHumansHydrogen-Ion ConcentrationMaleMiddle AgedOmeprazoleProton Pump Inhibitors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15813832

    Citation

    Todd, J A., et al. "Normalization of Oesophageal pH Does Not Guarantee Control of Duodenogastro-oesophageal Reflux in Barrett's Oesophagus." Alimentary Pharmacology & Therapeutics, vol. 21, no. 8, 2005, pp. 969-75.
    Todd JA, Basu KK, de Caestecker JS. Normalization of oesophageal pH does not guarantee control of duodenogastro-oesophageal reflux in Barrett's oesophagus. Aliment Pharmacol Ther. 2005;21(8):969-75.
    Todd, J. A., Basu, K. K., & de Caestecker, J. S. (2005). Normalization of oesophageal pH does not guarantee control of duodenogastro-oesophageal reflux in Barrett's oesophagus. Alimentary Pharmacology & Therapeutics, 21(8), 969-75.
    Todd JA, Basu KK, de Caestecker JS. Normalization of Oesophageal pH Does Not Guarantee Control of Duodenogastro-oesophageal Reflux in Barrett's Oesophagus. Aliment Pharmacol Ther. 2005 Apr 15;21(8):969-75. PubMed PMID: 15813832.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Normalization of oesophageal pH does not guarantee control of duodenogastro-oesophageal reflux in Barrett's oesophagus. AU - Todd,J A, AU - Basu,K K, AU - de Caestecker,J S, PY - 2005/4/9/pubmed PY - 2005/7/6/medline PY - 2005/4/9/entrez SP - 969 EP - 75 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 21 IS - 8 N2 - BACKGROUND: Proton-pump inhibitors are effective at preventing the acid component of gastro-oesophageal refluxate from entering the oesophagus. It is not clear whether proton-pump inhibitors prevent duodenogastro-oesophageal reflux. AIM: To measure oesophageal exposure to duodenogastro-oesophageal refluxate while on proton-pump inhibitors in patients with Barrett's oesophagus. METHODS: Twenty-five patients (23 male) with Barrett's oesophagus underwent 24 h oesophageal pH and Bilitec 2000 monitoring while on omeprazole 40 mg/day (n = 19) or omeprazole 60 mg/day (n = 6). All patients were undergoing argon plasma ablation of their Barrett's epithelium as part of a clinical trial and the Bilitec measurements were only carried out after the ablation had been completed. RESULTS: 20 of 25 (80%) patients had a normal oesophageal pH profile. Fifteen of the 25 (60%) had abnormal oesophageal exposure to bile as measured by Bilitec 2000. Of the 20 patients who had a normal 24 h oesophageal pH profile, 11 (55%) had pathological exposure to bile in their oesophagus. CONCLUSION: Complete acid suppression does not guarantee elimination of duodenogastro-oesophageal reflux. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15813832/Normalization_of_oesophageal_pH_does_not_guarantee_control_of_duodenogastro_oesophageal_reflux_in_Barrett's_oesophagus_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02406.x DB - PRIME DP - Unbound Medicine ER -