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Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats.
J Ethnopharmacol. 2005 Apr 26; 98(3):245-50.JE

Abstract

The aim of this study was to examine the possible antioxidant activities of wild Panax ginseng leaf extract intake in streptozotocin (STZ)-induced diabetic rats (WGLE). Initial blood glucose levels increased abruptly after streptozotocin injection. After 4 weeks of WGLE supplementation, blood glucose levels were lower in animals fed 40 mg/kg (266 mg/dL) and 200 mg/kg (239 mg/dL) than those in no-WGLE fed diabetic rats (464 mg/dL). The concentration of blood TBARS, which are considered the main products of glucose oxidation in blood, was also lowered by WGLE supplementation. These results indicate that WGLE supplementation is involved in suppressing a sudden increase in blood glucose levels and a consequent decrease in TBARS levels in diabetic rats. TBARS levels in the liver, kidney and spleen of WGLE-fed diabetic groups were also significantly lower than in the control diabetic group indicating that oral administration of WGLE effectively suppresses lipid peroxidation that occurs in the organs of diabetic rats. Antioxidant activities of WGLE supplementation further extend in suppressing activities of antioxidant related enzymes, such as glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), in organs of diabetic rats. These results confirm the effectiveness of WGLE supplementation in detoxifying free radicals that are produced excessively in diabetic-induced complications.

Authors+Show Affiliations

Korea Food Research Institute, San 46-1, Baekhyun-dong, Bundang-ku, Songnam-si, Kyunggi-do 463-746, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15814255

Citation

Jung, Chang-Hwa, et al. "Effects of Wild Ginseng (Panax Ginseng C.A. Meyer) Leaves On Lipid Peroxidation Levels and Antioxidant Enzyme Activities in Streptozotocin Diabetic Rats." Journal of Ethnopharmacology, vol. 98, no. 3, 2005, pp. 245-50.
Jung CH, Seog HM, Choi IW, et al. Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. J Ethnopharmacol. 2005;98(3):245-50.
Jung, C. H., Seog, H. M., Choi, I. W., Choi, H. D., & Cho, H. Y. (2005). Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. Journal of Ethnopharmacology, 98(3), 245-50.
Jung CH, et al. Effects of Wild Ginseng (Panax Ginseng C.A. Meyer) Leaves On Lipid Peroxidation Levels and Antioxidant Enzyme Activities in Streptozotocin Diabetic Rats. J Ethnopharmacol. 2005 Apr 26;98(3):245-50. PubMed PMID: 15814255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of wild ginseng (Panax ginseng C.A. Meyer) leaves on lipid peroxidation levels and antioxidant enzyme activities in streptozotocin diabetic rats. AU - Jung,Chang-Hwa, AU - Seog,Ho-Moon, AU - Choi,In-Wook, AU - Choi,Hee-Don, AU - Cho,Hong-Yon, PY - 2004/05/17/received PY - 2004/12/09/revised PY - 2004/12/13/accepted PY - 2005/4/9/pubmed PY - 2005/7/21/medline PY - 2005/4/9/entrez SP - 245 EP - 50 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 98 IS - 3 N2 - The aim of this study was to examine the possible antioxidant activities of wild Panax ginseng leaf extract intake in streptozotocin (STZ)-induced diabetic rats (WGLE). Initial blood glucose levels increased abruptly after streptozotocin injection. After 4 weeks of WGLE supplementation, blood glucose levels were lower in animals fed 40 mg/kg (266 mg/dL) and 200 mg/kg (239 mg/dL) than those in no-WGLE fed diabetic rats (464 mg/dL). The concentration of blood TBARS, which are considered the main products of glucose oxidation in blood, was also lowered by WGLE supplementation. These results indicate that WGLE supplementation is involved in suppressing a sudden increase in blood glucose levels and a consequent decrease in TBARS levels in diabetic rats. TBARS levels in the liver, kidney and spleen of WGLE-fed diabetic groups were also significantly lower than in the control diabetic group indicating that oral administration of WGLE effectively suppresses lipid peroxidation that occurs in the organs of diabetic rats. Antioxidant activities of WGLE supplementation further extend in suppressing activities of antioxidant related enzymes, such as glutathione peroxidase (GSH-Px), catalase (CAT) and superoxide dismutase (SOD), in organs of diabetic rats. These results confirm the effectiveness of WGLE supplementation in detoxifying free radicals that are produced excessively in diabetic-induced complications. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15814255/Effects_of_wild_ginseng__Panax_ginseng_C_A__Meyer__leaves_on_lipid_peroxidation_levels_and_antioxidant_enzyme_activities_in_streptozotocin_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00061-9 DB - PRIME DP - Unbound Medicine ER -