Tags

Type your tag names separated by a space and hit enter

Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models.
J Ethnopharmacol. 2005 Apr 26; 98(3):267-73.JE

Abstract

In this study, the anti-inflammatory, analgesic, and antipyretic effects of 50, 100 and 200 mg/kg body weight of methanol extract obtained from Bauhinia racemosa stem bark, the so-called MEBR, were investigated. The effects of MEBR on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin)-induced paw oedema and cotton pellet-induced granuloma, respectively. Analgesic effect of MEBR was evaluated in acetic acid-induced writhing and hotplate tests. Antipyretic activity of MEBR was evaluated by yeast-induced hyperpyrexia in rats. The anti-oedema effect of MEBR was compared with 10 mg/kg of indomethacin orally. In acute phase of inflammation, a maximum inhibition of 44.9, 43.2, 44.8 and 45.9% (P<0.001) was noted at the dose of 200 mg/kg b.w. after 3h of treatment with MEBR in carrageenan, dextran, histamine and serotonin-induced paw oedema, respectively. Administration of MEBR (200 mg/kg b.w.) and indomethacin (10 mg/kg b.w.) significantly (P<0.05) decreased the formation of granuloma tissue induced by cotton pellet method at a rate of 50.4 and 56.2%, respectively. The extract also inhibited peritoneal leukocyte migration in mice. The MEBR also produced significant (P<0.01) analgesic activity in both models. Further, the MEBR potentiated the morphine- and aspirin-induced analgesic in mice. Treatment with MEBR showed a significant (P<0.01) dose-dependent reduction in pyrexia in rats. The results suggest that MEBR possess potent anti-inflammatory, analgesic and antipyretic activity.

Authors+Show Affiliations

Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15814258

Citation

Gupta, M, et al. "Anti-inflammatory, Analgesic and Antipyretic Effects of Methanol Extract From Bauhinia Racemosa Stem Bark in Animal Models." Journal of Ethnopharmacology, vol. 98, no. 3, 2005, pp. 267-73.
Gupta M, Mazumder UK, Kumar RS, et al. Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. J Ethnopharmacol. 2005;98(3):267-73.
Gupta, M., Mazumder, U. K., Kumar, R. S., Gomathi, P., Rajeshwar, Y., Kakoti, B. B., & Selven, V. T. (2005). Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. Journal of Ethnopharmacology, 98(3), 267-73.
Gupta M, et al. Anti-inflammatory, Analgesic and Antipyretic Effects of Methanol Extract From Bauhinia Racemosa Stem Bark in Animal Models. J Ethnopharmacol. 2005 Apr 26;98(3):267-73. PubMed PMID: 15814258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory, analgesic and antipyretic effects of methanol extract from Bauhinia racemosa stem bark in animal models. AU - Gupta,M, AU - Mazumder,U K, AU - Kumar,R Sambath, AU - Gomathi,P, AU - Rajeshwar,Y, AU - Kakoti,B B, AU - Selven,V Tamil, PY - 2004/03/05/received PY - 2004/12/30/revised PY - 2005/01/05/accepted PY - 2005/4/9/pubmed PY - 2005/7/21/medline PY - 2005/4/9/entrez SP - 267 EP - 73 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 98 IS - 3 N2 - In this study, the anti-inflammatory, analgesic, and antipyretic effects of 50, 100 and 200 mg/kg body weight of methanol extract obtained from Bauhinia racemosa stem bark, the so-called MEBR, were investigated. The effects of MEBR on the acute and chronic phases of inflammation were studied in carrageenan, dextran and mediators (histamine and serotonin)-induced paw oedema and cotton pellet-induced granuloma, respectively. Analgesic effect of MEBR was evaluated in acetic acid-induced writhing and hotplate tests. Antipyretic activity of MEBR was evaluated by yeast-induced hyperpyrexia in rats. The anti-oedema effect of MEBR was compared with 10 mg/kg of indomethacin orally. In acute phase of inflammation, a maximum inhibition of 44.9, 43.2, 44.8 and 45.9% (P<0.001) was noted at the dose of 200 mg/kg b.w. after 3h of treatment with MEBR in carrageenan, dextran, histamine and serotonin-induced paw oedema, respectively. Administration of MEBR (200 mg/kg b.w.) and indomethacin (10 mg/kg b.w.) significantly (P<0.05) decreased the formation of granuloma tissue induced by cotton pellet method at a rate of 50.4 and 56.2%, respectively. The extract also inhibited peritoneal leukocyte migration in mice. The MEBR also produced significant (P<0.01) analgesic activity in both models. Further, the MEBR potentiated the morphine- and aspirin-induced analgesic in mice. Treatment with MEBR showed a significant (P<0.01) dose-dependent reduction in pyrexia in rats. The results suggest that MEBR possess potent anti-inflammatory, analgesic and antipyretic activity. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15814258/Anti_inflammatory_analgesic_and_antipyretic_effects_of_methanol_extract_from_Bauhinia_racemosa_stem_bark_in_animal_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00062-0 DB - PRIME DP - Unbound Medicine ER -