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Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats.
J Ethnopharmacol. 2005 Apr 26; 98(3):287-94.JE

Abstract

The ulcer protective potential of an ethanol extract of Commiphora opobalsamum (L.) Engl. (Burseraceae) 'Balessan' was assessed against different acute gastric ulcer models in rats induced by necrotizing agents (80% ethanol, 0.2M NaOH and 25% NaCl), hypothermic restraint stress, pyloric ligation (Shay) and indomethacin. Balessan, 250 and 500 mg/kg administered orally (intraperitoneally in Shay rat model) showed a dose-dependent ulcer protective effects in all the above ulcer models. Besides, the extract offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl (NP-SH) concentration. Ethanol treatment also caused histopathological lesions of the stomach wall. Pretreatment with Balessan extract provided a complete protection of gastric mucosa through supporting both the offensive and defensive factors. Balessan extract was also showed a large margin of safety without any apparent adverse effects in rats.

Authors+Show Affiliations

Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15814261

Citation

Al-Howiriny, Tawfeq, et al. "Effect of Commiphora Opobalsamum (L.) Engl. (Balessan) On Experimental Gastric Ulcers and Secretion in Rats." Journal of Ethnopharmacology, vol. 98, no. 3, 2005, pp. 287-94.
Al-Howiriny T, Al-Sohaibani M, Al-Said M, et al. Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats. J Ethnopharmacol. 2005;98(3):287-94.
Al-Howiriny, T., Al-Sohaibani, M., Al-Said, M., Al-Yahya, M., El-Tahir, K., & Rafatullah, S. (2005). Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats. Journal of Ethnopharmacology, 98(3), 287-94.
Al-Howiriny T, et al. Effect of Commiphora Opobalsamum (L.) Engl. (Balessan) On Experimental Gastric Ulcers and Secretion in Rats. J Ethnopharmacol. 2005 Apr 26;98(3):287-94. PubMed PMID: 15814261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Commiphora opobalsamum (L.) Engl. (Balessan) on experimental gastric ulcers and secretion in rats. AU - Al-Howiriny,Tawfeq, AU - Al-Sohaibani,Mohammed, AU - Al-Said,Mansour, AU - Al-Yahya,Mohammed, AU - El-Tahir,Kamal, AU - Rafatullah,Syed, PY - 2004/11/18/received PY - 2005/01/14/revised PY - 2005/01/14/accepted PY - 2005/4/9/pubmed PY - 2005/7/21/medline PY - 2005/4/9/entrez SP - 287 EP - 94 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 98 IS - 3 N2 - The ulcer protective potential of an ethanol extract of Commiphora opobalsamum (L.) Engl. (Burseraceae) 'Balessan' was assessed against different acute gastric ulcer models in rats induced by necrotizing agents (80% ethanol, 0.2M NaOH and 25% NaCl), hypothermic restraint stress, pyloric ligation (Shay) and indomethacin. Balessan, 250 and 500 mg/kg administered orally (intraperitoneally in Shay rat model) showed a dose-dependent ulcer protective effects in all the above ulcer models. Besides, the extract offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl (NP-SH) concentration. Ethanol treatment also caused histopathological lesions of the stomach wall. Pretreatment with Balessan extract provided a complete protection of gastric mucosa through supporting both the offensive and defensive factors. Balessan extract was also showed a large margin of safety without any apparent adverse effects in rats. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15814261/Effect_of_Commiphora_opobalsamum__L___Engl___Balessan__on_experimental_gastric_ulcers_and_secretion_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00083-8 DB - PRIME DP - Unbound Medicine ER -