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High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal.
J Antimicrob Chemother. 2005 May; 55(5):788-91.JA

Abstract

OBJECTIVES

The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance. Chloroquine resistance is associated with the pfcrt gene K76T mutation. The aim of this study was to compare the prevalence rate of pfcrt T76 mutation in P. falciparum isolates from infected pregnant and non-pregnant individuals from Senegal.

METHODS

The study was conducted in the rural maternity hospital of Thiadiaye, Senegal, where malaria is seasonal. Sixty-nine P. falciparum isolates from infected women were collected at delivery. These women were part of a cohort study; they were followed from their first antenatal visit and advised to take chloroquine prophylaxis. For each woman, the earliest P. falciparum-infected blood sample was also used. A control group of 49 non-pregnant individuals with asymptomatic P. falciparum infection was enrolled.

RESULTS

During pregnancy, prevalence of T76 mutant parasites was higher than in the 49 non-pregnant controls (P<0.001). Among pregnant women, this rate was highest at delivery (P=0.06), and tended to be higher in women who had taken chloroquine prophylaxis, as assessed in urine samples (P=0.08).

CONCLUSIONS

Chloroquine prophylaxis is responsible for increased drug consumption and increased drug pressure that may lead to the selection of drug-resistant parasites. This is the first report showing that P. falciparum-infected pregnant women harbour pfcrt T76 mutant parasites more often than non-pregnant individuals, and that the prevalence of this mutation is higher at term than earlier during pregnancy.

Authors+Show Affiliations

Institut de Recherche pour le Développement, UR010, Mother and Child Health in the Tropics, Faculté de Pharmacie, 75006 Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15814601

Citation

Bertin, Gwladys, et al. "High Prevalence of Plasmodium Falciparum Pfcrt K76T Mutation in Pregnant Women Taking Chloroquine Prophylaxis in Senegal." The Journal of Antimicrobial Chemotherapy, vol. 55, no. 5, 2005, pp. 788-91.
Bertin G, Ndam NT, Jafari-Guemouri S, et al. High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal. J Antimicrob Chemother. 2005;55(5):788-91.
Bertin, G., Ndam, N. T., Jafari-Guemouri, S., Fievet, N., Renart, E., Sow, S., Le Hesran, J. Y., & Deloron, P. (2005). High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal. The Journal of Antimicrobial Chemotherapy, 55(5), 788-91.
Bertin G, et al. High Prevalence of Plasmodium Falciparum Pfcrt K76T Mutation in Pregnant Women Taking Chloroquine Prophylaxis in Senegal. J Antimicrob Chemother. 2005;55(5):788-91. PubMed PMID: 15814601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of Plasmodium falciparum pfcrt K76T mutation in pregnant women taking chloroquine prophylaxis in Senegal. AU - Bertin,Gwladys, AU - Ndam,Nicaise Tuikue, AU - Jafari-Guemouri,Sayeh, AU - Fievet,Nadine, AU - Renart,Emily, AU - Sow,Sokhna, AU - Le Hesran,Jean-Yves, AU - Deloron,Philippe, Y1 - 2005/04/06/ PY - 2005/4/9/pubmed PY - 2005/7/12/medline PY - 2005/4/9/entrez SP - 788 EP - 91 JF - The Journal of antimicrobial chemotherapy JO - J Antimicrob Chemother VL - 55 IS - 5 N2 - OBJECTIVES: The risk of malaria infection is increased during pregnancy, and many countries recommend chloroquine prophylaxis in pregnant women, despite Plasmodium falciparum chloroquine resistance. Chloroquine resistance is associated with the pfcrt gene K76T mutation. The aim of this study was to compare the prevalence rate of pfcrt T76 mutation in P. falciparum isolates from infected pregnant and non-pregnant individuals from Senegal. METHODS: The study was conducted in the rural maternity hospital of Thiadiaye, Senegal, where malaria is seasonal. Sixty-nine P. falciparum isolates from infected women were collected at delivery. These women were part of a cohort study; they were followed from their first antenatal visit and advised to take chloroquine prophylaxis. For each woman, the earliest P. falciparum-infected blood sample was also used. A control group of 49 non-pregnant individuals with asymptomatic P. falciparum infection was enrolled. RESULTS: During pregnancy, prevalence of T76 mutant parasites was higher than in the 49 non-pregnant controls (P<0.001). Among pregnant women, this rate was highest at delivery (P=0.06), and tended to be higher in women who had taken chloroquine prophylaxis, as assessed in urine samples (P=0.08). CONCLUSIONS: Chloroquine prophylaxis is responsible for increased drug consumption and increased drug pressure that may lead to the selection of drug-resistant parasites. This is the first report showing that P. falciparum-infected pregnant women harbour pfcrt T76 mutant parasites more often than non-pregnant individuals, and that the prevalence of this mutation is higher at term than earlier during pregnancy. SN - 0305-7453 UR - https://www.unboundmedicine.com/medline/citation/15814601/High_prevalence_of_Plasmodium_falciparum_pfcrt_K76T_mutation_in_pregnant_women_taking_chloroquine_prophylaxis_in_Senegal_ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dki097 DB - PRIME DP - Unbound Medicine ER -