Tags

Type your tag names separated by a space and hit enter

MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT).
Hepatogastroenterology 2005 Mar-Apr; 52(62):398-403H

Abstract

BACKGROUND/AIMS

To clarify the development of pancreatic cancer we performed immunohistochemical analysis of the presence of the major apomucin and cell-cycle regulatory proteins using the tissues of IPMT and ductal adenocarcinoma (DC) of the pancreas.

METHODOLOGY

Formalin-fixed and paraffin-embedded tissues of 24 IPMT and 21 DC cases were subjected to immunohistochemical staining for MUC1, MUC2, p16, p53 and DPC4. According to the WHO classification, there were 10 intraductal papillary-mucinous adenomas (IPMA); 3 borderline intraductal papillary-mucinous neoplasms (IPMB); 4 intraductal papillary-mucinous carcinomas (IPMC), non-invasive type (nIPMC); 4 IPMCs with invasive muci nous carcinoma (IPMC/muc); and 3 IPMCs with invasive tubular adenocarcinoma (IPMC/tub).

RESULTS

MUC1 expression was seen in 6 of 7 invasive IPMCs (86%) and in all DCs (100%). MUC2 was only seen in non-invasive IPMT and in a part of IPMC/muc. p53 nuclear staining was positive only in 3 of 7 invasive IPMCs (43%) and 9 of 21 DCs (43%). DPC4 nuclear expression was positive in almost all cases of non-invasive IPMT, but negative or reduced in 4 of 7 invasive IPMCs (57%), and 14 of 21 DCs (67%).

CONCLUSIONS

MUC1 overexpression is considered to be the most sensitive and specific marker of invasive carcinoma, followed by DPC4 and p53 with less sensitivity.

Authors+Show Affiliations

Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. michiou@med.yokohama-cu.ac.jp

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15816444

Citation

Ueda, Michio, et al. "MUC1 Overexpression Is the Most Reliable Marker of Invasive Carcinoma in Intraductal Papillary-mucinous Tumor (IPMT)." Hepato-gastroenterology, vol. 52, no. 62, 2005, pp. 398-403.
Ueda M, Miura Y, Kunihiro O, et al. MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT). Hepatogastroenterology. 2005;52(62):398-403.
Ueda, M., Miura, Y., Kunihiro, O., Ishikawa, T., Ichikawa, Y., Endo, I., ... Shimada, H. (2005). MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT). Hepato-gastroenterology, 52(62), pp. 398-403.
Ueda M, et al. MUC1 Overexpression Is the Most Reliable Marker of Invasive Carcinoma in Intraductal Papillary-mucinous Tumor (IPMT). Hepatogastroenterology. 2005;52(62):398-403. PubMed PMID: 15816444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MUC1 overexpression is the most reliable marker of invasive carcinoma in intraductal papillary-mucinous tumor (IPMT). AU - Ueda,Michio, AU - Miura,Yasuhiko, AU - Kunihiro,Osamu, AU - Ishikawa,Takashi, AU - Ichikawa,Yasushi, AU - Endo,Itaru, AU - Sekido,Hitoshi, AU - Togo,Shinji, AU - Shimada,Hiroshi, PY - 2005/4/9/pubmed PY - 2005/7/13/medline PY - 2005/4/9/entrez SP - 398 EP - 403 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 52 IS - 62 N2 - BACKGROUND/AIMS: To clarify the development of pancreatic cancer we performed immunohistochemical analysis of the presence of the major apomucin and cell-cycle regulatory proteins using the tissues of IPMT and ductal adenocarcinoma (DC) of the pancreas. METHODOLOGY: Formalin-fixed and paraffin-embedded tissues of 24 IPMT and 21 DC cases were subjected to immunohistochemical staining for MUC1, MUC2, p16, p53 and DPC4. According to the WHO classification, there were 10 intraductal papillary-mucinous adenomas (IPMA); 3 borderline intraductal papillary-mucinous neoplasms (IPMB); 4 intraductal papillary-mucinous carcinomas (IPMC), non-invasive type (nIPMC); 4 IPMCs with invasive muci nous carcinoma (IPMC/muc); and 3 IPMCs with invasive tubular adenocarcinoma (IPMC/tub). RESULTS: MUC1 expression was seen in 6 of 7 invasive IPMCs (86%) and in all DCs (100%). MUC2 was only seen in non-invasive IPMT and in a part of IPMC/muc. p53 nuclear staining was positive only in 3 of 7 invasive IPMCs (43%) and 9 of 21 DCs (43%). DPC4 nuclear expression was positive in almost all cases of non-invasive IPMT, but negative or reduced in 4 of 7 invasive IPMCs (57%), and 14 of 21 DCs (67%). CONCLUSIONS: MUC1 overexpression is considered to be the most sensitive and specific marker of invasive carcinoma, followed by DPC4 and p53 with less sensitivity. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/15816444/MUC1_overexpression_is_the_most_reliable_marker_of_invasive_carcinoma_in_intraductal_papillary_mucinous_tumor__IPMT__ L2 - https://medlineplus.gov/pancreaticcancer.html DB - PRIME DP - Unbound Medicine ER -