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Oxidative stress and endometriosis.

Abstract

BACKGROUND

Little is known about the aetiology of endometriosis; however, in the presence of oxidative stress, reactive oxygen species might increase growth and adhesion of endometrial cells in the peritoneal cavity, leading to endometriosis and infertility. Within a study investigating persistent organic compounds and endometriosis, the authors evaluated the association between oxidative stress and endometriosis.

METHODS

Women aged 18-40 years who were undergoing laparoscopy were contacted to participate in the study (n = 100); 84 were eligible and agreed to be interviewed; 78 provided blood specimens. Four markers of oxidative stress and antioxidant status were measured in serum for 61 women. Multiple imputation of missing data was used to generate values for the missing oxidative stress data.

RESULTS

Thirty-two women had visually confirmed endometriosis at laparoscopy while 52 did not, including 22 undergoing tubal ligation and 30 with idiopathic infertility. There was a weak association between thiobarbituric acid-reactive substances (nmol/ml) and endometriosis, after adjusting for age, body mass index, current smoking, hormone use in the past 12 months, gravidity, serum vitamin E, serum estradiol, and total serum lipids (beta = 1.18; 95% CI-0.04, 2.39).

CONCLUSIONS

These results suggest that oxidative stress might play a role in the development and progression of endometriosis, which should be evaluated in larger studies.

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  • Authors+Show Affiliations

    ,

    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA. jacksole@mail.nih.gov

    , , ,

    Source

    Human reproduction (Oxford, England) 20:7 2005 Jul pg 2014-20

    MeSH

    Adolescent
    Adult
    Antioxidants
    Aryldialkylphosphatase
    Biomarkers
    Dinoprost
    Endometriosis
    Female
    Humans
    Lipid Peroxidation
    Oxidative Stress
    Thiobarbituric Acid Reactive Substances

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15817589

    Citation

    Jackson, L W., et al. "Oxidative Stress and Endometriosis." Human Reproduction (Oxford, England), vol. 20, no. 7, 2005, pp. 2014-20.
    Jackson LW, Schisterman EF, Dey-Rao R, et al. Oxidative stress and endometriosis. Hum Reprod. 2005;20(7):2014-20.
    Jackson, L. W., Schisterman, E. F., Dey-Rao, R., Browne, R., & Armstrong, D. (2005). Oxidative stress and endometriosis. Human Reproduction (Oxford, England), 20(7), pp. 2014-20.
    Jackson LW, et al. Oxidative Stress and Endometriosis. Hum Reprod. 2005;20(7):2014-20. PubMed PMID: 15817589.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oxidative stress and endometriosis. AU - Jackson,L W, AU - Schisterman,E F, AU - Dey-Rao,R, AU - Browne,R, AU - Armstrong,D, Y1 - 2005/04/07/ PY - 2005/4/9/pubmed PY - 2005/10/18/medline PY - 2005/4/9/entrez SP - 2014 EP - 20 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 20 IS - 7 N2 - BACKGROUND: Little is known about the aetiology of endometriosis; however, in the presence of oxidative stress, reactive oxygen species might increase growth and adhesion of endometrial cells in the peritoneal cavity, leading to endometriosis and infertility. Within a study investigating persistent organic compounds and endometriosis, the authors evaluated the association between oxidative stress and endometriosis. METHODS: Women aged 18-40 years who were undergoing laparoscopy were contacted to participate in the study (n = 100); 84 were eligible and agreed to be interviewed; 78 provided blood specimens. Four markers of oxidative stress and antioxidant status were measured in serum for 61 women. Multiple imputation of missing data was used to generate values for the missing oxidative stress data. RESULTS: Thirty-two women had visually confirmed endometriosis at laparoscopy while 52 did not, including 22 undergoing tubal ligation and 30 with idiopathic infertility. There was a weak association between thiobarbituric acid-reactive substances (nmol/ml) and endometriosis, after adjusting for age, body mass index, current smoking, hormone use in the past 12 months, gravidity, serum vitamin E, serum estradiol, and total serum lipids (beta = 1.18; 95% CI-0.04, 2.39). CONCLUSIONS: These results suggest that oxidative stress might play a role in the development and progression of endometriosis, which should be evaluated in larger studies. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15817589/Oxidative_stress_and_endometriosis_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dei001 DB - PRIME DP - Unbound Medicine ER -