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Dietary fat intake and early age-related lens opacities.

Abstract

BACKGROUND

Dietary fat may affect lens cell membrane composition and function, which are related to age-related cataract.

OBJECTIVE

The objective of the study was to examine the association between long-term dietary fat intake and the prevalence of age-related nuclear, cortical, and posterior subcapsular lens opacities.

DESIGN

Women (n = 440) aged 53-73 y from the Boston area without previously diagnosed cancer, diabetes, or cataract were selected from the Nurses' Health Study cohort. Intakes of total fat and selected fatty acids were calculated as the average of intake data from 5 food-frequency questionnaires collected between 1980 and the study eye examination (1993-1995). Nuclear opacity was defined as grade >/=2.5, cortical opacity as grade >/=1.0, and posterior subcapsular opacity as grade >/=0.5 according to the Lens Opacities Classification System III.

RESULTS

There were significant positive associations between linoleic and linolenic acid intakes and the prevalence of nuclear opacity. The odds ratios for nuclear opacity in women with intakes in the highest quartile and women with intakes in the lowest quartile were 2.2 (95% CI: 1.1, 4.6; P for trend = 0.02) for linoleic acid and 2.2 (95% CI: 1.1, 4.5; P for trend = 0.05) for linolenic acid. There were no significant associations between intakes of any type of fat and either cortical or posterior subscapular opacity.

CONCLUSIONS

High intake of the 18-carbon polyunsaturated fatty acids linoleic acid and linolenic acid may increase the risk of age-related nuclear opacity. Further study is needed to clarify the relation between dietary fat and cataract risk.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Program and the Center for Ophthalmic Research, Department of Ophthalmology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

    , , , , ,

    Source

    MeSH

    Aged
    Boston
    Cataract
    Cross-Sectional Studies
    Diet Surveys
    Dietary Fats
    Fatty Acids, Unsaturated
    Female
    Humans
    Longitudinal Studies
    Middle Aged
    Prevalence
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15817851

    Citation

    Lu, Minyi, et al. "Dietary Fat Intake and Early Age-related Lens Opacities." The American Journal of Clinical Nutrition, vol. 81, no. 4, 2005, pp. 773-9.
    Lu M, Taylor A, Chylack LT, et al. Dietary fat intake and early age-related lens opacities. Am J Clin Nutr. 2005;81(4):773-9.
    Lu, M., Taylor, A., Chylack, L. T., Rogers, G., Hankinson, S. E., Willett, W. C., & Jacques, P. F. (2005). Dietary fat intake and early age-related lens opacities. The American Journal of Clinical Nutrition, 81(4), pp. 773-9.
    Lu M, et al. Dietary Fat Intake and Early Age-related Lens Opacities. Am J Clin Nutr. 2005;81(4):773-9. PubMed PMID: 15817851.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fat intake and early age-related lens opacities. AU - Lu,Minyi, AU - Taylor,Allen, AU - Chylack,Leo T,Jr AU - Rogers,Gail, AU - Hankinson,Susan E, AU - Willett,Walter C, AU - Jacques,Paul F, PY - 2005/4/9/pubmed PY - 2005/5/4/medline PY - 2005/4/9/entrez SP - 773 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 81 IS - 4 N2 - BACKGROUND: Dietary fat may affect lens cell membrane composition and function, which are related to age-related cataract. OBJECTIVE: The objective of the study was to examine the association between long-term dietary fat intake and the prevalence of age-related nuclear, cortical, and posterior subcapsular lens opacities. DESIGN: Women (n = 440) aged 53-73 y from the Boston area without previously diagnosed cancer, diabetes, or cataract were selected from the Nurses' Health Study cohort. Intakes of total fat and selected fatty acids were calculated as the average of intake data from 5 food-frequency questionnaires collected between 1980 and the study eye examination (1993-1995). Nuclear opacity was defined as grade >/=2.5, cortical opacity as grade >/=1.0, and posterior subcapsular opacity as grade >/=0.5 according to the Lens Opacities Classification System III. RESULTS: There were significant positive associations between linoleic and linolenic acid intakes and the prevalence of nuclear opacity. The odds ratios for nuclear opacity in women with intakes in the highest quartile and women with intakes in the lowest quartile were 2.2 (95% CI: 1.1, 4.6; P for trend = 0.02) for linoleic acid and 2.2 (95% CI: 1.1, 4.5; P for trend = 0.05) for linolenic acid. There were no significant associations between intakes of any type of fat and either cortical or posterior subscapular opacity. CONCLUSIONS: High intake of the 18-carbon polyunsaturated fatty acids linoleic acid and linolenic acid may increase the risk of age-related nuclear opacity. Further study is needed to clarify the relation between dietary fat and cataract risk. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15817851/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/81.4.773 DB - PRIME DP - Unbound Medicine ER -