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Effectiveness of selenium supplements in a low-selenium area of China.
Am J Clin Nutr 2005; 81(4):829-34AJ

Abstract

BACKGROUND

Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins. Although there is no evidence of selenium deficiency in the United States, people in many other areas of the world are selenium deficient, with the consequence that they are unable to express their selenoproteins fully.

OBJECTIVE

We carried out a supplementation trial in a selenium-deficient population in China to assess the requirement for selenium as selenite and as selenomethionine.

DESIGN

One hundred twenty subjects with an average selenium intake of 10 mug/d were randomly assigned and administered tablets containing no selenium or amounts as high as 66 mug Se/d for 20 wk. Plasma was sampled before supplementation and at 4-wk intervals during supplementation and was assayed for the 2 plasma selenoproteins, glutathione peroxidase and selenoprotein P.

RESULTS

Full expression of glutathione peroxidase was achieved with 37 mug Se/d as selenomethionine and with 66 mug/d as selenite. Full expression of selenoprotein P was not achieved at the highest doses of either form.

CONCLUSIONS

Full expression of selenoprotein P requires a greater selenium intake than does full expression of plasma glutathione peroxidase. This suggests that selenoprotein P is a better indicator of selenium nutritional status than is glutathione peroxidase and that the recommended dietary allowance of selenium, which was set with the use of glutathione peroxidase as the index of selenium status, should be revised. Selenium as selenomethionine had nearly twice the bioavailability of selenium as selenite.

Authors+Show Affiliations

Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15817859

Citation

Xia, Yiming, et al. "Effectiveness of Selenium Supplements in a Low-selenium Area of China." The American Journal of Clinical Nutrition, vol. 81, no. 4, 2005, pp. 829-34.
Xia Y, Hill KE, Byrne DW, et al. Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr. 2005;81(4):829-34.
Xia, Y., Hill, K. E., Byrne, D. W., Xu, J., & Burk, R. F. (2005). Effectiveness of selenium supplements in a low-selenium area of China. The American Journal of Clinical Nutrition, 81(4), pp. 829-34.
Xia Y, et al. Effectiveness of Selenium Supplements in a Low-selenium Area of China. Am J Clin Nutr. 2005;81(4):829-34. PubMed PMID: 15817859.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of selenium supplements in a low-selenium area of China. AU - Xia,Yiming, AU - Hill,Kristina E, AU - Byrne,Daniel W, AU - Xu,Jiayuan, AU - Burk,Raymond F, PY - 2005/4/9/pubmed PY - 2005/5/4/medline PY - 2005/4/9/entrez SP - 829 EP - 34 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 81 IS - 4 N2 - BACKGROUND: Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins. Although there is no evidence of selenium deficiency in the United States, people in many other areas of the world are selenium deficient, with the consequence that they are unable to express their selenoproteins fully. OBJECTIVE: We carried out a supplementation trial in a selenium-deficient population in China to assess the requirement for selenium as selenite and as selenomethionine. DESIGN: One hundred twenty subjects with an average selenium intake of 10 mug/d were randomly assigned and administered tablets containing no selenium or amounts as high as 66 mug Se/d for 20 wk. Plasma was sampled before supplementation and at 4-wk intervals during supplementation and was assayed for the 2 plasma selenoproteins, glutathione peroxidase and selenoprotein P. RESULTS: Full expression of glutathione peroxidase was achieved with 37 mug Se/d as selenomethionine and with 66 mug/d as selenite. Full expression of selenoprotein P was not achieved at the highest doses of either form. CONCLUSIONS: Full expression of selenoprotein P requires a greater selenium intake than does full expression of plasma glutathione peroxidase. This suggests that selenoprotein P is a better indicator of selenium nutritional status than is glutathione peroxidase and that the recommended dietary allowance of selenium, which was set with the use of glutathione peroxidase as the index of selenium status, should be revised. Selenium as selenomethionine had nearly twice the bioavailability of selenium as selenite. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15817859/Effectiveness_of_selenium_supplements_in_a_low_selenium_area_of_China_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/81.4.829 DB - PRIME DP - Unbound Medicine ER -