Tags

Type your tag names separated by a space and hit enter

Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions.
Aquat Toxicol. 2005 Apr 30; 72(3):261-71.AT

Abstract

The effects of microcystins from cyanobacterial cells on various oxidative stress biomarkers in liver, kidney and gill tissues in freshwater tilapia fish (Oreochromis sp.) were investigated under laboratory conditions. Microcystins are a family of cyclic peptide toxins produced by species of freshwater cyanobacteria (blue-green algae). Fish were exposed to the cyanobacterial cells in two ways: mixed with a commercial fish food or crushed into a commercial fish food so that the toxins were released. Two different exposure times were studied: 14 and 21 days. The oxidative status of fish was evaluated by analyzing the level of lipid peroxidation (LPO), as well as the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). The findings of the present investigation show that microcystins induce oxidative stress in a time-dependent manner and that the type of administration of the cyanobacterial cells influences the extent of these effects. Thus, the crushed cyanobacterial cells (released toxins) induced the antioxidant defences studied and increased the LPO level to a greater extent than the non-crushed cells. The liver was the most affected organ followed by kidney and gills. These results together with reports that fish can accumulate microcystins mean that cyanobacterial blooms are an important health, environmental and economic problem.

Authors+Show Affiliations

Area of Toxicology, Faculty of Pharmacy, University of Seville, Profesor García González no. 2, 41012 Seville, Spain. angelesjos@us.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15820106

Citation

Jos, Angeles, et al. "Toxic Cyanobacterial Cells Containing Microcystins Induce Oxidative Stress in Exposed Tilapia Fish (Oreochromis Sp.) Under Laboratory Conditions." Aquatic Toxicology (Amsterdam, Netherlands), vol. 72, no. 3, 2005, pp. 261-71.
Jos A, Pichardo S, Prieto AI, et al. Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. Aquat Toxicol. 2005;72(3):261-71.
Jos, A., Pichardo, S., Prieto, A. I., Repetto, G., Vázquez, C. M., Moreno, I., & Cameán, A. M. (2005). Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. Aquatic Toxicology (Amsterdam, Netherlands), 72(3), 261-71.
Jos A, et al. Toxic Cyanobacterial Cells Containing Microcystins Induce Oxidative Stress in Exposed Tilapia Fish (Oreochromis Sp.) Under Laboratory Conditions. Aquat Toxicol. 2005 Apr 30;72(3):261-71. PubMed PMID: 15820106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish (Oreochromis sp.) under laboratory conditions. AU - Jos,Angeles, AU - Pichardo,Silvia, AU - Prieto,Ana I, AU - Repetto,Guillermo, AU - Vázquez,Carmen M, AU - Moreno,Isabel, AU - Cameán,Ana M, PY - 2004/10/04/received PY - 2005/01/13/revised PY - 2005/01/18/accepted PY - 2005/4/12/pubmed PY - 2005/6/10/medline PY - 2005/4/12/entrez SP - 261 EP - 71 JF - Aquatic toxicology (Amsterdam, Netherlands) JO - Aquat Toxicol VL - 72 IS - 3 N2 - The effects of microcystins from cyanobacterial cells on various oxidative stress biomarkers in liver, kidney and gill tissues in freshwater tilapia fish (Oreochromis sp.) were investigated under laboratory conditions. Microcystins are a family of cyclic peptide toxins produced by species of freshwater cyanobacteria (blue-green algae). Fish were exposed to the cyanobacterial cells in two ways: mixed with a commercial fish food or crushed into a commercial fish food so that the toxins were released. Two different exposure times were studied: 14 and 21 days. The oxidative status of fish was evaluated by analyzing the level of lipid peroxidation (LPO), as well as the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). The findings of the present investigation show that microcystins induce oxidative stress in a time-dependent manner and that the type of administration of the cyanobacterial cells influences the extent of these effects. Thus, the crushed cyanobacterial cells (released toxins) induced the antioxidant defences studied and increased the LPO level to a greater extent than the non-crushed cells. The liver was the most affected organ followed by kidney and gills. These results together with reports that fish can accumulate microcystins mean that cyanobacterial blooms are an important health, environmental and economic problem. SN - 0166-445X UR - https://www.unboundmedicine.com/medline/citation/15820106/Toxic_cyanobacterial_cells_containing_microcystins_induce_oxidative_stress_in_exposed_tilapia_fish__Oreochromis_sp___under_laboratory_conditions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-445X(05)00015-9 DB - PRIME DP - Unbound Medicine ER -