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Prospective cohort study of hostility and the risk of cardiovascular disease mortality.
Int J Cardiol. 2005 Apr 08; 100(1):155-61.IJ

Abstract

BACKGROUND

Recent literature reviews have questioned hostility as a risk factor for heart disease. However, controversy persists due to the rarity of large-scale prospective cohort studies of initially healthy populations.

METHODS

We prospectively investigated the association between hostility and cardiovascular (and all-cause) mortality among 20,550 men and women, 41-80 years of age, participating in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk), United Kingdom study. Participants were recruited by post from general practice age-sex registers and subsequently attended health checks that included the assessment of coronary disease risk factors. Hostility assessment was completed by postal questionnaire.

RESULTS

During mean follow-up of 6 years, 1284 deaths were recorded including 481 from cardiovascular disease (CVD). Hostility was not associated with CVD mortality, after adjustment for age and prevalent disease, in either men (rate ratio for a 1 SD decrease in hostility score, representing increased hostility, 1.09; 95% confidence interval 0.98-1.22) or in women (rate ratio 1.00; 95% confidence interval 0.86-1.26). Subgroup analysis suggested hostility may be associated with CVD mortality (independent of age, prevalent disease and cigarette smoking) for participants reporting very high hostility and for those aged less than 60 years.

CONCLUSIONS

Hostility was not associated with an increased risk of cardiovascular mortality in this population study of older adults.

Authors+Show Affiliations

Strangeways Research Laboratory and Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK. paul.surtees@srl.cam.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15820299

Citation

Surtees, Paul G., et al. "Prospective Cohort Study of Hostility and the Risk of Cardiovascular Disease Mortality." International Journal of Cardiology, vol. 100, no. 1, 2005, pp. 155-61.
Surtees PG, Wainwright NW, Luben R, et al. Prospective cohort study of hostility and the risk of cardiovascular disease mortality. Int J Cardiol. 2005;100(1):155-61.
Surtees, P. G., Wainwright, N. W., Luben, R., Day, N. E., & Khaw, K. T. (2005). Prospective cohort study of hostility and the risk of cardiovascular disease mortality. International Journal of Cardiology, 100(1), 155-61.
Surtees PG, et al. Prospective Cohort Study of Hostility and the Risk of Cardiovascular Disease Mortality. Int J Cardiol. 2005 Apr 8;100(1):155-61. PubMed PMID: 15820299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective cohort study of hostility and the risk of cardiovascular disease mortality. AU - Surtees,Paul G, AU - Wainwright,Nicholas W J, AU - Luben,Robert, AU - Day,Nicholas E, AU - Khaw,Kay-Tee, PY - 2004/09/17/received PY - 2005/01/05/revised PY - 2005/01/06/accepted PY - 2005/4/12/pubmed PY - 2005/9/1/medline PY - 2005/4/12/entrez SP - 155 EP - 61 JF - International journal of cardiology JO - Int J Cardiol VL - 100 IS - 1 N2 - BACKGROUND: Recent literature reviews have questioned hostility as a risk factor for heart disease. However, controversy persists due to the rarity of large-scale prospective cohort studies of initially healthy populations. METHODS: We prospectively investigated the association between hostility and cardiovascular (and all-cause) mortality among 20,550 men and women, 41-80 years of age, participating in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk), United Kingdom study. Participants were recruited by post from general practice age-sex registers and subsequently attended health checks that included the assessment of coronary disease risk factors. Hostility assessment was completed by postal questionnaire. RESULTS: During mean follow-up of 6 years, 1284 deaths were recorded including 481 from cardiovascular disease (CVD). Hostility was not associated with CVD mortality, after adjustment for age and prevalent disease, in either men (rate ratio for a 1 SD decrease in hostility score, representing increased hostility, 1.09; 95% confidence interval 0.98-1.22) or in women (rate ratio 1.00; 95% confidence interval 0.86-1.26). Subgroup analysis suggested hostility may be associated with CVD mortality (independent of age, prevalent disease and cigarette smoking) for participants reporting very high hostility and for those aged less than 60 years. CONCLUSIONS: Hostility was not associated with an increased risk of cardiovascular mortality in this population study of older adults. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15820299/Prospective_cohort_study_of_hostility_and_the_risk_of_cardiovascular_disease_mortality_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00278-0 DB - PRIME DP - Unbound Medicine ER -