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Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia.
Clin Chim Acta 2005; 355(1-2):83-9CC

Abstract

BACKGROUND

This study investigated the associations of soluble transferrin receptor (sTfR), log ferritin, the ratio of sTfR to log ferritin (sTfR-F index), and the log of the ratio of sTfR to ferritin [log(sTfR/F)] vs. reticulocyte production during iron deficiency.

METHODS

Fluorescent intensity of reticulocytes, immature reticulocyte fraction (IRF), reticulocyte maturity index (RMI), sTfR, and serum ferritin were measured in 149 adolescents.

RESULTS

There were no significant differences in reticulocyte parameters between the iron deficiency anemia (IDA) subjects with sTfR> or =4.9 mg/l and those with sTfR<4.9 mg/l. However, IDA subjects with log ferritin <0.73 microg/l exhibited significantly higher mean values for IRF and RMI, compared to those with log ferritin > or =0.73 microg/l (2.75+/-1.36% vs. 1.45+/-1.01%, p<0.05; 2.76+/-1.31% vs. 1.46+/-1.09%, p<0.05). In the non-IDA group, reticulocytes averaged 0.97+/-0.31% in subjects with sTfR> or =2.1 mg/l, which were significantly above the values in those with sTfR<2.1 mg/l (0.72+/-0.16%, p=0.005), but no significant differences were observed in reticulocyte parameters between the subjects with log ferritin > or =1.35 microg/l and those with log ferritin <1.35 microg/l. Correlation coefficients of log ferritin vs. RMI (r=-0.41) were higher than those of sTfR, sTfR-F index, and log(sTfR/F) vs. RMI (r=0.24, r=0.30, and r=0.28, respectively) in IDA subjects.

CONCLUSION

Reticulocytopoiesis is more closely associated with log ferritin value than with sTfR concentrations in IDA patients, although sTfR significantly reflects erythropoietic activity in non-IDA subjects.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Choi JW
    Department of Laboratory Medicine, Inha University Hospital, 7-206, 3-ga, Shinheung-dong, Jung-gu, Inchon 400-711, South Korea. jwchoi@inha.ac.kr
    Son BK
    No affiliation info available

    MeSH

    AdolescentAnemia, Iron-DeficiencyErythropoiesisFemaleFerritinsHumansMaleReceptors, Transferrin

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15820481

    Citation

    Choi, Jong Weon, and Byong Kwan Son. "Soluble Transferrin Receptor Concentration Is Not Superior to Log Ferritin for Evaluating Erythropoiesis in Adolescents With Iron Deficiency Anemia." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 355, no. 1-2, 2005, pp. 83-9.
    Choi JW, Son BK. Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia. Clin Chim Acta. 2005;355(1-2):83-9.
    Choi, J. W., & Son, B. K. (2005). Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia. Clinica Chimica Acta; International Journal of Clinical Chemistry, 355(1-2), pp. 83-9.
    Choi JW, Son BK. Soluble Transferrin Receptor Concentration Is Not Superior to Log Ferritin for Evaluating Erythropoiesis in Adolescents With Iron Deficiency Anemia. Clin Chim Acta. 2005;355(1-2):83-9. PubMed PMID: 15820481.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Soluble transferrin receptor concentration is not superior to log ferritin for evaluating erythropoiesis in adolescents with iron deficiency anemia. AU - Choi,Jong Weon, AU - Son,Byong Kwan, PY - 2004/10/06/received PY - 2004/12/14/revised PY - 2004/12/15/accepted PY - 2005/4/12/pubmed PY - 2005/9/1/medline PY - 2005/4/12/entrez SP - 83 EP - 9 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 355 IS - 1-2 N2 - BACKGROUND: This study investigated the associations of soluble transferrin receptor (sTfR), log ferritin, the ratio of sTfR to log ferritin (sTfR-F index), and the log of the ratio of sTfR to ferritin [log(sTfR/F)] vs. reticulocyte production during iron deficiency. METHODS: Fluorescent intensity of reticulocytes, immature reticulocyte fraction (IRF), reticulocyte maturity index (RMI), sTfR, and serum ferritin were measured in 149 adolescents. RESULTS: There were no significant differences in reticulocyte parameters between the iron deficiency anemia (IDA) subjects with sTfR> or =4.9 mg/l and those with sTfR<4.9 mg/l. However, IDA subjects with log ferritin <0.73 microg/l exhibited significantly higher mean values for IRF and RMI, compared to those with log ferritin > or =0.73 microg/l (2.75+/-1.36% vs. 1.45+/-1.01%, p<0.05; 2.76+/-1.31% vs. 1.46+/-1.09%, p<0.05). In the non-IDA group, reticulocytes averaged 0.97+/-0.31% in subjects with sTfR> or =2.1 mg/l, which were significantly above the values in those with sTfR<2.1 mg/l (0.72+/-0.16%, p=0.005), but no significant differences were observed in reticulocyte parameters between the subjects with log ferritin > or =1.35 microg/l and those with log ferritin <1.35 microg/l. Correlation coefficients of log ferritin vs. RMI (r=-0.41) were higher than those of sTfR, sTfR-F index, and log(sTfR/F) vs. RMI (r=0.24, r=0.30, and r=0.28, respectively) in IDA subjects. CONCLUSION: Reticulocytopoiesis is more closely associated with log ferritin value than with sTfR concentrations in IDA patients, although sTfR significantly reflects erythropoietic activity in non-IDA subjects. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15820481/Soluble_transferrin_receptor_concentration_is_not_superior_to_log_ferritin_for_evaluating_erythropoiesis_in_adolescents_with_iron_deficiency_anemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(05)00010-0 DB - PRIME DP - Unbound Medicine ER -