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Pain TRPs.
Neuron. 2005 Apr 07; 46(1):9-12.N

Abstract

Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems, an interface between the environment and the nervous system. Several TRPs transduce thermal, chemical, and mechanical stimuli into inward currents, an essential first step for eliciting thermal and pain sensations. Precise regulation of the expression, localization, and function of the TRP channels is crucial for their sensory role in nociceptor terminals, particularly after inflammation, when they contribute to pain hypersensitivity by undergoing changes in translation and trafficking as well as diverse posttranslational modifications.

Authors+Show Affiliations

Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15820689

Citation

Wang, Haibin, and Clifford J. Woolf. "Pain TRPs." Neuron, vol. 46, no. 1, 2005, pp. 9-12.
Wang H, Woolf CJ. Pain TRPs. Neuron. 2005;46(1):9-12.
Wang, H., & Woolf, C. J. (2005). Pain TRPs. Neuron, 46(1), 9-12.
Wang H, Woolf CJ. Pain TRPs. Neuron. 2005 Apr 7;46(1):9-12. PubMed PMID: 15820689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pain TRPs. AU - Wang,Haibin, AU - Woolf,Clifford J, PY - 2005/4/12/pubmed PY - 2005/5/21/medline PY - 2005/4/12/entrez SP - 9 EP - 12 JF - Neuron JO - Neuron VL - 46 IS - 1 N2 - Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems, an interface between the environment and the nervous system. Several TRPs transduce thermal, chemical, and mechanical stimuli into inward currents, an essential first step for eliciting thermal and pain sensations. Precise regulation of the expression, localization, and function of the TRP channels is crucial for their sensory role in nociceptor terminals, particularly after inflammation, when they contribute to pain hypersensitivity by undergoing changes in translation and trafficking as well as diverse posttranslational modifications. SN - 0896-6273 UR - https://www.unboundmedicine.com/medline/citation/15820689/Pain_TRPs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-6273(05)00206-0 DB - PRIME DP - Unbound Medicine ER -