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Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa.
Biol Psychiatry 2005; 57(8):926-31BP

Abstract

BACKGROUND

Gut-derived peptides, such as peptide YY (PYY) and ghrelin that regulate the initiation and termination of meals, could play a role in the altered eating behavior of patients with bulimia nervosa (BN). Therefore, we aimed to assess plasma PYY and ghrelin responses to a test meal in symptomatic bulimics.

METHODS

Ten healthy women and nine women with BN underwent blood sample collections before and after the ingestion of a test meal of 1300 Kcal (with 15% carbohydrates, 10% proteins, and 75% fat) at 12:00 noon. Plasma total PYY, ghrelin, insulin, and glucose were assayed.

RESULTS

As compared with healthy women, bulimics exhibited a significantly blunted increase of circulating PYY (p < .007) and a significantly reduced suppression of plasma ghrelin (p < .0004) after the test meal. No significant differences emerged in food-induced plasma insulin and glucose changes between the two groups. Plasma ghrelin suppression after the meal was significantly correlated with plasma PYY increase.

CONCLUSIONS

We replicated our previous findings of an altered ghrelin response to food ingestion in people with BN and showed for the first time a blunted PYY increase after food consumption in these patients. These findings support the occurrence in BN of a profound dysregulation of some peripheral regulatory mechanisms involved in the short-term regulation of feeding behavior that might be involved in the pathophysiology of their binge eating behavior.

Authors+Show Affiliations

Department of Psychiatry, University of Naples SUN, Naples, Italy. monteri@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15820714

Citation

Monteleone, Palmiero, et al. "Investigation of Peptide YY and Ghrelin Responses to a Test Meal in Bulimia Nervosa." Biological Psychiatry, vol. 57, no. 8, 2005, pp. 926-31.
Monteleone P, Martiadis V, Rigamonti AE, et al. Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa. Biol Psychiatry. 2005;57(8):926-31.
Monteleone, P., Martiadis, V., Rigamonti, A. E., Fabrazzo, M., Giordani, C., Muller, E. E., & Maj, M. (2005). Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa. Biological Psychiatry, 57(8), pp. 926-31.
Monteleone P, et al. Investigation of Peptide YY and Ghrelin Responses to a Test Meal in Bulimia Nervosa. Biol Psychiatry. 2005 Apr 15;57(8):926-31. PubMed PMID: 15820714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of peptide YY and ghrelin responses to a test meal in bulimia nervosa. AU - Monteleone,Palmiero, AU - Martiadis,Vassilis, AU - Rigamonti,Antonello E, AU - Fabrazzo,Michele, AU - Giordani,Claudio, AU - Muller,Eugenio E, AU - Maj,Mario, PY - 2004/09/22/received PY - 2004/12/13/revised PY - 2005/01/03/accepted PY - 2005/4/12/pubmed PY - 2005/5/17/medline PY - 2005/4/12/entrez SP - 926 EP - 31 JF - Biological psychiatry JO - Biol. Psychiatry VL - 57 IS - 8 N2 - BACKGROUND: Gut-derived peptides, such as peptide YY (PYY) and ghrelin that regulate the initiation and termination of meals, could play a role in the altered eating behavior of patients with bulimia nervosa (BN). Therefore, we aimed to assess plasma PYY and ghrelin responses to a test meal in symptomatic bulimics. METHODS: Ten healthy women and nine women with BN underwent blood sample collections before and after the ingestion of a test meal of 1300 Kcal (with 15% carbohydrates, 10% proteins, and 75% fat) at 12:00 noon. Plasma total PYY, ghrelin, insulin, and glucose were assayed. RESULTS: As compared with healthy women, bulimics exhibited a significantly blunted increase of circulating PYY (p < .007) and a significantly reduced suppression of plasma ghrelin (p < .0004) after the test meal. No significant differences emerged in food-induced plasma insulin and glucose changes between the two groups. Plasma ghrelin suppression after the meal was significantly correlated with plasma PYY increase. CONCLUSIONS: We replicated our previous findings of an altered ghrelin response to food ingestion in people with BN and showed for the first time a blunted PYY increase after food consumption in these patients. These findings support the occurrence in BN of a profound dysregulation of some peripheral regulatory mechanisms involved in the short-term regulation of feeding behavior that might be involved in the pathophysiology of their binge eating behavior. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/15820714/Investigation_of_peptide_YY_and_ghrelin_responses_to_a_test_meal_in_bulimia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(05)00007-7 DB - PRIME DP - Unbound Medicine ER -