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Role of surgery in the treatment of motor complications.
Mov Disord. 2005; 20 Suppl 11:S45-56.MD

Abstract

When medications no longer provide patients with Parkinson's disease a reasonable quality of life due to the presence of levodopa-associated motor fluctuations and dyskinesias, surgical treatment is often pursued. Numerous studies have examined the antiparkinsonian efficacy of procedures currently available, but surprisingly few studies have evaluated their effect on motor response complications in a systematic, controlled manner, using appropriate instruments. Nonetheless, the combined evidence from uncontrolled case series and more recent randomized controlled trials reviewed here indicates that unilateral pallidotomy, bilateral pallidal deep brain stimulation, and bilateral subthalamic deep brain stimulation all substantially alleviate levodopa-induced dyskinesias and, to a lesser extent, motor fluctuations. Incorporation of standardized, validated instruments for the quantification of motor response complications in future surgical study protocols will not only allow more accurate comparison of different interventions but also will help physicians select the most appropriate procedure for their patients.

Authors+Show Affiliations

Department of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison Street, Chicago, IL 60612, USA. lverhage@rush.orgNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15822076

Citation

Metman, Leo Verhagen, and Shaun T. O'Leary. "Role of Surgery in the Treatment of Motor Complications." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 20 Suppl 11, 2005, pp. S45-56.
Metman LV, O'Leary ST. Role of surgery in the treatment of motor complications. Mov Disord. 2005;20 Suppl 11:S45-56.
Metman, L. V., & O'Leary, S. T. (2005). Role of surgery in the treatment of motor complications. Movement Disorders : Official Journal of the Movement Disorder Society, 20 Suppl 11, S45-56.
Metman LV, O'Leary ST. Role of Surgery in the Treatment of Motor Complications. Mov Disord. 2005;20 Suppl 11:S45-56. PubMed PMID: 15822076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of surgery in the treatment of motor complications. AU - Metman,Leo Verhagen, AU - O'Leary,Shaun T, PY - 2005/4/12/pubmed PY - 2005/8/27/medline PY - 2005/4/12/entrez SP - S45 EP - 56 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 20 Suppl 11 N2 - When medications no longer provide patients with Parkinson's disease a reasonable quality of life due to the presence of levodopa-associated motor fluctuations and dyskinesias, surgical treatment is often pursued. Numerous studies have examined the antiparkinsonian efficacy of procedures currently available, but surprisingly few studies have evaluated their effect on motor response complications in a systematic, controlled manner, using appropriate instruments. Nonetheless, the combined evidence from uncontrolled case series and more recent randomized controlled trials reviewed here indicates that unilateral pallidotomy, bilateral pallidal deep brain stimulation, and bilateral subthalamic deep brain stimulation all substantially alleviate levodopa-induced dyskinesias and, to a lesser extent, motor fluctuations. Incorporation of standardized, validated instruments for the quantification of motor response complications in future surgical study protocols will not only allow more accurate comparison of different interventions but also will help physicians select the most appropriate procedure for their patients. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/15822076/Role_of_surgery_in_the_treatment_of_motor_complications_ L2 - https://doi.org/10.1002/mds.20480 DB - PRIME DP - Unbound Medicine ER -