Tags

Type your tag names separated by a space and hit enter

Other pharmacological treatments for motor complications and dyskinesias.
Mov Disord. 2005; 20 Suppl 11:S38-44.MD

Abstract

Controlling motor complications becomes increasingly difficult with disease progression. The "wearing-off" phenomenon is the most-common motor fluctuation. Wearing-off can be treated by dietary manipulation, shortening the dosing interval, substituting sustained-release levodopa, adding amantadine, or monoamine oxidase type B inhibitors, and other options, including catechol-O-methyltransferase inhibitors and the approved dopamine agonists addressed in another chapter. The rotigotine constant-delivery system is being developed to treat wearing-off symptoms. Istradefylline (KW-6002), an adenosine A(2A) receptor antagonist, has been studied for wearing-off and the results will be discussed. The on-off fluctuations can be treated with liquid levodopa and the rescue therapy of injectable apomorphine. Patients may also suffer from dyskinesias. Dyskinesias can be treated with small doses of liquefied levodopa-carbidopa, amantadine, and clozapine, an atypical neuroleptic.

Authors+Show Affiliations

Division of Movement Disorders, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA. cw345@columbia.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15822104

Citation

Waters, Cheryl. "Other Pharmacological Treatments for Motor Complications and Dyskinesias." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 20 Suppl 11, 2005, pp. S38-44.
Waters C. Other pharmacological treatments for motor complications and dyskinesias. Mov Disord. 2005;20 Suppl 11:S38-44.
Waters, C. (2005). Other pharmacological treatments for motor complications and dyskinesias. Movement Disorders : Official Journal of the Movement Disorder Society, 20 Suppl 11, S38-44.
Waters C. Other Pharmacological Treatments for Motor Complications and Dyskinesias. Mov Disord. 2005;20 Suppl 11:S38-44. PubMed PMID: 15822104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Other pharmacological treatments for motor complications and dyskinesias. A1 - Waters,Cheryl, PY - 2005/4/12/pubmed PY - 2005/8/27/medline PY - 2005/4/12/entrez SP - S38 EP - 44 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 20 Suppl 11 N2 - Controlling motor complications becomes increasingly difficult with disease progression. The "wearing-off" phenomenon is the most-common motor fluctuation. Wearing-off can be treated by dietary manipulation, shortening the dosing interval, substituting sustained-release levodopa, adding amantadine, or monoamine oxidase type B inhibitors, and other options, including catechol-O-methyltransferase inhibitors and the approved dopamine agonists addressed in another chapter. The rotigotine constant-delivery system is being developed to treat wearing-off symptoms. Istradefylline (KW-6002), an adenosine A(2A) receptor antagonist, has been studied for wearing-off and the results will be discussed. The on-off fluctuations can be treated with liquid levodopa and the rescue therapy of injectable apomorphine. Patients may also suffer from dyskinesias. Dyskinesias can be treated with small doses of liquefied levodopa-carbidopa, amantadine, and clozapine, an atypical neuroleptic. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/15822104/Other_pharmacological_treatments_for_motor_complications_and_dyskinesias_ L2 - https://doi.org/10.1002/mds.20462 DB - PRIME DP - Unbound Medicine ER -