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Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations.
Mov Disord. 2005; 20 Suppl 11:S11-6.MD

Abstract

Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing-off and on-off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The majority of patients, particularly those with young onset of PD, experience these levodopa-related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called "peak-dose dyskinesia", usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less-common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing-off effect. Recognition of the full spectrum of clinical phenomenology of levodopa-related motor complications is essential for their treatment and prevention.

Authors+Show Affiliations

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. josephj@bcm.tmc.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15822109

Citation

Jankovic, Joseph. "Motor Fluctuations and Dyskinesias in Parkinson's Disease: Clinical Manifestations." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 20 Suppl 11, 2005, pp. S11-6.
Jankovic J. Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations. Mov Disord. 2005;20 Suppl 11:S11-6.
Jankovic, J. (2005). Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations. Movement Disorders : Official Journal of the Movement Disorder Society, 20 Suppl 11, S11-6.
Jankovic J. Motor Fluctuations and Dyskinesias in Parkinson's Disease: Clinical Manifestations. Mov Disord. 2005;20 Suppl 11:S11-6. PubMed PMID: 15822109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations. A1 - Jankovic,Joseph, PY - 2005/4/12/pubmed PY - 2005/8/27/medline PY - 2005/4/12/entrez SP - S11 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 20 Suppl 11 N2 - Fluctuations in the symptoms of Parkinson's disease (PD), such as wearing-off and on-off effects, and dyskinesias are related to a variety of factors, including duration and dosage of levodopa, age at onset, stress, sleep, food intake, and other pharmacokinetic and pharmacodynamic mechanisms. The majority of patients, particularly those with young onset of PD, experience these levodopa-related adverse effects after a few years of treatment. Assessment of these motor complications is difficult because of the marked clinical variability between and within patients. Daily diaries have been used in clinical trials designed to assess the effects of various pharmacological and surgical interventions on motor fluctuations and dyskinesias. The most common type of dyskinesia, called "peak-dose dyskinesia", usually consists of stereotypical choreic or ballistic movements involving the head, trunk, and limbs, and occasionally, the respiratory muscles, whereas tremor and punding are less-common complications. Dystonia is also typically seen in patients with diphasic dyskinesia and wearing-off effect. Recognition of the full spectrum of clinical phenomenology of levodopa-related motor complications is essential for their treatment and prevention. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/15822109/Motor_fluctuations_and_dyskinesias_in_Parkinson's_disease:_clinical_manifestations_ L2 - https://doi.org/10.1002/mds.20458 DB - PRIME DP - Unbound Medicine ER -