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Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia.
Brain Res. 2005 Apr 25; 1042(1):108-13.BR

Abstract

Patients with postherpetic neuralgia often have an increased sensitivity to a tactile stimulus but impaired thermal sensitivity in the same affected dermatomes. We recently found that depletion of capsaicin-sensitive afferents by systemic treatment with a potent TRPV1 agonist, resiniferotoxin, in adult rats produces long-lasting paradoxical changes in mechanical and thermal sensitivities, which resemble the unique clinical features of postherpetic neuralgia. The anticonvulsant gabapentin is effective in reducing the subjective pain score in patients with postherpetic neuralgia. In this study, we quantified the potential effect of systemic and intrathecal gabapentin on tactile allodynia induced by resiniferotoxin in rats. Intraperitoneal injection of 200 microg/kg resiniferotoxin produced a rapid and sustained increase in the paw withdrawal latency to a radiant heat stimulus. Profound tactile allodynia developed in all the resiniferotoxin-treated rats within 3 weeks. Intraperitoneal injection of 30-60 mg/kg of gabapentin in resiniferotoxin-treated rats significantly increased the withdrawal threshold in response to von Frey filaments. Furthermore, intrathecal administration of 10-30 microg of gabapentin also produced a significant effect on the mechanical withdrawal threshold in all resiniferotoxin-treated rats. These data provide complementary new information that gabapentin administered systemically and spinally can effectively relieve tactile allodynia in this animal model of postherpetic neuralgia.

Authors+Show Affiliations

Department of Anesthesiology, Pennsylvania State University College of Medicine, The Milton S. Hershey Medical Center, Hershey, PA 17033, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15823259

Citation

Chen, Shao-Rui, and Hui-Lin Pan. "Effect of Systemic and Intrathecal Gabapentin On Allodynia in a New Rat Model of Postherpetic Neuralgia." Brain Research, vol. 1042, no. 1, 2005, pp. 108-13.
Chen SR, Pan HL. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res. 2005;1042(1):108-13.
Chen, S. R., & Pan, H. L. (2005). Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Research, 1042(1), 108-13.
Chen SR, Pan HL. Effect of Systemic and Intrathecal Gabapentin On Allodynia in a New Rat Model of Postherpetic Neuralgia. Brain Res. 2005 Apr 25;1042(1):108-13. PubMed PMID: 15823259.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. AU - Chen,Shao-Rui, AU - Pan,Hui-Lin, PY - 2005/01/03/received PY - 2005/02/10/revised PY - 2005/02/12/accepted PY - 2005/4/13/pubmed PY - 2005/7/20/medline PY - 2005/4/13/entrez SP - 108 EP - 13 JF - Brain research JO - Brain Res VL - 1042 IS - 1 N2 - Patients with postherpetic neuralgia often have an increased sensitivity to a tactile stimulus but impaired thermal sensitivity in the same affected dermatomes. We recently found that depletion of capsaicin-sensitive afferents by systemic treatment with a potent TRPV1 agonist, resiniferotoxin, in adult rats produces long-lasting paradoxical changes in mechanical and thermal sensitivities, which resemble the unique clinical features of postherpetic neuralgia. The anticonvulsant gabapentin is effective in reducing the subjective pain score in patients with postherpetic neuralgia. In this study, we quantified the potential effect of systemic and intrathecal gabapentin on tactile allodynia induced by resiniferotoxin in rats. Intraperitoneal injection of 200 microg/kg resiniferotoxin produced a rapid and sustained increase in the paw withdrawal latency to a radiant heat stimulus. Profound tactile allodynia developed in all the resiniferotoxin-treated rats within 3 weeks. Intraperitoneal injection of 30-60 mg/kg of gabapentin in resiniferotoxin-treated rats significantly increased the withdrawal threshold in response to von Frey filaments. Furthermore, intrathecal administration of 10-30 microg of gabapentin also produced a significant effect on the mechanical withdrawal threshold in all resiniferotoxin-treated rats. These data provide complementary new information that gabapentin administered systemically and spinally can effectively relieve tactile allodynia in this animal model of postherpetic neuralgia. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/15823259/Effect_of_systemic_and_intrathecal_gabapentin_on_allodynia_in_a_new_rat_model_of_postherpetic_neuralgia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(05)00271-4 DB - PRIME DP - Unbound Medicine ER -