Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy.Parkinsonism Relat Disord. 2005 May; 11(3):151-5.PR
Abstract
The aim of the study was to investigate the relationship between dyskinesias and motor fluctuations in patients with Parkinson's disease on l-dopa monotherapy. We identified 116 patients on l-dopa monotherapy treated between 1965 and 1992 and followed until death. Dyskinesias occurred in 102 patients. Of these, 48 only developed dyskinesias while 54 had both dyskinesias and motor fluctuations. Among patients with both complications, 49 developed dyskinesias before fluctuations, and only five had dyskinesias after the onset of fluctuations. Our findings suggest that dyskinesias predict the onset of motor fluctuations, and may share a common pathophysiological mechanism.
MeSH
Pub Type(s)
Journal Article
Language
eng
PubMed ID
15823479
Citation
Mazzella, L, et al. "Dyskinesias Predict the Onset of Motor Response Fluctuations in Patients With Parkinson's Disease On L-dopa Monotherapy." Parkinsonism & Related Disorders, vol. 11, no. 3, 2005, pp. 151-5.
Mazzella L, Yahr MD, Marinelli L, et al. Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy. Parkinsonism Relat Disord. 2005;11(3):151-5.
Mazzella, L., Yahr, M. D., Marinelli, L., Huang, N., Moshier, E., & Di Rocco, A. (2005). Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy. Parkinsonism & Related Disorders, 11(3), 151-5.
Mazzella L, et al. Dyskinesias Predict the Onset of Motor Response Fluctuations in Patients With Parkinson's Disease On L-dopa Monotherapy. Parkinsonism Relat Disord. 2005;11(3):151-5. PubMed PMID: 15823479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy.
AU - Mazzella,L,
AU - Yahr,M D,
AU - Marinelli,L,
AU - Huang,N,
AU - Moshier,E,
AU - Di Rocco,A,
PY - 2003/10/14/received
PY - 2004/10/06/revised
PY - 2004/10/13/accepted
PY - 2005/4/13/pubmed
PY - 2005/6/18/medline
PY - 2005/4/13/entrez
SP - 151
EP - 5
JF - Parkinsonism & related disorders
JO - Parkinsonism Relat Disord
VL - 11
IS - 3
N2 - The aim of the study was to investigate the relationship between dyskinesias and motor fluctuations in patients with Parkinson's disease on l-dopa monotherapy. We identified 116 patients on l-dopa monotherapy treated between 1965 and 1992 and followed until death. Dyskinesias occurred in 102 patients. Of these, 48 only developed dyskinesias while 54 had both dyskinesias and motor fluctuations. Among patients with both complications, 49 developed dyskinesias before fluctuations, and only five had dyskinesias after the onset of fluctuations. Our findings suggest that dyskinesias predict the onset of motor fluctuations, and may share a common pathophysiological mechanism.
SN - 1353-8020
UR - https://www.unboundmedicine.com/medline/citation/15823479/Dyskinesias_predict_the_onset_of_motor_response_fluctuations_in_patients_with_Parkinson's_disease_on_L_dopa_monotherapy_
DB - PRIME
DP - Unbound Medicine
ER -