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Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy.
Parkinsonism Relat Disord. 2005 May; 11(3):151-5.PR

Abstract

The aim of the study was to investigate the relationship between dyskinesias and motor fluctuations in patients with Parkinson's disease on l-dopa monotherapy. We identified 116 patients on l-dopa monotherapy treated between 1965 and 1992 and followed until death. Dyskinesias occurred in 102 patients. Of these, 48 only developed dyskinesias while 54 had both dyskinesias and motor fluctuations. Among patients with both complications, 49 developed dyskinesias before fluctuations, and only five had dyskinesias after the onset of fluctuations. Our findings suggest that dyskinesias predict the onset of motor fluctuations, and may share a common pathophysiological mechanism.

Authors+Show Affiliations

Mazzella L
Department of Neurology, Beth Israel Medical Center-Albert Einstein College of Medicine, PACC-10 Union Square East #5K, New York, NY 10003, USA.
Yahr MD
No affiliation info available
Marinelli L
No affiliation info available
Huang N
No affiliation info available
Moshier E
No affiliation info available
Di Rocco A
No affiliation info available

MeSH

Age of OnsetAgedAntiparkinson AgentsDyskinesia, Drug-InducedFemaleHumansLevodopaMaleMiddle AgedMotor NeuronsParkinson DiseasePredictive Value of TestsRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15823479

Citation

Mazzella, L, et al. "Dyskinesias Predict the Onset of Motor Response Fluctuations in Patients With Parkinson's Disease On L-dopa Monotherapy." Parkinsonism & Related Disorders, vol. 11, no. 3, 2005, pp. 151-5.
Mazzella L, Yahr MD, Marinelli L, et al. Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy. Parkinsonism Relat Disord. 2005;11(3):151-5.
Mazzella, L., Yahr, M. D., Marinelli, L., Huang, N., Moshier, E., & Di Rocco, A. (2005). Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy. Parkinsonism & Related Disorders, 11(3), 151-5.
Mazzella L, et al. Dyskinesias Predict the Onset of Motor Response Fluctuations in Patients With Parkinson's Disease On L-dopa Monotherapy. Parkinsonism Relat Disord. 2005;11(3):151-5. PubMed PMID: 15823479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dyskinesias predict the onset of motor response fluctuations in patients with Parkinson's disease on L-dopa monotherapy. AU - Mazzella,L, AU - Yahr,M D, AU - Marinelli,L, AU - Huang,N, AU - Moshier,E, AU - Di Rocco,A, PY - 2003/10/14/received PY - 2004/10/06/revised PY - 2004/10/13/accepted PY - 2005/4/13/pubmed PY - 2005/6/18/medline PY - 2005/4/13/entrez SP - 151 EP - 5 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 11 IS - 3 N2 - The aim of the study was to investigate the relationship between dyskinesias and motor fluctuations in patients with Parkinson's disease on l-dopa monotherapy. We identified 116 patients on l-dopa monotherapy treated between 1965 and 1992 and followed until death. Dyskinesias occurred in 102 patients. Of these, 48 only developed dyskinesias while 54 had both dyskinesias and motor fluctuations. Among patients with both complications, 49 developed dyskinesias before fluctuations, and only five had dyskinesias after the onset of fluctuations. Our findings suggest that dyskinesias predict the onset of motor fluctuations, and may share a common pathophysiological mechanism. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/15823479/Dyskinesias_predict_the_onset_of_motor_response_fluctuations_in_patients_with_Parkinson's_disease_on_L_dopa_monotherapy_ DB - PRIME DP - Unbound Medicine ER -