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Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers.
Int J Cardiol 2005; 100(2):207-12IJ

Abstract

OBJECTIVE

To relate levels of vascular endothelial growth factor (VEGF) and its soluble receptor, sFlt-1, with endothelial function in healthy smokers.

METHODS

Plasma levels of VEGF and sFlt-1 were measured by ELISA in 22 healthy smokers and 22 matched healthy non-smoking controls, and compared to flow- (FMD) and acetylcholine-mediated (AMD) vasodilatation (endothelial-dependent) (EDV) and nitroglycerine-mediated (NMD) vasodilatation (endothelial-independent) of lower extremities were measured with plethysmography.

RESULTS

Smokers and controls had similar plasma VEGF levels, but sFlt-1 levels were lower in smokers than in controls (p<0.01). AMD was lower in smokers compared to controls (p<0.05), but FMD and NMD levels were similar. Smokers and controls with high AMD (>12 ml/100 ml tissue/min) had significantly lower plasma VEGF levels (p<0.001). An inverse correlation was found in both groups, between VEGF and AMD (smokers: r=-0.6, p<0.01; controls: r=-0.71, p<0.005) and with FMD (smokers: r=-0.56, p<0.05; controls: r=-0.58, p<0.005). There were no significant correlations between sFlt-1 with VEGF levels or endothelial-dependent dilatation.

CONCLUSION

In conclusion, healthy smokers demonstrate abnormal AMD, and an inverse correlation between plasma VEGF levels (but not sFlt-1) with indices of endothelial dysfunction (FMD and AMD) exists. VEGF, and not sFlt-1, may be related to the pathogenesis of endothelial dysfunction in healthy smoking individuals.

Authors+Show Affiliations

Department of Internal Medicine, Division of Cardiology, Angiology and Pneumology, Otto-von-Guericke University, Magdeburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15823626

Citation

Schmidt-Lucke, Caroline, et al. "Soluble Vascular Endothelial Growth Factor, Soluble VEGF Receptor Flt-1 and Endothelial Function in Healthy Smokers." International Journal of Cardiology, vol. 100, no. 2, 2005, pp. 207-12.
Schmidt-Lucke C, Belgore F, Reinhold D, et al. Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers. Int J Cardiol. 2005;100(2):207-12.
Schmidt-Lucke, C., Belgore, F., Reinhold, D., Ansorge, S., Klein, H. U., Schmidt-Lucke, J. A., & Lip, G. Y. (2005). Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers. International Journal of Cardiology, 100(2), pp. 207-12.
Schmidt-Lucke C, et al. Soluble Vascular Endothelial Growth Factor, Soluble VEGF Receptor Flt-1 and Endothelial Function in Healthy Smokers. Int J Cardiol. 2005 Apr 20;100(2):207-12. PubMed PMID: 15823626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soluble vascular endothelial growth factor, soluble VEGF receptor Flt-1 and endothelial function in healthy smokers. AU - Schmidt-Lucke,Caroline, AU - Belgore,Funmi, AU - Reinhold,Dirk, AU - Ansorge,Siegfried, AU - Klein,Helmut U, AU - Schmidt-Lucke,J André, AU - Lip,Gregory Y H, PY - 2004/01/21/received PY - 2004/04/28/revised PY - 2004/05/05/accepted PY - 2005/4/13/pubmed PY - 2005/7/26/medline PY - 2005/4/13/entrez SP - 207 EP - 12 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 100 IS - 2 N2 - OBJECTIVE: To relate levels of vascular endothelial growth factor (VEGF) and its soluble receptor, sFlt-1, with endothelial function in healthy smokers. METHODS: Plasma levels of VEGF and sFlt-1 were measured by ELISA in 22 healthy smokers and 22 matched healthy non-smoking controls, and compared to flow- (FMD) and acetylcholine-mediated (AMD) vasodilatation (endothelial-dependent) (EDV) and nitroglycerine-mediated (NMD) vasodilatation (endothelial-independent) of lower extremities were measured with plethysmography. RESULTS: Smokers and controls had similar plasma VEGF levels, but sFlt-1 levels were lower in smokers than in controls (p<0.01). AMD was lower in smokers compared to controls (p<0.05), but FMD and NMD levels were similar. Smokers and controls with high AMD (>12 ml/100 ml tissue/min) had significantly lower plasma VEGF levels (p<0.001). An inverse correlation was found in both groups, between VEGF and AMD (smokers: r=-0.6, p<0.01; controls: r=-0.71, p<0.005) and with FMD (smokers: r=-0.56, p<0.05; controls: r=-0.58, p<0.005). There were no significant correlations between sFlt-1 with VEGF levels or endothelial-dependent dilatation. CONCLUSION: In conclusion, healthy smokers demonstrate abnormal AMD, and an inverse correlation between plasma VEGF levels (but not sFlt-1) with indices of endothelial dysfunction (FMD and AMD) exists. VEGF, and not sFlt-1, may be related to the pathogenesis of endothelial dysfunction in healthy smoking individuals. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15823626/Soluble_vascular_endothelial_growth_factor_soluble_VEGF_receptor_Flt_1_and_endothelial_function_in_healthy_smokers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(04)00541-8 DB - PRIME DP - Unbound Medicine ER -