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Effects of switching statins on lipid and apolipoprotein ratios in the MERCURY I study.
Int J Cardiol. 2005 Apr 20; 100(2):309-16.IJ

Abstract

BACKGROUND

Lipid ratios are clinically useful markers of coronary artery disease (CAD) risk. The effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on lipid ratios were investigated in the Measuring Effective Reductions in Cholesterol Using Rosuvastatin TherapY (MERCURY) I trial.

METHODS

This trial was conducted in 3140 hypercholesterolemic patients with CAD, atherosclerosis, type 2 diabetes mellitus, or a 20% 10-year risk for CAD. Patients were randomized to rosuvastatin 10 mg, atorvastatin 10 or 20 mg, simvastatin 20 mg, or pravastatin 40 mg for 8 weeks; all patients except those receiving rosuvastatin 10 mg either were switched to rosuvastatin 10 or 20 mg or remained on initial treatment for 8 more weeks.

RESULTS

At 8 weeks, reductions in total cholesterol (TC):high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol:HDL-C, non-HDL-C:HDL-C, and apolipoprotein (apo) B:apo A-I ratios with rosuvastatin 10 mg were significantly greater than those with atorvastatin 10 mg, atorvastatin 20 mg, simvastatin 20 mg, and pravastatin 40 mg (P<0.0001 for all). At week 16, switching to rosuvastatin 10 mg from atorvastatin 10 mg, simvastatin 20 mg, and pravastatin 40 mg and to rosuvastatin 20 mg from atorvastatin 20 mg produced significantly greater reductions in all lipid ratios (P< or =0.0001 for all). Switching to rosuvastatin 10 mg from atorvastatin 20 mg produced significantly greater reductions in TC:HDL-C (P<0.025) and apo B:apo A-I (P<0.01).

CONCLUSIONS

Rosuvastatin 10 mg reduces lipid ratios more than equivalent and higher doses of other statins; switching to equal or lower doses of rosuvastatin produces significantly improved reductions in lipid ratios.

Authors+Show Affiliations

Southwestern Ontario Medical Education Network Windsor, Schulich School of Medicine, University of Western Ontario, Canada. raphael.cheung@fmd.uwo.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15823640

Citation

Cheung, Raphael C., et al. "Effects of Switching Statins On Lipid and Apolipoprotein Ratios in the MERCURY I Study." International Journal of Cardiology, vol. 100, no. 2, 2005, pp. 309-16.
Cheung RC, Morrell JM, Kallend D, et al. Effects of switching statins on lipid and apolipoprotein ratios in the MERCURY I study. Int J Cardiol. 2005;100(2):309-16.
Cheung, R. C., Morrell, J. M., Kallend, D., Watkins, C., & Schuster, H. (2005). Effects of switching statins on lipid and apolipoprotein ratios in the MERCURY I study. International Journal of Cardiology, 100(2), 309-16.
Cheung RC, et al. Effects of Switching Statins On Lipid and Apolipoprotein Ratios in the MERCURY I Study. Int J Cardiol. 2005 Apr 20;100(2):309-16. PubMed PMID: 15823640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of switching statins on lipid and apolipoprotein ratios in the MERCURY I study. AU - Cheung,Raphael C, AU - Morrell,Jonathan M, AU - Kallend,David, AU - Watkins,Claire, AU - Schuster,Herbert, PY - 2004/04/22/received PY - 2004/11/10/revised PY - 2004/12/30/accepted PY - 2005/4/13/pubmed PY - 2005/7/26/medline PY - 2005/4/13/entrez SP - 309 EP - 16 JF - International journal of cardiology JO - Int J Cardiol VL - 100 IS - 2 N2 - BACKGROUND: Lipid ratios are clinically useful markers of coronary artery disease (CAD) risk. The effects of rosuvastatin, atorvastatin, simvastatin, and pravastatin on lipid ratios were investigated in the Measuring Effective Reductions in Cholesterol Using Rosuvastatin TherapY (MERCURY) I trial. METHODS: This trial was conducted in 3140 hypercholesterolemic patients with CAD, atherosclerosis, type 2 diabetes mellitus, or a 20% 10-year risk for CAD. Patients were randomized to rosuvastatin 10 mg, atorvastatin 10 or 20 mg, simvastatin 20 mg, or pravastatin 40 mg for 8 weeks; all patients except those receiving rosuvastatin 10 mg either were switched to rosuvastatin 10 or 20 mg or remained on initial treatment for 8 more weeks. RESULTS: At 8 weeks, reductions in total cholesterol (TC):high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol:HDL-C, non-HDL-C:HDL-C, and apolipoprotein (apo) B:apo A-I ratios with rosuvastatin 10 mg were significantly greater than those with atorvastatin 10 mg, atorvastatin 20 mg, simvastatin 20 mg, and pravastatin 40 mg (P<0.0001 for all). At week 16, switching to rosuvastatin 10 mg from atorvastatin 10 mg, simvastatin 20 mg, and pravastatin 40 mg and to rosuvastatin 20 mg from atorvastatin 20 mg produced significantly greater reductions in all lipid ratios (P< or =0.0001 for all). Switching to rosuvastatin 10 mg from atorvastatin 20 mg produced significantly greater reductions in TC:HDL-C (P<0.025) and apo B:apo A-I (P<0.01). CONCLUSIONS: Rosuvastatin 10 mg reduces lipid ratios more than equivalent and higher doses of other statins; switching to equal or lower doses of rosuvastatin produces significantly improved reductions in lipid ratios. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15823640/Effects_of_switching_statins_on_lipid_and_apolipoprotein_ratios_in_the_MERCURY_I_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00145-2 DB - PRIME DP - Unbound Medicine ER -