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Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study.
Eur Heart J. 2005 Jun; 26(12):1213-20.EH

Abstract

AIMS

To study whether arterial stiffness is related to risk of new vascular events in patients with manifest arterial disease and to examine whether this relation varies between patients who differ with respect to baseline vascular risk, arterial stiffness, or systolic blood pressure (SBP).

METHODS AND RESULTS

The study was performed in the first consecutive 2183 patients with manifest arterial disease enrolled in the SMART study (Second Manifestations of ARTerial disease), a cohort study among patients with manifest arterial disease or cardiovascular risk factors. Common carotid distension (i.e. the change in carotid diameter in systole relative to diastole) was measured at baseline by ultrasonography. With the distension, several stiffness parameters were determined. In the entire cohort, none of the carotid artery stiffness parameters was related to the occurrence of vascular events. However, decreased stiffness was related to decreased vascular risk in subjects with low baseline SBP. The relation of carotid stiffness with vascular events did not differ between tertiles of baseline risk and carotid stiffness.

CONCLUSION

Carotid artery stiffness is no independent risk factor for vascular events in patients with manifest arterial disease. However, in patients with low SBP, decreased carotid stiffness may indicate a decreased risk of vascular events.

Authors+Show Affiliations

Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Huispostnummer Str. 6.131, PO Box 85060, 3508 BA Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15824075

Citation

Dijk, Joke M., et al. "Carotid Stiffness and the Risk of New Vascular Events in Patients With Manifest Cardiovascular Disease. the SMART Study." European Heart Journal, vol. 26, no. 12, 2005, pp. 1213-20.
Dijk JM, Algra A, van der Graaf Y, et al. Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study. Eur Heart J. 2005;26(12):1213-20.
Dijk, J. M., Algra, A., van der Graaf, Y., Grobbee, D. E., & Bots, M. L. (2005). Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study. European Heart Journal, 26(12), 1213-20.
Dijk JM, et al. Carotid Stiffness and the Risk of New Vascular Events in Patients With Manifest Cardiovascular Disease. the SMART Study. Eur Heart J. 2005;26(12):1213-20. PubMed PMID: 15824075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study. AU - Dijk,Joke M, AU - Algra,Ale, AU - van der Graaf,Yolanda, AU - Grobbee,Diederick E, AU - Bots,Michiel L, AU - ,, Y1 - 2005/04/11/ PY - 2005/4/13/pubmed PY - 2005/9/30/medline PY - 2005/4/13/entrez SP - 1213 EP - 20 JF - European heart journal JO - Eur Heart J VL - 26 IS - 12 N2 - AIMS: To study whether arterial stiffness is related to risk of new vascular events in patients with manifest arterial disease and to examine whether this relation varies between patients who differ with respect to baseline vascular risk, arterial stiffness, or systolic blood pressure (SBP). METHODS AND RESULTS: The study was performed in the first consecutive 2183 patients with manifest arterial disease enrolled in the SMART study (Second Manifestations of ARTerial disease), a cohort study among patients with manifest arterial disease or cardiovascular risk factors. Common carotid distension (i.e. the change in carotid diameter in systole relative to diastole) was measured at baseline by ultrasonography. With the distension, several stiffness parameters were determined. In the entire cohort, none of the carotid artery stiffness parameters was related to the occurrence of vascular events. However, decreased stiffness was related to decreased vascular risk in subjects with low baseline SBP. The relation of carotid stiffness with vascular events did not differ between tertiles of baseline risk and carotid stiffness. CONCLUSION: Carotid artery stiffness is no independent risk factor for vascular events in patients with manifest arterial disease. However, in patients with low SBP, decreased carotid stiffness may indicate a decreased risk of vascular events. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/15824075/Carotid_stiffness_and_the_risk_of_new_vascular_events_in_patients_with_manifest_cardiovascular_disease__The_SMART_study_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehi254 DB - PRIME DP - Unbound Medicine ER -