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Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma.
Arch Ophthalmol. 2005 Apr; 123(4):464-70.AO

Abstract

OBJECTIVES

To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry.

METHODS

Retrospective evaluation of 64 eyes (37 patients) of glaucoma suspects or patients with glaucoma participating in a prospective longitudinal study. All participants underwent comprehensive clinical assessment, visual field (VF) testing, and OCT every 6 months. Field progression was defined as a reproducible decline of at least 2 dB in VF mean deviation from baseline. Progression of OCT was defined as reproducible mean retinal nerve fiber layer thinning of at least 20 mum.

RESULTS

Each patient had a median of 5 usable OCT scans at median follow-up of 4.7 years. The difference in the linear regression slopes of retinal nerve fiber layer thickness between glaucoma suspects and patients with glaucoma was nonsignificant for all variables; however, Kaplan-Meier survival curve analysis demonstrated a higher progression rate by OCT vs VF. Sixty-six percent of eyes were stable throughout follow-up, whereas 22% progressed by OCT alone, 9% by VF mean deviation alone, and 3% by VF and OCT.

CONCLUSIONS

A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods.

Authors+Show Affiliations

New England Eye Center, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Mass., USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15824218

Citation

Wollstein, Gadi, et al. "Optical Coherence Tomography Longitudinal Evaluation of Retinal Nerve Fiber Layer Thickness in Glaucoma." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 123, no. 4, 2005, pp. 464-70.
Wollstein G, Schuman JS, Price LL, et al. Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma. Arch Ophthalmol. 2005;123(4):464-70.
Wollstein, G., Schuman, J. S., Price, L. L., Aydin, A., Stark, P. C., Hertzmark, E., Lai, E., Ishikawa, H., Mattox, C., Fujimoto, J. G., & Paunescu, L. A. (2005). Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma. Archives of Ophthalmology (Chicago, Ill. : 1960), 123(4), 464-70.
Wollstein G, et al. Optical Coherence Tomography Longitudinal Evaluation of Retinal Nerve Fiber Layer Thickness in Glaucoma. Arch Ophthalmol. 2005;123(4):464-70. PubMed PMID: 15824218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma. AU - Wollstein,Gadi, AU - Schuman,Joel S, AU - Price,Lori L, AU - Aydin,Ali, AU - Stark,Paul C, AU - Hertzmark,Ellen, AU - Lai,Edward, AU - Ishikawa,Hiroshi, AU - Mattox,Cynthia, AU - Fujimoto,James G, AU - Paunescu,Lelia A, PY - 2005/4/13/pubmed PY - 2005/4/20/medline PY - 2005/4/13/entrez SP - 464 EP - 70 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 123 IS - 4 N2 - OBJECTIVES: To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry. METHODS: Retrospective evaluation of 64 eyes (37 patients) of glaucoma suspects or patients with glaucoma participating in a prospective longitudinal study. All participants underwent comprehensive clinical assessment, visual field (VF) testing, and OCT every 6 months. Field progression was defined as a reproducible decline of at least 2 dB in VF mean deviation from baseline. Progression of OCT was defined as reproducible mean retinal nerve fiber layer thinning of at least 20 mum. RESULTS: Each patient had a median of 5 usable OCT scans at median follow-up of 4.7 years. The difference in the linear regression slopes of retinal nerve fiber layer thickness between glaucoma suspects and patients with glaucoma was nonsignificant for all variables; however, Kaplan-Meier survival curve analysis demonstrated a higher progression rate by OCT vs VF. Sixty-six percent of eyes were stable throughout follow-up, whereas 22% progressed by OCT alone, 9% by VF mean deviation alone, and 3% by VF and OCT. CONCLUSIONS: A greater likelihood of glaucomatous progression was identified by OCT vs automated perimetry. This might reflect OCT hypersensitivity or true damage identified by OCT before detection by conventional methods. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/15824218/Optical_coherence_tomography_longitudinal_evaluation_of_retinal_nerve_fiber_layer_thickness_in_glaucoma_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.123.4.464 DB - PRIME DP - Unbound Medicine ER -