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Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons.
Arch Neurol 2005; 62(4):641-5AN

Abstract

BACKGROUND

Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease.

OBJECTIVE

To examine the association between rates of age-related cognitive change and dietary intakes of folate and vitamin B12.

DESIGN

Prospective study performed from 1993 to 2002.

SETTING

Geographically defined biracial community in Chicago, Ill.

PARTICIPANTS

A total of 3718 residents, 65 years and older, who completed 2 to 3 cognitive assessments and a food frequency questionnaire.

MAIN OUTCOME MEASURE

Change in cognitive function measured at baseline and 3-year and 6-year follow-ups, using the average z score of 4 tests: the East Boston Tests of immediate and delayed recall, the Mini-Mental State Examination, and the Symbol Digit Modalities Test.

RESULTS

High folate intake was associated with a faster rate of cognitive decline in mixed models adjusted for multiple risk factors. The rate of cognitive decline among persons in the top fifth of total folate intake (median, 742 microg/d) was more than twice that of those in the lowest fifth of intake (median, 186 microg/d), a statistically significant difference of 0.02 standardized unit per year (P = .002). A faster rate of cognitive decline was also associated with high folate intake from food (P for trend = .04) and with folate vitamin supplementation of more than 400 microg/d compared with nonusers (beta = -.03, P<.001). High total B12 intake was associated with slower cognitive decline only among the oldest participants.

CONCLUSIONS

High intake of folate may be associated with cognitive decline in older persons. These unexpected findings call for further study of the cognitive implications of high levels of dietary folate in older populations.

Authors+Show Affiliations

Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Ill 60612, USA. Martha_C_Morris@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15824266

Citation

Morris, Martha Clare, et al. "Dietary Folate and Vitamin B12 Intake and Cognitive Decline Among Community-dwelling Older Persons." Archives of Neurology, vol. 62, no. 4, 2005, pp. 641-5.
Morris MC, Evans DA, Bienias JL, et al. Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Arch Neurol. 2005;62(4):641-5.
Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Hebert, L. E., Scherr, P. A., & Schneider, J. A. (2005). Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. Archives of Neurology, 62(4), pp. 641-5.
Morris MC, et al. Dietary Folate and Vitamin B12 Intake and Cognitive Decline Among Community-dwelling Older Persons. Arch Neurol. 2005;62(4):641-5. PubMed PMID: 15824266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate and vitamin B12 intake and cognitive decline among community-dwelling older persons. AU - Morris,Martha Clare, AU - Evans,Denis A, AU - Bienias,Julia L, AU - Tangney,Christine C, AU - Hebert,Liesi E, AU - Scherr,Paul A, AU - Schneider,Julie A, PY - 2005/4/13/pubmed PY - 2005/5/11/medline PY - 2005/4/13/entrez SP - 641 EP - 5 JF - Archives of neurology JO - Arch. Neurol. VL - 62 IS - 4 N2 - BACKGROUND: Deficiencies in folate and vitamin B12 have been associated with neurodegenerative disease. OBJECTIVE: To examine the association between rates of age-related cognitive change and dietary intakes of folate and vitamin B12. DESIGN: Prospective study performed from 1993 to 2002. SETTING: Geographically defined biracial community in Chicago, Ill. PARTICIPANTS: A total of 3718 residents, 65 years and older, who completed 2 to 3 cognitive assessments and a food frequency questionnaire. MAIN OUTCOME MEASURE: Change in cognitive function measured at baseline and 3-year and 6-year follow-ups, using the average z score of 4 tests: the East Boston Tests of immediate and delayed recall, the Mini-Mental State Examination, and the Symbol Digit Modalities Test. RESULTS: High folate intake was associated with a faster rate of cognitive decline in mixed models adjusted for multiple risk factors. The rate of cognitive decline among persons in the top fifth of total folate intake (median, 742 microg/d) was more than twice that of those in the lowest fifth of intake (median, 186 microg/d), a statistically significant difference of 0.02 standardized unit per year (P = .002). A faster rate of cognitive decline was also associated with high folate intake from food (P for trend = .04) and with folate vitamin supplementation of more than 400 microg/d compared with nonusers (beta = -.03, P<.001). High total B12 intake was associated with slower cognitive decline only among the oldest participants. CONCLUSIONS: High intake of folate may be associated with cognitive decline in older persons. These unexpected findings call for further study of the cognitive implications of high levels of dietary folate in older populations. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/15824266/Dietary_folate_and_vitamin_B12_intake_and_cognitive_decline_among_community_dwelling_older_persons_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.62.4.641 DB - PRIME DP - Unbound Medicine ER -