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Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study.
Arch Intern Med. 2005 Apr 11; 165(7):742-8.AI

Abstract

BACKGROUND

Limited prospective information exists on the relation between obesity and weight change and the risk of gout. Similarly, both hypertension and diuretic use have been considered risk factors for gout; however, their independent contributions have not been established prospectively.

METHODS

We prospectively examined over a 12-year period (1986-1998) the relation between adiposity, weight change, hypertension, and diuretic use and incident gout in 47,150 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout.

RESULTS

During 12 years we documented 730 confirmed incident cases of gout. Compared with men with a body mass index (BMI) of 21 to 22.9, the multivariate relative risks (RRs) of gout were 1.95 (95% confidence interval [CI], 1.44-2.65) for men with a BMI of 25 to 29.9, 2.33 (95% CI, 1.62-3.36) for men with a BMI of 30 to 34.9, and 2.97 (95% CI, 1.73-5.10) for men with a BMI of 35 or greater (P for trend <.001). Compared with men who had maintained their weight (+/-4 lb) since age 21 years, the multivariate RR of gout for men who had gained 30 lb or more since age 21 years was 1.99 (95% CI, 1.49-2.66). In contrast, the multivariate RR for men who had lost 10 lb or more since the study baseline was 0.61 (95% CI, 0.40-0.92). The multivariate RRs of gout were 2.31 (95% CI, 1.96-2.72) for the presence of hypertension and 1.77 (95% CI, 1.42-2.20) for diuretic use.

CONCLUSIONS

Higher adiposity and weight gain are strong risk factors for gout in men, while weight loss is protective. Hypertension and diuretic use are also important independent risk factors for gout.

Authors+Show Affiliations

Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, MA 02114, USA. hchoi@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15824292

Citation

Choi, Hyon K., et al. "Obesity, Weight Change, Hypertension, Diuretic Use, and Risk of Gout in Men: the Health Professionals Follow-up Study." Archives of Internal Medicine, vol. 165, no. 7, 2005, pp. 742-8.
Choi HK, Atkinson K, Karlson EW, et al. Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. Arch Intern Med. 2005;165(7):742-8.
Choi, H. K., Atkinson, K., Karlson, E. W., & Curhan, G. (2005). Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. Archives of Internal Medicine, 165(7), 742-8.
Choi HK, et al. Obesity, Weight Change, Hypertension, Diuretic Use, and Risk of Gout in Men: the Health Professionals Follow-up Study. Arch Intern Med. 2005 Apr 11;165(7):742-8. PubMed PMID: 15824292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. AU - Choi,Hyon K, AU - Atkinson,Karen, AU - Karlson,Elizabeth W, AU - Curhan,Gary, PY - 2005/4/13/pubmed PY - 2005/5/6/medline PY - 2005/4/13/entrez SP - 742 EP - 8 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 165 IS - 7 N2 - BACKGROUND: Limited prospective information exists on the relation between obesity and weight change and the risk of gout. Similarly, both hypertension and diuretic use have been considered risk factors for gout; however, their independent contributions have not been established prospectively. METHODS: We prospectively examined over a 12-year period (1986-1998) the relation between adiposity, weight change, hypertension, and diuretic use and incident gout in 47,150 male participants with no history of gout at baseline. We used a supplementary questionnaire to ascertain the American College of Rheumatology criteria for gout. RESULTS: During 12 years we documented 730 confirmed incident cases of gout. Compared with men with a body mass index (BMI) of 21 to 22.9, the multivariate relative risks (RRs) of gout were 1.95 (95% confidence interval [CI], 1.44-2.65) for men with a BMI of 25 to 29.9, 2.33 (95% CI, 1.62-3.36) for men with a BMI of 30 to 34.9, and 2.97 (95% CI, 1.73-5.10) for men with a BMI of 35 or greater (P for trend <.001). Compared with men who had maintained their weight (+/-4 lb) since age 21 years, the multivariate RR of gout for men who had gained 30 lb or more since age 21 years was 1.99 (95% CI, 1.49-2.66). In contrast, the multivariate RR for men who had lost 10 lb or more since the study baseline was 0.61 (95% CI, 0.40-0.92). The multivariate RRs of gout were 2.31 (95% CI, 1.96-2.72) for the presence of hypertension and 1.77 (95% CI, 1.42-2.20) for diuretic use. CONCLUSIONS: Higher adiposity and weight gain are strong risk factors for gout in men, while weight loss is protective. Hypertension and diuretic use are also important independent risk factors for gout. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/15824292/Obesity_weight_change_hypertension_diuretic_use_and_risk_of_gout_in_men:_the_health_professionals_follow_up_study_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinte.165.7.742 DB - PRIME DP - Unbound Medicine ER -