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Evidence of increased oxidative damage in subjects with mild cognitive impairment.
Neurology 2005; 64(7):1152-6Neur

Abstract

OBJECTIVE

To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD).

METHODS

The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD.

RESULTS

Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined.

CONCLUSION

Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease.

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    Authors+Show Affiliations

    Keller JN
    Department of Anatomy, University of Kentucky, Lexington 40536-0230, USA. Jnkell0@pop.uky.edu
    Schmitt FA
    No affiliation info available
    Scheff SW
    No affiliation info available
    Ding Q
    No affiliation info available
    Chen Q
    No affiliation info available
    Butterfield DA
    No affiliation info available
    Markesbery WR
    No affiliation info available

    MeSH

    AgedAged, 80 and overAlzheimer DiseaseBrainCognition DisordersDisease ProgressionFemaleFree RadicalsHumansMaleMalondialdehydeMemory DisordersNerve DegenerationNeuropsychological TestsOxidative StressPlaque, AmyloidPredictive Value of TestsProtein CarbonylationThiobarbituric Acid Reactive SubstancesUp-Regulation

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15824339

    Citation

    Keller, J N., et al. "Evidence of Increased Oxidative Damage in Subjects With Mild Cognitive Impairment." Neurology, vol. 64, no. 7, 2005, pp. 1152-6.
    Keller JN, Schmitt FA, Scheff SW, et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology. 2005;64(7):1152-6.
    Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005). Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology, 64(7), pp. 1152-6.
    Keller JN, et al. Evidence of Increased Oxidative Damage in Subjects With Mild Cognitive Impairment. Neurology. 2005 Apr 12;64(7):1152-6. PubMed PMID: 15824339.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evidence of increased oxidative damage in subjects with mild cognitive impairment. AU - Keller,J N, AU - Schmitt,F A, AU - Scheff,S W, AU - Ding,Q, AU - Chen,Q, AU - Butterfield,D A, AU - Markesbery,W R, PY - 2005/4/13/pubmed PY - 2006/2/14/medline PY - 2005/4/13/entrez SP - 1152 EP - 6 JF - Neurology JO - Neurology VL - 64 IS - 7 N2 - OBJECTIVE: To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS: The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD. RESULTS: Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined. CONCLUSION: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15824339/Evidence_of_increased_oxidative_damage_in_subjects_with_mild_cognitive_impairment_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15824339 DB - PRIME DP - Unbound Medicine ER -