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Evidence of increased oxidative damage in subjects with mild cognitive impairment.
Neurology. 2005 Apr 12; 64(7):1152-6.Neur

Abstract

OBJECTIVE

To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD).

METHODS

The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD.

RESULTS

Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined.

CONCLUSION

Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease.

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Authors+Show Affiliations

Keller JN
Department of Anatomy, University of Kentucky, Lexington 40536-0230, USA. Jnkell0@pop.uky.edu
Schmitt FA
No affiliation info available
Scheff SW
No affiliation info available
Ding Q
No affiliation info available
Chen Q
No affiliation info available
Butterfield DA
No affiliation info available
Markesbery WR
No affiliation info available

MeSH

AgedAged, 80 and overAlzheimer DiseaseBrainCognition DisordersDisease ProgressionFemaleFree RadicalsHumansMaleMalondialdehydeMemory DisordersNerve DegenerationNeuropsychological TestsOxidative StressPlaque, AmyloidPredictive Value of TestsProtein CarbonylationThiobarbituric Acid Reactive SubstancesUp-Regulation

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15824339

Citation

Keller, J N., et al. "Evidence of Increased Oxidative Damage in Subjects With Mild Cognitive Impairment." Neurology, vol. 64, no. 7, 2005, pp. 1152-6.
Keller JN, Schmitt FA, Scheff SW, et al. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology. 2005;64(7):1152-6.
Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005). Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology, 64(7), 1152-6.
Keller JN, et al. Evidence of Increased Oxidative Damage in Subjects With Mild Cognitive Impairment. Neurology. 2005 Apr 12;64(7):1152-6. PubMed PMID: 15824339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of increased oxidative damage in subjects with mild cognitive impairment. AU - Keller,J N, AU - Schmitt,F A, AU - Scheff,S W, AU - Ding,Q, AU - Chen,Q, AU - Butterfield,D A, AU - Markesbery,W R, PY - 2005/4/13/pubmed PY - 2006/2/14/medline PY - 2005/4/13/entrez SP - 1152 EP - 6 JF - Neurology JO - Neurology VL - 64 IS - 7 N2 - OBJECTIVE: To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS: The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD. RESULTS: Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined. CONCLUSION: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15824339/Evidence_of_increased_oxidative_damage_in_subjects_with_mild_cognitive_impairment_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15824339 DB - PRIME DP - Unbound Medicine ER -