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Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women.
J Bone Miner Res 2005; 20(5):741-7JB

Abstract

We studied whether oophorectomy performed after menopause is associated with an increased risk of hip or vertebral fractures in 6295 Study of Osteoporotic Fractures participants. There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures.

INTRODUCTION

Bilateral oophorectomy after natural menopause has been associated with an increased risk of osteoporotic fractures, potentially because of a decline in serum estradiol and testosterone levels after the oophorectomy. We prospectively tested this hypothesis in the Study of Osteoporotic Fractures (SOF).

MATERIALS AND METHODS

We studied 6295 white women 65 years of age participating in the SOF who were not taking estrogen therapy at baseline. Hip fracture analyses included 708 hip fractures; vertebral fracture analyses included 267 incident vertebral fractures. Baseline serum estradiol and free testosterone values were available in a small subset of participants.

RESULTS AND CONCLUSION

There were no significant differences in age, weight, or BMD between the women who underwent postmenopausal oophorectomy (n = 583) and those who did not (n = 5712). Free testosterone levels were significantly lower among women who had a postmenopausal oophorectomy. A history of postmenopausal oophorectomy was not associated with an increased risk of hip (hazard ratio [HR] = 1.1; 95% CI = 0.9-1.5) or vertebral fracture (HR = 0.7; 95% CI = 0.5-1.2). The relationship between oophorectomy and hip fracture was not altered by adding serum estradiol level (HR = 1.3; 95% CI = 0.5-3.2) or serum free testosterone level (HR = 1.7; 95% CI = 0.8-3.7) to the model. In summary, postmenopausal oophorectomy was not associated with an increased risk of hip or vertebral fracture in this cohort. These results are in contrast to previous findings, suggesting that the relationship between postmenopausal oophorectomy and fractures is not fully elucidated and that incidental oophorectomy after menopause should still be considered carefully in each potential patient.

Authors+Show Affiliations

Division of Endocrinology, Department of Medicine, University of California, San Francisco, California 94105, USA. dantoniucci@psg.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15824846

Citation

Antoniucci, Diana M., et al. "Postmenopausal Bilateral Oophorectomy Is Not Associated With Increased Fracture Risk in Older Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 20, no. 5, 2005, pp. 741-7.
Antoniucci DM, Sellmeyer DE, Cauley JA, et al. Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women. J Bone Miner Res. 2005;20(5):741-7.
Antoniucci, D. M., Sellmeyer, D. E., Cauley, J. A., Ensrud, K. E., Schneider, J. L., Vesco, K. K., ... Melton, L. J. (2005). Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 20(5), pp. 741-7.
Antoniucci DM, et al. Postmenopausal Bilateral Oophorectomy Is Not Associated With Increased Fracture Risk in Older Women. J Bone Miner Res. 2005;20(5):741-7. PubMed PMID: 15824846.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postmenopausal bilateral oophorectomy is not associated with increased fracture risk in older women. AU - Antoniucci,Diana M, AU - Sellmeyer,Deborah E, AU - Cauley,Jane A, AU - Ensrud,Kristine E, AU - Schneider,Jennifer L, AU - Vesco,Kimberly K, AU - Cummings,Steven R, AU - Melton,L Joseph,3rd AU - ,, Y1 - 2004/12/13/ PY - 2004/08/27/received PY - 2004/11/29/revised PY - 2004/12/10/accepted PY - 2005/4/13/pubmed PY - 2005/8/20/medline PY - 2005/4/13/entrez SP - 741 EP - 7 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 20 IS - 5 N2 - UNLABELLED: We studied whether oophorectomy performed after menopause is associated with an increased risk of hip or vertebral fractures in 6295 Study of Osteoporotic Fractures participants. There was no association between postmenopausal oophorectomy and the risk of hip or vertebral fractures. INTRODUCTION: Bilateral oophorectomy after natural menopause has been associated with an increased risk of osteoporotic fractures, potentially because of a decline in serum estradiol and testosterone levels after the oophorectomy. We prospectively tested this hypothesis in the Study of Osteoporotic Fractures (SOF). MATERIALS AND METHODS: We studied 6295 white women 65 years of age participating in the SOF who were not taking estrogen therapy at baseline. Hip fracture analyses included 708 hip fractures; vertebral fracture analyses included 267 incident vertebral fractures. Baseline serum estradiol and free testosterone values were available in a small subset of participants. RESULTS AND CONCLUSION: There were no significant differences in age, weight, or BMD between the women who underwent postmenopausal oophorectomy (n = 583) and those who did not (n = 5712). Free testosterone levels were significantly lower among women who had a postmenopausal oophorectomy. A history of postmenopausal oophorectomy was not associated with an increased risk of hip (hazard ratio [HR] = 1.1; 95% CI = 0.9-1.5) or vertebral fracture (HR = 0.7; 95% CI = 0.5-1.2). The relationship between oophorectomy and hip fracture was not altered by adding serum estradiol level (HR = 1.3; 95% CI = 0.5-3.2) or serum free testosterone level (HR = 1.7; 95% CI = 0.8-3.7) to the model. In summary, postmenopausal oophorectomy was not associated with an increased risk of hip or vertebral fracture in this cohort. These results are in contrast to previous findings, suggesting that the relationship between postmenopausal oophorectomy and fractures is not fully elucidated and that incidental oophorectomy after menopause should still be considered carefully in each potential patient. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/15824846/Postmenopausal_bilateral_oophorectomy_is_not_associated_with_increased_fracture_risk_in_older_women_ L2 - https://doi.org/10.1359/JBMR.041220 DB - PRIME DP - Unbound Medicine ER -