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Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation.
J Agric Food Chem. 2005 Apr 20; 53(8):3223-8.JA

Abstract

The aim of this investigation was to compare the influence of naringin versus red grapefruit juice on plasma lipid levels and plasma antioxidant activity in rats fed cholesterol-containing and cholesterol-free diets. The antioxidant activity of a correlated quantity of red grapefruit juice was higher than that of naringin. Forty-two male Wistar rats were randomly divided into six groups of 7 named control, naringin, grapefruit, Chol, Chol/naringin, and Chol/grapefruit. The rats of the control group were fed basal diet (BD) and 1-2 mL of distilled water. To the BD of the other five groups were added 0.46-0.92 mg of naringin dissolved in 1-2 mL of distilled water (naringin), 1-2 mL of red grapefruit juice (grapefruit), 1% of nonoxidized cholesterol (NOC) and 1-2 mL of distilled water (Chol), 1% of NOC and 0.46-0.92 mg of naringin in 1-2 mL of water (Chol/naringin), and 1% of NOC and 1-2 mL of red grapefruit juice (Chol/grapefruit). After 30 days of different feeding, it was found that diets supplemented with red grapefruit juice and to a lesser degree with naringin improved the plasma lipid levels mainly in rats fed cholesterol and increased the plasma antioxidant activity. In conclusion, naringin is a powerful plasma lipid lowering and plasma antioxidant activity increasing flavonone. However, fresh red grapefruit is preferable than naringin: it more effectively influences plasma lipid levels and plasma antioxidant activity and, therefore, could be used as a valuable supplement for disease-preventing diets.

Authors+Show Affiliations

Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. gorin@cc.huji.ac.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15826081

Citation

Gorinstein, Shela, et al. "Changes in Plasma Lipid and Antioxidant Activity in Rats as a Result of Naringin and Red Grapefruit Supplementation." Journal of Agricultural and Food Chemistry, vol. 53, no. 8, 2005, pp. 3223-8.
Gorinstein S, Leontowicz H, Leontowicz M, et al. Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. J Agric Food Chem. 2005;53(8):3223-8.
Gorinstein, S., Leontowicz, H., Leontowicz, M., Krzeminski, R., Gralak, M., Delgado-Licon, E., Martinez Ayala, A. L., Katrich, E., & Trakhtenberg, S. (2005). Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. Journal of Agricultural and Food Chemistry, 53(8), 3223-8.
Gorinstein S, et al. Changes in Plasma Lipid and Antioxidant Activity in Rats as a Result of Naringin and Red Grapefruit Supplementation. J Agric Food Chem. 2005 Apr 20;53(8):3223-8. PubMed PMID: 15826081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation. AU - Gorinstein,Shela, AU - Leontowicz,Hanna, AU - Leontowicz,Maria, AU - Krzeminski,Ryszard, AU - Gralak,Mikolaj, AU - Delgado-Licon,Efren, AU - Martinez Ayala,Alma Leticia, AU - Katrich,Elena, AU - Trakhtenberg,Simon, PY - 2005/4/14/pubmed PY - 2005/5/27/medline PY - 2005/4/14/entrez SP - 3223 EP - 8 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 53 IS - 8 N2 - The aim of this investigation was to compare the influence of naringin versus red grapefruit juice on plasma lipid levels and plasma antioxidant activity in rats fed cholesterol-containing and cholesterol-free diets. The antioxidant activity of a correlated quantity of red grapefruit juice was higher than that of naringin. Forty-two male Wistar rats were randomly divided into six groups of 7 named control, naringin, grapefruit, Chol, Chol/naringin, and Chol/grapefruit. The rats of the control group were fed basal diet (BD) and 1-2 mL of distilled water. To the BD of the other five groups were added 0.46-0.92 mg of naringin dissolved in 1-2 mL of distilled water (naringin), 1-2 mL of red grapefruit juice (grapefruit), 1% of nonoxidized cholesterol (NOC) and 1-2 mL of distilled water (Chol), 1% of NOC and 0.46-0.92 mg of naringin in 1-2 mL of water (Chol/naringin), and 1% of NOC and 1-2 mL of red grapefruit juice (Chol/grapefruit). After 30 days of different feeding, it was found that diets supplemented with red grapefruit juice and to a lesser degree with naringin improved the plasma lipid levels mainly in rats fed cholesterol and increased the plasma antioxidant activity. In conclusion, naringin is a powerful plasma lipid lowering and plasma antioxidant activity increasing flavonone. However, fresh red grapefruit is preferable than naringin: it more effectively influences plasma lipid levels and plasma antioxidant activity and, therefore, could be used as a valuable supplement for disease-preventing diets. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15826081/Changes_in_plasma_lipid_and_antioxidant_activity_in_rats_as_a_result_of_naringin_and_red_grapefruit_supplementation_ L2 - https://dx.doi.org/10.1021/jf058014h DB - PRIME DP - Unbound Medicine ER -