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Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma.
Obes Surg. 2005 Mar; 15(3):442-6.OS

Abstract

Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis (NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed.

Authors+Show Affiliations

Gastroenterology and Hepatology Unit, University Hospital "Marqués de Valdecilla", Santander, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15826485

Citation

Cuadrado, Antonio, et al. "Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma." Obesity Surgery, vol. 15, no. 3, 2005, pp. 442-6.
Cuadrado A, Orive A, García-Suárez C, et al. Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. Obes Surg. 2005;15(3):442-6.
Cuadrado, A., Orive, A., García-Suárez, C., Domínguez, A., Fernández-Escalante, J. C., Crespo, J., & Pons-Romero, F. (2005). Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. Obesity Surgery, 15(3), 442-6.
Cuadrado A, et al. Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma. Obes Surg. 2005;15(3):442-6. PubMed PMID: 15826485.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. AU - Cuadrado,Antonio, AU - Orive,Aitor, AU - García-Suárez,Covadonga, AU - Domínguez,Agustín, AU - Fernández-Escalante,Jose Carlos, AU - Crespo,Javier, AU - Pons-Romero,Fernando, PY - 2005/4/14/pubmed PY - 2005/7/15/medline PY - 2005/4/14/entrez SP - 442 EP - 6 JF - Obesity surgery JO - Obes Surg VL - 15 IS - 3 N2 - Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis (NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed. SN - 0960-8923 UR - https://www.unboundmedicine.com/medline/citation/15826485/Non_alcoholic_steatohepatitis__NASH__and_hepatocellular_carcinoma_ DB - PRIME DP - Unbound Medicine ER -