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Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry.
J Mass Spectrom. 2005 Jun; 40(6):785-95.JM

Abstract

In recent years, several newer designer drugs of the so-called 2C series such as 2C-D, 2C-E, 2C-P, 2C-B, 2C-I, 2C-T-2, and 2C-T-7 have entered the illicit drug market as recreational drugs. Some fatal intoxications involving 2C-T-7 have been reported. Only scarce data have been published about analyses of these substances in human blood and/or plasma. This paper describes a method for screening and simultaneous quantification of the above-mentioned compounds and their analog mescaline in human blood plasma. The analytes were analyzed by gas chromatography/mass spectrometry in the selected-ion monitoring mode, after mixed-mode solid-phase extraction (HCX) and derivatization with heptafluorobutyric anhydride. The method was fully validated according to international guidelines. Validation data for 2C-T-2 and 2C-T-7 were unacceptable. For all other analytes, the method was linear from 5 to 500 microg/L and the data for accuracy (bias) and precision (coefficient of variation) were within the acceptance limits of +/-15% and <15%, respectively (within +/-20% and <20% near the limit of quantification of 5 microg/L).

Authors+Show Affiliations

Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Saarland, D-66421 Homburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

15827969

Citation

Habrdova, Vilma, et al. "Screening for and Validated Quantification of Phenethylamine-type Designer Drugs and Mescaline in Human Blood Plasma By Gas Chromatography/mass Spectrometry." Journal of Mass Spectrometry : JMS, vol. 40, no. 6, 2005, pp. 785-95.
Habrdova V, Peters FT, Theobald DS, et al. Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry. J Mass Spectrom. 2005;40(6):785-95.
Habrdova, V., Peters, F. T., Theobald, D. S., & Maurer, H. H. (2005). Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry. Journal of Mass Spectrometry : JMS, 40(6), 785-95.
Habrdova V, et al. Screening for and Validated Quantification of Phenethylamine-type Designer Drugs and Mescaline in Human Blood Plasma By Gas Chromatography/mass Spectrometry. J Mass Spectrom. 2005;40(6):785-95. PubMed PMID: 15827969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for and validated quantification of phenethylamine-type designer drugs and mescaline in human blood plasma by gas chromatography/mass spectrometry. AU - Habrdova,Vilma, AU - Peters,Frank T, AU - Theobald,Denis S, AU - Maurer,Hans H, PY - 2005/4/14/pubmed PY - 2005/8/5/medline PY - 2005/4/14/entrez SP - 785 EP - 95 JF - Journal of mass spectrometry : JMS JO - J Mass Spectrom VL - 40 IS - 6 N2 - In recent years, several newer designer drugs of the so-called 2C series such as 2C-D, 2C-E, 2C-P, 2C-B, 2C-I, 2C-T-2, and 2C-T-7 have entered the illicit drug market as recreational drugs. Some fatal intoxications involving 2C-T-7 have been reported. Only scarce data have been published about analyses of these substances in human blood and/or plasma. This paper describes a method for screening and simultaneous quantification of the above-mentioned compounds and their analog mescaline in human blood plasma. The analytes were analyzed by gas chromatography/mass spectrometry in the selected-ion monitoring mode, after mixed-mode solid-phase extraction (HCX) and derivatization with heptafluorobutyric anhydride. The method was fully validated according to international guidelines. Validation data for 2C-T-2 and 2C-T-7 were unacceptable. For all other analytes, the method was linear from 5 to 500 microg/L and the data for accuracy (bias) and precision (coefficient of variation) were within the acceptance limits of +/-15% and <15%, respectively (within +/-20% and <20% near the limit of quantification of 5 microg/L). SN - 1076-5174 UR - https://www.unboundmedicine.com/medline/citation/15827969/Screening_for_and_validated_quantification_of_phenethylamine_type_designer_drugs_and_mescaline_in_human_blood_plasma_by_gas_chromatography/mass_spectrometry_ L2 - https://doi.org/10.1002/jms.853 DB - PRIME DP - Unbound Medicine ER -