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Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c.
Genesis. 2005 May; 42(1):28-32.G

Abstract

Genes expressed in skeletal muscle are often required in other tissues. This is particularly the case for cardiac and smooth muscle, both contractile tissues that share numerous characteristics with skeletal muscle, such that targeted inactivation can lead to embryonic lethality prior to a requirement for gene function in skeletal muscle. Thus, it is essential that conditional inactivation approaches are developed to disrupt genes specifically in skeletal muscle. In this report, we describe a transgenic mouse that expresses Cre recombinase under the control of a skeletal muscle-specific promoter from the mef2c gene. Cre expression in this transgenic line is completely restricted to skeletal muscle from early in development and is present in all skeletal muscles, including those of epaxial and hypaxial origins and in fast and slow fibers. This early skeletal muscle-specific Cre line will be a useful tool to define the function of genes specifically in skeletal muscle.

Authors+Show Affiliations

Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15828002

Citation

Heidt, Analeah B., and Brian L. Black. "Transgenic Mice That Express Cre Recombinase Under Control of a Skeletal Muscle-specific Promoter From Mef2c." Genesis (New York, N.Y. : 2000), vol. 42, no. 1, 2005, pp. 28-32.
Heidt AB, Black BL. Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis. 2005;42(1):28-32.
Heidt, A. B., & Black, B. L. (2005). Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis (New York, N.Y. : 2000), 42(1), 28-32.
Heidt AB, Black BL. Transgenic Mice That Express Cre Recombinase Under Control of a Skeletal Muscle-specific Promoter From Mef2c. Genesis. 2005;42(1):28-32. PubMed PMID: 15828002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. AU - Heidt,Analeah B, AU - Black,Brian L, PY - 2005/4/14/pubmed PY - 2005/8/17/medline PY - 2005/4/14/entrez SP - 28 EP - 32 JF - Genesis (New York, N.Y. : 2000) JO - Genesis VL - 42 IS - 1 N2 - Genes expressed in skeletal muscle are often required in other tissues. This is particularly the case for cardiac and smooth muscle, both contractile tissues that share numerous characteristics with skeletal muscle, such that targeted inactivation can lead to embryonic lethality prior to a requirement for gene function in skeletal muscle. Thus, it is essential that conditional inactivation approaches are developed to disrupt genes specifically in skeletal muscle. In this report, we describe a transgenic mouse that expresses Cre recombinase under the control of a skeletal muscle-specific promoter from the mef2c gene. Cre expression in this transgenic line is completely restricted to skeletal muscle from early in development and is present in all skeletal muscles, including those of epaxial and hypaxial origins and in fast and slow fibers. This early skeletal muscle-specific Cre line will be a useful tool to define the function of genes specifically in skeletal muscle. SN - 1526-954X UR - https://www.unboundmedicine.com/medline/citation/15828002/Transgenic_mice_that_express_Cre_recombinase_under_control_of_a_skeletal_muscle_specific_promoter_from_mef2c_ L2 - https://doi.org/10.1002/gene.20123 DB - PRIME DP - Unbound Medicine ER -