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Is 2.5 mEq/L the optimal calcium concentration of dialysate in the use of sevelamer hydrochloride? A study of the dialysate calcium concentration recommended by K/DOQI guidelines.
Ther Apher Dial. 2005 Feb; 9(1):24-31.TA

Abstract

We tested the effect of three different dialysate calcium concentrations on calcium-phosphorus metabolism during the use of sevelamer hydrochloride. After a calcium-containing phosphate binder was switched to sevelamer, the serum calcium, phosphorus, and intact parathyroid hormone levels and the markers of bone turnover were measured in the patients whose dialysate calcium concentrations were 2.5, 2.75, and 3.0 mEq/L. As a result, in the 2.75-mEq/L group, the serum calcium concentrations decreased and the intact parathyroid hormone level increased significantly. In the 2.5-mEq/L group, transient hypocalcemia occurred and the levels of both bone-alkaline phosphatase and osteocalcin increased. In the 3.0-mEq/L group, the serum calcium concentrations did not change significantly and only bone-alkaline phosphatase increased. If a calcium-containing phosphate binder is completely switched to sevelamer, dialysis using a dialysate calcium concentration below 3.0 mEq/L may result in hypocalcemia and acceleration of bone turnover.

Authors+Show Affiliations

Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo 663-8501, Japan. izumi@hyo-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

15828902

Citation

Izumi, Masaaki, et al. "Is 2.5 mEq/L the Optimal Calcium Concentration of Dialysate in the Use of Sevelamer Hydrochloride? a Study of the Dialysate Calcium Concentration Recommended By K/DOQI Guidelines." Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, vol. 9, no. 1, 2005, pp. 24-31.
Izumi M, Shirai K, Ito K, et al. Is 2.5 mEq/L the optimal calcium concentration of dialysate in the use of sevelamer hydrochloride? A study of the dialysate calcium concentration recommended by K/DOQI guidelines. Ther Apher Dial. 2005;9(1):24-31.
Izumi, M., Shirai, K., Ito, K., Miyamoto, T., Matsumoto, A., Takenaka, Y., Nakagawa, K., Yamanashi, T., Takamitsu, Y., & Nakanish, T. (2005). Is 2.5 mEq/L the optimal calcium concentration of dialysate in the use of sevelamer hydrochloride? A study of the dialysate calcium concentration recommended by K/DOQI guidelines. Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy, 9(1), 24-31.
Izumi M, et al. Is 2.5 mEq/L the Optimal Calcium Concentration of Dialysate in the Use of Sevelamer Hydrochloride? a Study of the Dialysate Calcium Concentration Recommended By K/DOQI Guidelines. Ther Apher Dial. 2005;9(1):24-31. PubMed PMID: 15828902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is 2.5 mEq/L the optimal calcium concentration of dialysate in the use of sevelamer hydrochloride? A study of the dialysate calcium concentration recommended by K/DOQI guidelines. AU - Izumi,Masaaki, AU - Shirai,Kenichi, AU - Ito,Katsukiyo, AU - Miyamoto,Takashi, AU - Matsumoto,Akihide, AU - Takenaka,Yoshiaki, AU - Nakagawa,Kiyohiko, AU - Yamanashi,Toshiaki, AU - Takamitsu,Yoshihiro, AU - Nakanish,Takeshi, PY - 2005/4/15/pubmed PY - 2005/7/23/medline PY - 2005/4/15/entrez SP - 24 EP - 31 JF - Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy JO - Ther Apher Dial VL - 9 IS - 1 N2 - We tested the effect of three different dialysate calcium concentrations on calcium-phosphorus metabolism during the use of sevelamer hydrochloride. After a calcium-containing phosphate binder was switched to sevelamer, the serum calcium, phosphorus, and intact parathyroid hormone levels and the markers of bone turnover were measured in the patients whose dialysate calcium concentrations were 2.5, 2.75, and 3.0 mEq/L. As a result, in the 2.75-mEq/L group, the serum calcium concentrations decreased and the intact parathyroid hormone level increased significantly. In the 2.5-mEq/L group, transient hypocalcemia occurred and the levels of both bone-alkaline phosphatase and osteocalcin increased. In the 3.0-mEq/L group, the serum calcium concentrations did not change significantly and only bone-alkaline phosphatase increased. If a calcium-containing phosphate binder is completely switched to sevelamer, dialysis using a dialysate calcium concentration below 3.0 mEq/L may result in hypocalcemia and acceleration of bone turnover. SN - 1744-9979 UR - https://www.unboundmedicine.com/medline/citation/15828902/Is_2_5_mEq/L_the_optimal_calcium_concentration_of_dialysate_in_the_use_of_sevelamer_hydrochloride_A_study_of_the_dialysate_calcium_concentration_recommended_by_K/DOQI_guidelines_ L2 - https://doi.org/10.1111/j.1774-9987.2005.00210.x DB - PRIME DP - Unbound Medicine ER -