Tags

Type your tag names separated by a space and hit enter

Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat.
Neuropharmacology. 2005 May; 48(6):830-52.N

Abstract

The role of the brain 5-HT1A receptor in cognition was examined in the water maze (WM) and passive avoidance (PA) tasks in the male rat. Pre-training administration of the 5-HT1A receptor agonist 8-OH-DPAT impaired WM performance and facilitated PA retention at low doses (0.01 and 0.03 mg/kg) and impaired PA retention at higher doses (0.1-1.0 mg/kg). The 5-HT1A receptor antagonist NAD-299 produced a dose-dependent facilitation of PA retention. In contrast, the 5-HT1A receptor antagonists NAD-299 and WAY-100635 failed to alter acquisition and retention in the WM. The impairments in WM and PA (but not facilitation in PA) induced by 8-OH-DPAT were blocked by NAD-299. Furthermore, NAD-299 prevented the PA impairments induced by the muscarinic antagonist scopolamine or the NMDA receptor antagonist MK-801. In contrast, NAD-299 and WAY-100635 failed to attenuate the WM impairment induced by scopolamine, probably due to the failure of 5-HT1A receptor blockade to attenuate the sensorimotor disturbances induced by scopolamine. These results indicate that 5-HT1A receptor stimulation and blockade result in opposite effects in two types of cognitive tasks in the rat, and that 5-HT1A receptor blockade can facilitate some aspects of cognitive function, probably via modulation of cholinergic and glutamatergic transmissions. This suggests that 5-HT1A receptor antagonists may have a potential role in the treatment of human degenerative disorders associated with cognitive deficits.

Authors+Show Affiliations

Division of Behavioral Neuroscience, Department of Neuroscience, B3:5, Retzius väg 8, Karolinska Institutet, S-171 77 Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15829255

Citation

Lüttgen, Maria, et al. "Analysis of the Role of 5-HT1A Receptors in Spatial and Aversive Learning in the Rat." Neuropharmacology, vol. 48, no. 6, 2005, pp. 830-52.
Lüttgen M, Elvander E, Madjid N, et al. Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat. Neuropharmacology. 2005;48(6):830-52.
Lüttgen, M., Elvander, E., Madjid, N., & Ogren, S. O. (2005). Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat. Neuropharmacology, 48(6), 830-52.
Lüttgen M, et al. Analysis of the Role of 5-HT1A Receptors in Spatial and Aversive Learning in the Rat. Neuropharmacology. 2005;48(6):830-52. PubMed PMID: 15829255.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of the role of 5-HT1A receptors in spatial and aversive learning in the rat. AU - Lüttgen,Maria, AU - Elvander,Elin, AU - Madjid,Nather, AU - Ogren,Sven Ove, PY - 2004/11/11/received PY - 2004/12/16/revised PY - 2005/01/17/accepted PY - 2005/4/15/pubmed PY - 2005/6/25/medline PY - 2005/4/15/entrez SP - 830 EP - 52 JF - Neuropharmacology JO - Neuropharmacology VL - 48 IS - 6 N2 - The role of the brain 5-HT1A receptor in cognition was examined in the water maze (WM) and passive avoidance (PA) tasks in the male rat. Pre-training administration of the 5-HT1A receptor agonist 8-OH-DPAT impaired WM performance and facilitated PA retention at low doses (0.01 and 0.03 mg/kg) and impaired PA retention at higher doses (0.1-1.0 mg/kg). The 5-HT1A receptor antagonist NAD-299 produced a dose-dependent facilitation of PA retention. In contrast, the 5-HT1A receptor antagonists NAD-299 and WAY-100635 failed to alter acquisition and retention in the WM. The impairments in WM and PA (but not facilitation in PA) induced by 8-OH-DPAT were blocked by NAD-299. Furthermore, NAD-299 prevented the PA impairments induced by the muscarinic antagonist scopolamine or the NMDA receptor antagonist MK-801. In contrast, NAD-299 and WAY-100635 failed to attenuate the WM impairment induced by scopolamine, probably due to the failure of 5-HT1A receptor blockade to attenuate the sensorimotor disturbances induced by scopolamine. These results indicate that 5-HT1A receptor stimulation and blockade result in opposite effects in two types of cognitive tasks in the rat, and that 5-HT1A receptor blockade can facilitate some aspects of cognitive function, probably via modulation of cholinergic and glutamatergic transmissions. This suggests that 5-HT1A receptor antagonists may have a potential role in the treatment of human degenerative disorders associated with cognitive deficits. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/15829255/Analysis_of_the_role_of_5_HT1A_receptors_in_spatial_and_aversive_learning_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(05)00036-5 DB - PRIME DP - Unbound Medicine ER -