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Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn.
J Neurophysiol. 2005 Aug; 94(2):961-7.JN

Abstract

Long-term potentiation (LTP) of C-fiber-evoked field potentials in spinal dorsal horn may be relevant to pathological pain. Our previous work has shown that the late phase of the spinal LTP is protein synthesis-dependent. Considerable evidence has accumulated that dopamine D1/D5 receptors are important for late-phase LTP in hippocampus. In this study, the role of D1/D5 receptors in LTP of C-fiber-evoked field potentials in spinal dorsal horn was evaluated in urethan-anesthetized Sprague-Dawley rats. We found the following. 1) Spinal application of SKF 38393, a D1/D5 receptor agonist, induced a slowly developed LTP of C-fiber-evoked field potentials, lasting for >10 h, and the effect was blocked by the D1/D5 antagonist SCH 23390, whereas a D2 receptor agonist (quinpirole) induced depression of C-fiber responses, lasting for 2 h. 2) The potentiation produced by D1/D5 receptor agonist occluded the late phase but not the early phase of the spinal LTP produced by tetanic stimulation. 3) SCH 23390 selectively depressed the late-phase LTP, when applied 40 min before tetanic stimulation. 4) The D1/D5 agonist-induced potentiation is blocked by the protein synthesis inhibitor anisomycin. 5) Activation of protein kinase A by spinal application of 8-Br-cAMP also induced spinal LTP, and the action occluded the potentiation induced by the D1/D5 receptor agonist. These results suggest that the spinal D1/D5 receptors participate in the protein synthesis-dependent late-phase LTP of C-fiber-evoked field potentials in spinal dorsal horn through the cAMP signaling pathway.

Authors+Show Affiliations

Department of Physiology, Zhongshan Medical School of Sun Yat-sen University, Guangzhou, Peoples Republic of China .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15829590

Citation

Yang, Hong-Wei, et al. "Activation of Spinal D1/d5 Receptors Induces Late-phase LTP of C-fiber-evoked Field Potentials in Rat Spinal Dorsal Horn." Journal of Neurophysiology, vol. 94, no. 2, 2005, pp. 961-7.
Yang HW, Zhou LJ, Hu NW, et al. Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. J Neurophysiol. 2005;94(2):961-7.
Yang, H. W., Zhou, L. J., Hu, N. W., Xin, W. J., & Liu, X. G. (2005). Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. Journal of Neurophysiology, 94(2), 961-7.
Yang HW, et al. Activation of Spinal D1/d5 Receptors Induces Late-phase LTP of C-fiber-evoked Field Potentials in Rat Spinal Dorsal Horn. J Neurophysiol. 2005;94(2):961-7. PubMed PMID: 15829590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activation of spinal d1/d5 receptors induces late-phase LTP of C-fiber-evoked field potentials in rat spinal dorsal horn. AU - Yang,Hong-Wei, AU - Zhou,Li-Jun, AU - Hu,Neng-Wei, AU - Xin,Wen-Jun, AU - Liu,Xian-Guo, Y1 - 2005/04/13/ PY - 2005/4/15/pubmed PY - 2005/9/24/medline PY - 2005/4/15/entrez SP - 961 EP - 7 JF - Journal of neurophysiology JO - J. Neurophysiol. VL - 94 IS - 2 N2 - Long-term potentiation (LTP) of C-fiber-evoked field potentials in spinal dorsal horn may be relevant to pathological pain. Our previous work has shown that the late phase of the spinal LTP is protein synthesis-dependent. Considerable evidence has accumulated that dopamine D1/D5 receptors are important for late-phase LTP in hippocampus. In this study, the role of D1/D5 receptors in LTP of C-fiber-evoked field potentials in spinal dorsal horn was evaluated in urethan-anesthetized Sprague-Dawley rats. We found the following. 1) Spinal application of SKF 38393, a D1/D5 receptor agonist, induced a slowly developed LTP of C-fiber-evoked field potentials, lasting for >10 h, and the effect was blocked by the D1/D5 antagonist SCH 23390, whereas a D2 receptor agonist (quinpirole) induced depression of C-fiber responses, lasting for 2 h. 2) The potentiation produced by D1/D5 receptor agonist occluded the late phase but not the early phase of the spinal LTP produced by tetanic stimulation. 3) SCH 23390 selectively depressed the late-phase LTP, when applied 40 min before tetanic stimulation. 4) The D1/D5 agonist-induced potentiation is blocked by the protein synthesis inhibitor anisomycin. 5) Activation of protein kinase A by spinal application of 8-Br-cAMP also induced spinal LTP, and the action occluded the potentiation induced by the D1/D5 receptor agonist. These results suggest that the spinal D1/D5 receptors participate in the protein synthesis-dependent late-phase LTP of C-fiber-evoked field potentials in spinal dorsal horn through the cAMP signaling pathway. SN - 0022-3077 UR - https://www.unboundmedicine.com/medline/citation/15829590/Activation_of_spinal_d1/d5_receptors_induces_late_phase_LTP_of_C_fiber_evoked_field_potentials_in_rat_spinal_dorsal_horn_ L2 - http://www.physiology.org/doi/full/10.1152/jn.01324.2004?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -