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Recurrent Alcaligenes xylosoxidans keratitis.
Cornea. 2005 May; 24(4):489-90.C

Abstract

PURPOSE

To describe a case of postkeratoplasty recurrent Alcaligenes xylosoxidans keratitis.

METHODS

A 33-year-old man with a history of penetrating keratoplasty developed corneal infiltrate with intact epithelium and then was treated with broad-spectrum antibiotics. Corneal scraping was taken for microbiologic study.

RESULTS

The culture result identified A. xylosoxidans, sensitive to piperacillin and ceftazidime. There were 3 recurrent episodes within 2 months after each apparent resolution achieved after the instillation of topical piperacillin (10 mg/mL). During the fourth attack, the lesion responded poorly to piperacillin and ceftazidime (25 mg/mL), so therapeutic penetrating keratoplasty was performed to eradicate the recalcitrant infection.

CONCLUSIONS

A. xylosoxidans has probably been underreported as a cause of ocular infection. It does not respond to conventional antibiotic therapy and may be difficult to eradicate. Therapeutic penetrating keratoplasty might be necessary if medical treatment fails.

Authors+Show Affiliations

Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15829812

Citation

Huang, Zei-Lun, et al. "Recurrent Alcaligenes Xylosoxidans Keratitis." Cornea, vol. 24, no. 4, 2005, pp. 489-90.
Huang ZL, Chen YF, Chang SW, et al. Recurrent Alcaligenes xylosoxidans keratitis. Cornea. 2005;24(4):489-90.
Huang, Z. L., Chen, Y. F., Chang, S. W., Lin, K. K., & Hsiao, C. H. (2005). Recurrent Alcaligenes xylosoxidans keratitis. Cornea, 24(4), 489-90.
Huang ZL, et al. Recurrent Alcaligenes Xylosoxidans Keratitis. Cornea. 2005;24(4):489-90. PubMed PMID: 15829812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent Alcaligenes xylosoxidans keratitis. AU - Huang,Zei-Lun, AU - Chen,Yeong-Fong, AU - Chang,Shu-Wen, AU - Lin,Ken-Kuo, AU - Hsiao,Ching-Hsi, PY - 2005/4/15/pubmed PY - 2005/7/22/medline PY - 2005/4/15/entrez SP - 489 EP - 90 JF - Cornea JO - Cornea VL - 24 IS - 4 N2 - PURPOSE: To describe a case of postkeratoplasty recurrent Alcaligenes xylosoxidans keratitis. METHODS: A 33-year-old man with a history of penetrating keratoplasty developed corneal infiltrate with intact epithelium and then was treated with broad-spectrum antibiotics. Corneal scraping was taken for microbiologic study. RESULTS: The culture result identified A. xylosoxidans, sensitive to piperacillin and ceftazidime. There were 3 recurrent episodes within 2 months after each apparent resolution achieved after the instillation of topical piperacillin (10 mg/mL). During the fourth attack, the lesion responded poorly to piperacillin and ceftazidime (25 mg/mL), so therapeutic penetrating keratoplasty was performed to eradicate the recalcitrant infection. CONCLUSIONS: A. xylosoxidans has probably been underreported as a cause of ocular infection. It does not respond to conventional antibiotic therapy and may be difficult to eradicate. Therapeutic penetrating keratoplasty might be necessary if medical treatment fails. SN - 0277-3740 UR - https://www.unboundmedicine.com/medline/citation/15829812/Recurrent_Alcaligenes_xylosoxidans_keratitis_ L2 - https://doi.org/10.1097/01.ico.0000151562.17366.77 DB - PRIME DP - Unbound Medicine ER -