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Swimming exercise training prior to acute myocardial infarction attenuates left ventricular remodeling and improves left ventricular function in rats.
Ann Clin Lab Sci. 2005 Winter; 35(1):73-8.AC

Abstract

The effect of exercise training prior to acute myocardial infarction (AMI) on left ventricular (LV) remodeling is poorly understood. This study investigated the protective effect of 3 weeks of swimming exercise training prior to AMI on cardiac morphology and function. Male Sprague-Dawley rats (n = 35) were randomly assigned to 3 groups: swimming training (n = 14, 90 min, 5 days/wk, 3 wk), sedentary (n =14), and controls (n = 7, no exercise, no MI). At the end of the training/sedentary period, rats were subjected to AMI (ExMI and SedMI) induced by surgical ligation of the left coronary artery. Thereafter, the rats remained sedentary for a 4-wk recovery period. Trans-thoracic echocardiography was performed in each group at the end of the exercise/sedentary period (pre-AMI), 24 hr after AMI, and following recovery (4 wk after AMI). No differences were observed in LV dimensions and function pre-AMI among the 3 groups; however, LV-end systolic diameter (LVESD) and LV-end systolic area (LVES-area) were significantly lower in the prior trained rats, 24 hr post-AMI with no additional change 4 wk post-AMI, during remodeling. Both LV-shortening fraction (SF%) and fractional area change (FAC%) were higher in the trained animals 4 wk post-AMI (39+/-12% vs 23+/-8%; p 0.002, and 48+/-14% vs. 38+/-9%; p 0.07, respectively). In conclusion, 3 wk of swimming exercise training prior to AMI significantly attenuated LV remodeling and improved LV function, despite no changes in LV dimensions or systolic function at the end of the exercise session. The data suggest that even a short-term training period is sufficient to induce cardiac protection.

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Authors+Show Affiliations

Dayan A
Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer, Israel.
Feinberg MS
No affiliation info available
Holbova R
No affiliation info available
Deshet N
No affiliation info available
Scheinowitz M
No affiliation info available

MeSH

Acute DiseaseAnimalsBody WeightDisease Models, AnimalHeartLife StyleMaleMyocardial InfarctionOrgan SizePhysical Conditioning, AnimalRatsRats, Sprague-DawleySwimmingVentricular Function, LeftVentricular Remodeling

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15830712

Citation

Dayan, Anat, et al. "Swimming Exercise Training Prior to Acute Myocardial Infarction Attenuates Left Ventricular Remodeling and Improves Left Ventricular Function in Rats." Annals of Clinical and Laboratory Science, vol. 35, no. 1, 2005, pp. 73-8.
Dayan A, Feinberg MS, Holbova R, et al. Swimming exercise training prior to acute myocardial infarction attenuates left ventricular remodeling and improves left ventricular function in rats. Ann Clin Lab Sci. 2005;35(1):73-8.
Dayan, A., Feinberg, M. S., Holbova, R., Deshet, N., & Scheinowitz, M. (2005). Swimming exercise training prior to acute myocardial infarction attenuates left ventricular remodeling and improves left ventricular function in rats. Annals of Clinical and Laboratory Science, 35(1), 73-8.
Dayan A, et al. Swimming Exercise Training Prior to Acute Myocardial Infarction Attenuates Left Ventricular Remodeling and Improves Left Ventricular Function in Rats. Ann Clin Lab Sci. 2005;35(1):73-8. PubMed PMID: 15830712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Swimming exercise training prior to acute myocardial infarction attenuates left ventricular remodeling and improves left ventricular function in rats. AU - Dayan,Anat, AU - Feinberg,Micha S, AU - Holbova,Radka, AU - Deshet,Naamit, AU - Scheinowitz,Mickey, PY - 2005/4/16/pubmed PY - 2005/8/11/medline PY - 2005/4/16/entrez SP - 73 EP - 8 JF - Annals of clinical and laboratory science JO - Ann Clin Lab Sci VL - 35 IS - 1 N2 - The effect of exercise training prior to acute myocardial infarction (AMI) on left ventricular (LV) remodeling is poorly understood. This study investigated the protective effect of 3 weeks of swimming exercise training prior to AMI on cardiac morphology and function. Male Sprague-Dawley rats (n = 35) were randomly assigned to 3 groups: swimming training (n = 14, 90 min, 5 days/wk, 3 wk), sedentary (n =14), and controls (n = 7, no exercise, no MI). At the end of the training/sedentary period, rats were subjected to AMI (ExMI and SedMI) induced by surgical ligation of the left coronary artery. Thereafter, the rats remained sedentary for a 4-wk recovery period. Trans-thoracic echocardiography was performed in each group at the end of the exercise/sedentary period (pre-AMI), 24 hr after AMI, and following recovery (4 wk after AMI). No differences were observed in LV dimensions and function pre-AMI among the 3 groups; however, LV-end systolic diameter (LVESD) and LV-end systolic area (LVES-area) were significantly lower in the prior trained rats, 24 hr post-AMI with no additional change 4 wk post-AMI, during remodeling. Both LV-shortening fraction (SF%) and fractional area change (FAC%) were higher in the trained animals 4 wk post-AMI (39+/-12% vs 23+/-8%; p 0.002, and 48+/-14% vs. 38+/-9%; p 0.07, respectively). In conclusion, 3 wk of swimming exercise training prior to AMI significantly attenuated LV remodeling and improved LV function, despite no changes in LV dimensions or systolic function at the end of the exercise session. The data suggest that even a short-term training period is sufficient to induce cardiac protection. SN - 0091-7370 UR - https://www.unboundmedicine.com/medline/citation/15830712/Swimming_exercise_training_prior_to_acute_myocardial_infarction_attenuates_left_ventricular_remodeling_and_improves_left_ventricular_function_in_rats_ L2 - http://www.annclinlabsci.org/cgi/pmidlookup?view=long&pmid=15830712 DB - PRIME DP - Unbound Medicine ER -