Tags

Type your tag names separated by a space and hit enter

Effect of increase of dietary micronutrient intake on oxidative stress indicators in HIV/AIDS patients.
Int J Vitam Nutr Res 2005; 75(1):19-27IJ

Abstract

Several recent studies in human immunodeficiency virus (HIV) patients have identified micronutrient deficiencies as affecting progression to acquired immunodeficiency syndrome (AIDS) and death. Although the mechanisms are not known, micronutrient deficiencies may exacerbate the oxidative stress induced by HIV. In addition, infection and its evolution likely lead to an increased requirement for nutritional micronutrients, especially antioxidants. To evaluate this, 40 relatively healthy, institutionalized HIV-infected individuals were recruited for assessment before or three months after fresh fruit and vegetable supply were increased due to seasonal supply. Seven-day dietary records were recorded at the beginning (December) and end of the three-month study period (March). Oxidative stress indices and CD4+, CD38+/CD8+, and CD95+ T-lymphocyte subsets were also measured at these times. No significant differences were found in calorie or protein intake across the study period, but vitamin A, C, and E intakes all increased. A number of redox indicators were modified (increase: total antioxidant status, glutathione peroxidase, and glutathione; and decrease: superoxide dismutase) during the study period. However, no change in malondialdehyde, hydroperoxides, or DNA damage was noted but a significant reduction in CD38+/CD8+ relative count was seen. Within the context and limitations of this study, the increase of dietary fruits and vegetables intake for three months had some beneficial effects on nutrition, systemic redox balance, and immune parameters in HIV-infected persons.

Authors+Show Affiliations

Department of Clinical Pharmacology, Hospital, Institute "Pedro Kouri", Havana, Cuba. lgil@ipk.sld.cuNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15830917

Citation

Gil, Lizette, et al. "Effect of Increase of Dietary Micronutrient Intake On Oxidative Stress Indicators in HIV/AIDS Patients." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 75, no. 1, 2005, pp. 19-27.
Gil L, Lewis L, Martínez G, et al. Effect of increase of dietary micronutrient intake on oxidative stress indicators in HIV/AIDS patients. Int J Vitam Nutr Res. 2005;75(1):19-27.
Gil, L., Lewis, L., Martínez, G., Tarinas, A., González, I., Alvarez, A., ... Pérez, J. (2005). Effect of increase of dietary micronutrient intake on oxidative stress indicators in HIV/AIDS patients. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 75(1), pp. 19-27.
Gil L, et al. Effect of Increase of Dietary Micronutrient Intake On Oxidative Stress Indicators in HIV/AIDS Patients. Int J Vitam Nutr Res. 2005;75(1):19-27. PubMed PMID: 15830917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of increase of dietary micronutrient intake on oxidative stress indicators in HIV/AIDS patients. AU - Gil,Lizette, AU - Lewis,Lidianys, AU - Martínez,Gregorio, AU - Tarinas,Alicia, AU - González,Ivón, AU - Alvarez,Alejandro, AU - Tápanes,Rolando, AU - Giuliani,Attilia, AU - León,Olga Sonia, AU - Pérez,Jorge, PY - 2005/4/16/pubmed PY - 2005/9/9/medline PY - 2005/4/16/entrez SP - 19 EP - 27 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 75 IS - 1 N2 - Several recent studies in human immunodeficiency virus (HIV) patients have identified micronutrient deficiencies as affecting progression to acquired immunodeficiency syndrome (AIDS) and death. Although the mechanisms are not known, micronutrient deficiencies may exacerbate the oxidative stress induced by HIV. In addition, infection and its evolution likely lead to an increased requirement for nutritional micronutrients, especially antioxidants. To evaluate this, 40 relatively healthy, institutionalized HIV-infected individuals were recruited for assessment before or three months after fresh fruit and vegetable supply were increased due to seasonal supply. Seven-day dietary records were recorded at the beginning (December) and end of the three-month study period (March). Oxidative stress indices and CD4+, CD38+/CD8+, and CD95+ T-lymphocyte subsets were also measured at these times. No significant differences were found in calorie or protein intake across the study period, but vitamin A, C, and E intakes all increased. A number of redox indicators were modified (increase: total antioxidant status, glutathione peroxidase, and glutathione; and decrease: superoxide dismutase) during the study period. However, no change in malondialdehyde, hydroperoxides, or DNA damage was noted but a significant reduction in CD38+/CD8+ relative count was seen. Within the context and limitations of this study, the increase of dietary fruits and vegetables intake for three months had some beneficial effects on nutrition, systemic redox balance, and immune parameters in HIV-infected persons. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/15830917/full_citation L2 - http://econtent.hogrefe.com/doi/full/10.1024/0300-9831.75.1.19?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -