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Analysis of gamma-hydroxybutyric acid (GHB) in spiked water and beverage samples using solid phase microextraction (SPME) on fiber derivatization/gas chromatography-mass spectrometry (GC/MS).
J Forensic Sci. 2005 Jan; 50(1):31-6.JF

Abstract

Gamma-Hydroxybutyric acid (GHB) is a CNS depressant that has been abused recreationally for its purported euphoric and relaxation effects and for the purposes of drug facilitated sexual assault due to its sedative and amnesic effects at higher doses. The dramatic increase in the abuse of GHB and association in criminal investigations over the past decade has created the need for forensic laboratories to develop analytical methods to detect GHB in a variety of matrices. The method developed in this work used solid-phase microextraction (SPME) to extract GHB from aqueous samples followed by on-fiber derivatization and analysis by gas chromatography/mass spectrometry (GC/MS). This method detected GHB in aqueous matrices with good sensitivity, high precision, excellent linearity from 0.01 mg/mL to 0.25 mg/mL, and without the need for sample manipulation that could cause interconversion between GHB and its lactone, GBL. The method was successfully applied for detection of GHB in spiked water and beverage samples.

Authors+Show Affiliations

International Forensic Research Institute, Department of Chemistry, Florida International University, University Park, Miami, FL 33199, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15830994

Citation

Meyers, Jodi E., and José R. Almirall. "Analysis of Gamma-hydroxybutyric Acid (GHB) in Spiked Water and Beverage Samples Using Solid Phase Microextraction (SPME) On Fiber Derivatization/gas Chromatography-mass Spectrometry (GC/MS)." Journal of Forensic Sciences, vol. 50, no. 1, 2005, pp. 31-6.
Meyers JE, Almirall JR. Analysis of gamma-hydroxybutyric acid (GHB) in spiked water and beverage samples using solid phase microextraction (SPME) on fiber derivatization/gas chromatography-mass spectrometry (GC/MS). J Forensic Sci. 2005;50(1):31-6.
Meyers, J. E., & Almirall, J. R. (2005). Analysis of gamma-hydroxybutyric acid (GHB) in spiked water and beverage samples using solid phase microextraction (SPME) on fiber derivatization/gas chromatography-mass spectrometry (GC/MS). Journal of Forensic Sciences, 50(1), 31-6.
Meyers JE, Almirall JR. Analysis of Gamma-hydroxybutyric Acid (GHB) in Spiked Water and Beverage Samples Using Solid Phase Microextraction (SPME) On Fiber Derivatization/gas Chromatography-mass Spectrometry (GC/MS). J Forensic Sci. 2005;50(1):31-6. PubMed PMID: 15830994.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of gamma-hydroxybutyric acid (GHB) in spiked water and beverage samples using solid phase microextraction (SPME) on fiber derivatization/gas chromatography-mass spectrometry (GC/MS). AU - Meyers,Jodi E, AU - Almirall,José R, PY - 2005/4/16/pubmed PY - 2005/5/6/medline PY - 2005/4/16/entrez SP - 31 EP - 6 JF - Journal of forensic sciences JO - J Forensic Sci VL - 50 IS - 1 N2 - Gamma-Hydroxybutyric acid (GHB) is a CNS depressant that has been abused recreationally for its purported euphoric and relaxation effects and for the purposes of drug facilitated sexual assault due to its sedative and amnesic effects at higher doses. The dramatic increase in the abuse of GHB and association in criminal investigations over the past decade has created the need for forensic laboratories to develop analytical methods to detect GHB in a variety of matrices. The method developed in this work used solid-phase microextraction (SPME) to extract GHB from aqueous samples followed by on-fiber derivatization and analysis by gas chromatography/mass spectrometry (GC/MS). This method detected GHB in aqueous matrices with good sensitivity, high precision, excellent linearity from 0.01 mg/mL to 0.25 mg/mL, and without the need for sample manipulation that could cause interconversion between GHB and its lactone, GBL. The method was successfully applied for detection of GHB in spiked water and beverage samples. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/15830994/Analysis_of_gamma_hydroxybutyric_acid__GHB__in_spiked_water_and_beverage_samples_using_solid_phase_microextraction__SPME__on_fiber_derivatization/gas_chromatography_mass_spectrometry__GC/MS__ DB - PRIME DP - Unbound Medicine ER -