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Short-term effects of 308-nm xenon-chloride excimer laser and narrow-band ultraviolet B in the treatment of vitiligo: a comparative study.
J Korean Med Sci. 2005 Apr; 20(2):273-8.JK

Abstract

We compared the clinical efficacy of a short-term intervention of 308-nm excimer laser with that of narrow-band UVB (NBUVB) phototherapy for vitiligo patients to see the early response. Twenty-three symmetrically patterned patches of vitiligo on 8 patients were selected. Vitiligo patches on one side of the body were treated 2 times per week for a maximum of 20 treatments with the excimer laser, and NBUVB phototherapy was used on patches on the other side. Improvement (repigmentation) was assessed on a visual scale via serial photographs taken every five treatments and scored as follows: 0,< or =1% improvement; 1,< or =25% improvement; 2, 26-50% improvement; 3, 51-75% improvement; and 4, > or =75% improvement. At five treatments, the excimer laser-treated patches had an average score of 0.26, compared with 0.04 for patches treated with NBUVB phototherapy. A slightly higher repigmentation (p>0.05) in the excimer treated area was thus observed. At 10, 15, or 20 treatments, the differences between the average scores were significant: 0.83, 1.17, and 1.39 for the excimer-treated patches, and 0.17, 0.30, and 0.74 for the NBUVB phototherapy-treated areas (p<0.05). In conclusion, the 308-nm excimer laser appears to be more effective than NBUVB phototherapy, as it produces more rapid and profound repigmentation.

Authors+Show Affiliations

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul 130-702, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15832000

Citation

Hong, Seok-Beom, et al. "Short-term Effects of 308-nm Xenon-chloride Excimer Laser and Narrow-band Ultraviolet B in the Treatment of Vitiligo: a Comparative Study." Journal of Korean Medical Science, vol. 20, no. 2, 2005, pp. 273-8.
Hong SB, Park HH, Lee MH. Short-term effects of 308-nm xenon-chloride excimer laser and narrow-band ultraviolet B in the treatment of vitiligo: a comparative study. J Korean Med Sci. 2005;20(2):273-8.
Hong, S. B., Park, H. H., & Lee, M. H. (2005). Short-term effects of 308-nm xenon-chloride excimer laser and narrow-band ultraviolet B in the treatment of vitiligo: a comparative study. Journal of Korean Medical Science, 20(2), 273-8.
Hong SB, Park HH, Lee MH. Short-term Effects of 308-nm Xenon-chloride Excimer Laser and Narrow-band Ultraviolet B in the Treatment of Vitiligo: a Comparative Study. J Korean Med Sci. 2005;20(2):273-8. PubMed PMID: 15832000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of 308-nm xenon-chloride excimer laser and narrow-band ultraviolet B in the treatment of vitiligo: a comparative study. AU - Hong,Seok-Beom, AU - Park,Hyun-Ho, AU - Lee,Mu-Hyoung, PY - 2005/4/16/pubmed PY - 2005/7/15/medline PY - 2005/4/16/entrez SP - 273 EP - 8 JF - Journal of Korean medical science JO - J. Korean Med. Sci. VL - 20 IS - 2 N2 - We compared the clinical efficacy of a short-term intervention of 308-nm excimer laser with that of narrow-band UVB (NBUVB) phototherapy for vitiligo patients to see the early response. Twenty-three symmetrically patterned patches of vitiligo on 8 patients were selected. Vitiligo patches on one side of the body were treated 2 times per week for a maximum of 20 treatments with the excimer laser, and NBUVB phototherapy was used on patches on the other side. Improvement (repigmentation) was assessed on a visual scale via serial photographs taken every five treatments and scored as follows: 0,< or =1% improvement; 1,< or =25% improvement; 2, 26-50% improvement; 3, 51-75% improvement; and 4, > or =75% improvement. At five treatments, the excimer laser-treated patches had an average score of 0.26, compared with 0.04 for patches treated with NBUVB phototherapy. A slightly higher repigmentation (p>0.05) in the excimer treated area was thus observed. At 10, 15, or 20 treatments, the differences between the average scores were significant: 0.83, 1.17, and 1.39 for the excimer-treated patches, and 0.17, 0.30, and 0.74 for the NBUVB phototherapy-treated areas (p<0.05). In conclusion, the 308-nm excimer laser appears to be more effective than NBUVB phototherapy, as it produces more rapid and profound repigmentation. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/15832000/Short_term_effects_of_308_nm_xenon_chloride_excimer_laser_and_narrow_band_ultraviolet_B_in_the_treatment_of_vitiligo:_a_comparative_study_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2005.20.2.273 DB - PRIME DP - Unbound Medicine ER -