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Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test.
J Korean Med Sci. 2005 Apr; 20(2):307-12.JK

Abstract

Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting acute nociception. The authors evaluated the effects of intrathecal gabapentin, NMDA antagonist (MK801) and AMPA antagonist (NBQX) in the formalin test which shows injury-induced hyperalgesia as well as acute pain. We further assessed the interactions between gabapentin and either MK801 or NBQX. Male Sprague-Dawley rats were implanted with intrathecal catheters. To evoke pain, 50 microL of 5% formalin solution was injected into the hindpaw. The interaction was investigated by a fixed dose analysis or an isobolographic analysis. MK801 and NBQX suppressed flinching responses during phase 1 of the formalin test, while gabapentin had little effect on phase 1. All three agents decreased the phase 2 flinching response. A fixed dose analysis in phase 1 showed that gabapentin potentiated the antinociceptive effect of MK801 and NBQX. Isobolographic analysis in phase 2 revealed a synergistic interaction after coadministration of gabapentin-MK801 or gabapentin-NBQX. Correspondingly, spinal gabapentin with NMDA or AMPA antagonist may be useful in managing acute pain and injury-induced hyperalgesia.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Chonnam National University, Medical School, Gwangju 501-757, Korea. mhyoon@chonnam.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15832006

Citation

Yoon, Myung Ha, et al. "Antinociceptive Interactions Between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test." Journal of Korean Medical Science, vol. 20, no. 2, 2005, pp. 307-12.
Yoon MH, Bae HB, Choi JI. Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. J Korean Med Sci. 2005;20(2):307-12.
Yoon, M. H., Bae, H. B., & Choi, J. I. (2005). Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. Journal of Korean Medical Science, 20(2), 307-12.
Yoon MH, Bae HB, Choi JI. Antinociceptive Interactions Between Intrathecal Gabapentin and MK801 or NBQX in Rat Formalin Test. J Korean Med Sci. 2005;20(2):307-12. PubMed PMID: 15832006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. AU - Yoon,Myung Ha, AU - Bae,Hong Beom, AU - Choi,Jeong Il, PY - 2005/4/16/pubmed PY - 2005/7/15/medline PY - 2005/4/16/entrez SP - 307 EP - 12 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 20 IS - 2 N2 - Antagonists for spinal N-methyl-D-aspartate (NMDA) and amino-hydroxy-methtyl-isoxazolepropionate (AMPA) receptors are effective in attenuating acute nociception or injury-induced hyperalgesia. The antinociception of spinal gabapentin is developed in injury-induced hyperalgesia without affecting acute nociception. The authors evaluated the effects of intrathecal gabapentin, NMDA antagonist (MK801) and AMPA antagonist (NBQX) in the formalin test which shows injury-induced hyperalgesia as well as acute pain. We further assessed the interactions between gabapentin and either MK801 or NBQX. Male Sprague-Dawley rats were implanted with intrathecal catheters. To evoke pain, 50 microL of 5% formalin solution was injected into the hindpaw. The interaction was investigated by a fixed dose analysis or an isobolographic analysis. MK801 and NBQX suppressed flinching responses during phase 1 of the formalin test, while gabapentin had little effect on phase 1. All three agents decreased the phase 2 flinching response. A fixed dose analysis in phase 1 showed that gabapentin potentiated the antinociceptive effect of MK801 and NBQX. Isobolographic analysis in phase 2 revealed a synergistic interaction after coadministration of gabapentin-MK801 or gabapentin-NBQX. Correspondingly, spinal gabapentin with NMDA or AMPA antagonist may be useful in managing acute pain and injury-induced hyperalgesia. SN - 1011-8934 UR - https://www.unboundmedicine.com/medline/citation/15832006/Antinociceptive_interactions_between_intrathecal_gabapentin_and_MK801_or_NBQX_in_rat_formalin_test_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2005.20.2.307 DB - PRIME DP - Unbound Medicine ER -