Tags

Type your tag names separated by a space and hit enter

Calcium loading, calcium accumulation, and associated cardiovascular risks in dialysis patients.
Blood Purif 2005; 23 Suppl 1:12-9BP

Abstract

Calcium and phosphate imbalances are important mutable risk factors for cardiovascular disease in chronic kidney disease (CKD). Nearly all dialysis patients require phosphate binders. These include traditional calcium-based compounds and, more recently, the calcium-free, metal-free, non-absorbed agent, sevelamer hydrochloride. Both binder types reduce serum phosphorus, but differ with respect to calcium load and metabolism. Absorption from calcium-based agents very likely promotes positive total calcium balance in many patients. Positive calcium balance is inappropriate in adults and may promote or accelerate soft-tissue and vascular calcification even in the absence of hypercalcemia. Calcium accumulation in heart and vascular tissues contributes to rapidly progressive cardiovascular calcification - a strong predictor of cardiovascular and all-cause mortality in stage 5 CKD. More than two-thirds of stage 5 CKD patients have calcification scores above the 75th percentile for matched controls -- scores associated with extremely high risk of cardiovascular events and death.

Authors+Show Affiliations

University North Carolina, Division of Nephrology and Hypertension, Chapel Hill, NC 27514, USA. philip_klemmer@med.unc.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15832018

Citation

Klemmer, Philip J.. "Calcium Loading, Calcium Accumulation, and Associated Cardiovascular Risks in Dialysis Patients." Blood Purification, vol. 23 Suppl 1, 2005, pp. 12-9.
Klemmer PJ. Calcium loading, calcium accumulation, and associated cardiovascular risks in dialysis patients. Blood Purif. 2005;23 Suppl 1:12-9.
Klemmer, P. J. (2005). Calcium loading, calcium accumulation, and associated cardiovascular risks in dialysis patients. Blood Purification, 23 Suppl 1, pp. 12-9.
Klemmer PJ. Calcium Loading, Calcium Accumulation, and Associated Cardiovascular Risks in Dialysis Patients. Blood Purif. 2005;23 Suppl 1:12-9. PubMed PMID: 15832018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium loading, calcium accumulation, and associated cardiovascular risks in dialysis patients. A1 - Klemmer,Philip J, PY - 2005/4/16/pubmed PY - 2005/7/1/medline PY - 2005/4/16/entrez SP - 12 EP - 9 JF - Blood purification JO - Blood Purif. VL - 23 Suppl 1 N2 - Calcium and phosphate imbalances are important mutable risk factors for cardiovascular disease in chronic kidney disease (CKD). Nearly all dialysis patients require phosphate binders. These include traditional calcium-based compounds and, more recently, the calcium-free, metal-free, non-absorbed agent, sevelamer hydrochloride. Both binder types reduce serum phosphorus, but differ with respect to calcium load and metabolism. Absorption from calcium-based agents very likely promotes positive total calcium balance in many patients. Positive calcium balance is inappropriate in adults and may promote or accelerate soft-tissue and vascular calcification even in the absence of hypercalcemia. Calcium accumulation in heart and vascular tissues contributes to rapidly progressive cardiovascular calcification - a strong predictor of cardiovascular and all-cause mortality in stage 5 CKD. More than two-thirds of stage 5 CKD patients have calcification scores above the 75th percentile for matched controls -- scores associated with extremely high risk of cardiovascular events and death. SN - 0253-5068 UR - https://www.unboundmedicine.com/medline/citation/15832018/full_citation L2 - https://www.karger.com?DOI=10.1159/000083713 DB - PRIME DP - Unbound Medicine ER -