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Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma.
J Allergy Clin Immunol. 1992 May; 89(5):1040-5.JA

Abstract

We studied the effect of a single oral dose of ICI 204,219 on subject response to bronchoprovocation and quantitative skin testing with standardized allergen (cat dander). Cat-allergic male subjects with asthma entered the double-blind, randomized, placebo-controlled, crossover study. Each subject received a 40 mg dose of ICI 204,219 or placebo on study days separated by at least 10 days. After dosing, each subject underwent bronchoprovocation with cat allergen until a provocative dose of allergen caused a 20% decrease in FEV1 or a maximum dose of 30,000 AU/ml was reached. Fifteen subjects entered and 13 completed the study. No significant shift in the dose-response curve of the quantitative skin test occurred in any subject. A mean tenfold increase in the interpolated provocative concentration causing a 20% decrease in FEV1 was observed between ICI 204,219 (6996 +/- 3204 AU/ml) and placebo (460 +/- 98 AU/ml). Eight of 12 subjects required more antigen to provoke a bronchoprovocation response after dosing with ICI 204,219 than that required with placebo (range, threefold to 30-fold), three demonstrated no difference (less than twofold), and one subject required less antigen after ICI 204,219 (sevenfold less). Area under the curve measurements were significantly different (p less than 0.05) between ICI 204,219 and placebo for the fixed time from the end point of the allergen bronchoprovocation to 5 hours after provocation. In conclusion, this trial demonstrates that a single oral dose of ICI 204,219 antagonizes the bronchoconstriction induced by inhaled cat allergen.

Authors+Show Affiliations

HealthQuest Research, Austin, TX 78731.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1583246

Citation

Findlay, S R., et al. "Effect of the Oral Leukotriene Antagonist, ICI 204,219, On Antigen-induced Bronchoconstriction in Subjects With Asthma." The Journal of Allergy and Clinical Immunology, vol. 89, no. 5, 1992, pp. 1040-5.
Findlay SR, Barden JM, Easley CB, et al. Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma. J Allergy Clin Immunol. 1992;89(5):1040-5.
Findlay, S. R., Barden, J. M., Easley, C. B., & Glass, M. (1992). Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma. The Journal of Allergy and Clinical Immunology, 89(5), 1040-5.
Findlay SR, et al. Effect of the Oral Leukotriene Antagonist, ICI 204,219, On Antigen-induced Bronchoconstriction in Subjects With Asthma. J Allergy Clin Immunol. 1992;89(5):1040-5. PubMed PMID: 1583246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the oral leukotriene antagonist, ICI 204,219, on antigen-induced bronchoconstriction in subjects with asthma. AU - Findlay,S R, AU - Barden,J M, AU - Easley,C B, AU - Glass,M, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 1040 EP - 5 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 89 IS - 5 N2 - We studied the effect of a single oral dose of ICI 204,219 on subject response to bronchoprovocation and quantitative skin testing with standardized allergen (cat dander). Cat-allergic male subjects with asthma entered the double-blind, randomized, placebo-controlled, crossover study. Each subject received a 40 mg dose of ICI 204,219 or placebo on study days separated by at least 10 days. After dosing, each subject underwent bronchoprovocation with cat allergen until a provocative dose of allergen caused a 20% decrease in FEV1 or a maximum dose of 30,000 AU/ml was reached. Fifteen subjects entered and 13 completed the study. No significant shift in the dose-response curve of the quantitative skin test occurred in any subject. A mean tenfold increase in the interpolated provocative concentration causing a 20% decrease in FEV1 was observed between ICI 204,219 (6996 +/- 3204 AU/ml) and placebo (460 +/- 98 AU/ml). Eight of 12 subjects required more antigen to provoke a bronchoprovocation response after dosing with ICI 204,219 than that required with placebo (range, threefold to 30-fold), three demonstrated no difference (less than twofold), and one subject required less antigen after ICI 204,219 (sevenfold less). Area under the curve measurements were significantly different (p less than 0.05) between ICI 204,219 and placebo for the fixed time from the end point of the allergen bronchoprovocation to 5 hours after provocation. In conclusion, this trial demonstrates that a single oral dose of ICI 204,219 antagonizes the bronchoconstriction induced by inhaled cat allergen. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/1583246/Effect_of_the_oral_leukotriene_antagonist_ICI_204219_on_antigen_induced_bronchoconstriction_in_subjects_with_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(92)90227-S DB - PRIME DP - Unbound Medicine ER -