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Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet.
Obes Res. 2005 Mar; 13(3):556-66.OR

Abstract

OBJECTIVE

Mice divergently selected for high or low food intake (FI) at constant body mass differ in their resting metabolic rates (RMRs). Low-intake individuals (ML) have significantly lower RMR (by 30%) compared with those from the high-intake line (MH). We hypothesized that MLs might, therefore, be more likely to increase their body and fat mass when exposed to a high-fat diet (HFD).

RESEARCH METHODS AND PROCEDURES

We exposed both lines to a diet with 44.9% calories from fat for 3 weeks while measuring FI, fecal production, and body mass and then returned the mice to standard chow.

RESULTS

When exposed to the HFD, both lines significantly decreased their FI (MH, 40% to 45%; ML, 31% to 35%). This decrease occurred simultaneously with a significant increase in apparent energy absorption efficiency (AEAE). When returned to chow, FI and AEAE returned to the levels observed prior to HFD exposure. Because of the adjustments in FI, the absorbed energy was maintained in the MLs and, thus, body mass remained constant. The MH individuals overcompensated for the elevated energy content and AEAE on the HFD and, therefore, absorbed lower energy than when feeding on chow. These mice also did not significantly change their body mass when on the HFD and must have made adjustments in their energy expenditures. Both lines and both sexes increased in fat content on the HFD, but these effects were not different between lines or sexes.

DISCUSSION

We found no support for the hypothesis that mice with low RMRs were more susceptible to weight gain when fed the HFD.

Authors+Show Affiliations

School of Biological Sciences, Aberdeen Center for Energy Regulation and Obesity, University of Aberdeen, Aberdeen, UK. c.hambly@rowett.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15833941

Citation

Hambly, Catherine, et al. "Mice With Low Metabolic Rates Are Not Susceptible to Weight Gain when Fed a High-fat Diet." Obesity Research, vol. 13, no. 3, 2005, pp. 556-66.
Hambly C, Adams A, Fustin JM, et al. Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet. Obes Res. 2005;13(3):556-66.
Hambly, C., Adams, A., Fustin, J. M., Rance, K. A., Bünger, L., & Speakman, J. R. (2005). Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet. Obesity Research, 13(3), 556-66.
Hambly C, et al. Mice With Low Metabolic Rates Are Not Susceptible to Weight Gain when Fed a High-fat Diet. Obes Res. 2005;13(3):556-66. PubMed PMID: 15833941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet. AU - Hambly,Catherine, AU - Adams,Andrew, AU - Fustin,Jean-Michel, AU - Rance,Kellie A, AU - Bünger,Lutz, AU - Speakman,John R, PY - 2005/4/19/pubmed PY - 2005/8/3/medline PY - 2005/4/19/entrez SP - 556 EP - 66 JF - Obesity research JO - Obes. Res. VL - 13 IS - 3 N2 - OBJECTIVE: Mice divergently selected for high or low food intake (FI) at constant body mass differ in their resting metabolic rates (RMRs). Low-intake individuals (ML) have significantly lower RMR (by 30%) compared with those from the high-intake line (MH). We hypothesized that MLs might, therefore, be more likely to increase their body and fat mass when exposed to a high-fat diet (HFD). RESEARCH METHODS AND PROCEDURES: We exposed both lines to a diet with 44.9% calories from fat for 3 weeks while measuring FI, fecal production, and body mass and then returned the mice to standard chow. RESULTS: When exposed to the HFD, both lines significantly decreased their FI (MH, 40% to 45%; ML, 31% to 35%). This decrease occurred simultaneously with a significant increase in apparent energy absorption efficiency (AEAE). When returned to chow, FI and AEAE returned to the levels observed prior to HFD exposure. Because of the adjustments in FI, the absorbed energy was maintained in the MLs and, thus, body mass remained constant. The MH individuals overcompensated for the elevated energy content and AEAE on the HFD and, therefore, absorbed lower energy than when feeding on chow. These mice also did not significantly change their body mass when on the HFD and must have made adjustments in their energy expenditures. Both lines and both sexes increased in fat content on the HFD, but these effects were not different between lines or sexes. DISCUSSION: We found no support for the hypothesis that mice with low RMRs were more susceptible to weight gain when fed the HFD. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15833941/Mice_with_low_metabolic_rates_are_not_susceptible_to_weight_gain_when_fed_a_high_fat_diet_ L2 - https://doi.org/10.1038/oby.2005.59 DB - PRIME DP - Unbound Medicine ER -