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Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina.
J Med Virol. 2005 Jun; 76(2):285-9.JM

Abstract

Lymphocytic choriomeningitis virus (LCMV) is the prototype of the family Arenaviridae and is associated with the natural reservoir, Mus domesticus (Md). It causes meningitis and a flu-like illness characterized by malaise, myalgia, retrorbital headache, and photophobia. This study presents the data obtained in a rodent and human serological study during 6 years (1998-2003) in the city of Rio Cuarto, Argentina. Antibodies anti-LCMV were sought by ELISA in rodents and humans. LCMV was found only in Md species in 9.4% of animals. The results also show some seasonal, no significant variations in the prevalence of the infection. Distribution of positive mice was not modified significantly by trapping sites, sex, or age of the animals. The prevalence of LCMV positive urban residents was found to be consistently low (1-3.6%) along the study period, with overage prevalence of 3.3% and values in males (4.6%) significantly higher than in females (2.6%) (P < 0.05). Seven of 432 pregnant women were found to be LCMV positive, but the absence of LCMV antibodies in the newborns demonstrated that the mothers were infected before pregnancy. This study is the first evidence on endemic LCMV in an Argentine city located outside the endemic area of Argentine hemorrhagic fever (AHF) and described the need to study other areas and increase awareness of this viral infection.

Authors+Show Affiliations

Instituto Nacional de Enfermedades Virales Humanas "Dr. Julio I. Maiztegui", Pergamino BA, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15834871

Citation

Riera, Laura, et al. "Serological Study of the Lymphochoriomeningitis Virus (LCMV) in an Inner City of Argentina." Journal of Medical Virology, vol. 76, no. 2, 2005, pp. 285-9.
Riera L, Castillo E, Del Carmen Saavedra M, et al. Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina. J Med Virol. 2005;76(2):285-9.
Riera, L., Castillo, E., Del Carmen Saavedra, M., Priotto, J., Sottosanti, J., Polop, J., & Ambrosio, A. M. (2005). Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina. Journal of Medical Virology, 76(2), 285-9.
Riera L, et al. Serological Study of the Lymphochoriomeningitis Virus (LCMV) in an Inner City of Argentina. J Med Virol. 2005;76(2):285-9. PubMed PMID: 15834871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina. AU - Riera,Laura, AU - Castillo,Ernesto, AU - Del Carmen Saavedra,María, AU - Priotto,José, AU - Sottosanti,Josefa, AU - Polop,Jaime, AU - Ambrosio,Ana María, PY - 2005/4/19/pubmed PY - 2005/9/17/medline PY - 2005/4/19/entrez SP - 285 EP - 9 JF - Journal of medical virology JO - J Med Virol VL - 76 IS - 2 N2 - Lymphocytic choriomeningitis virus (LCMV) is the prototype of the family Arenaviridae and is associated with the natural reservoir, Mus domesticus (Md). It causes meningitis and a flu-like illness characterized by malaise, myalgia, retrorbital headache, and photophobia. This study presents the data obtained in a rodent and human serological study during 6 years (1998-2003) in the city of Rio Cuarto, Argentina. Antibodies anti-LCMV were sought by ELISA in rodents and humans. LCMV was found only in Md species in 9.4% of animals. The results also show some seasonal, no significant variations in the prevalence of the infection. Distribution of positive mice was not modified significantly by trapping sites, sex, or age of the animals. The prevalence of LCMV positive urban residents was found to be consistently low (1-3.6%) along the study period, with overage prevalence of 3.3% and values in males (4.6%) significantly higher than in females (2.6%) (P < 0.05). Seven of 432 pregnant women were found to be LCMV positive, but the absence of LCMV antibodies in the newborns demonstrated that the mothers were infected before pregnancy. This study is the first evidence on endemic LCMV in an Argentine city located outside the endemic area of Argentine hemorrhagic fever (AHF) and described the need to study other areas and increase awareness of this viral infection. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/15834871/Serological_study_of_the_lymphochoriomeningitis_virus__LCMV__in_an_inner_city_of_Argentina_ L2 - https://doi.org/10.1002/jmv.20357 DB - PRIME DP - Unbound Medicine ER -