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Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure.
Clin Exp Hypertens. 2005 Feb-Apr; 27(2-3):139-47.CE

Abstract

Recent reports suggest the relationship of short-term blood pressure (BP) variability to cardiovascular target organ damage. In this study, short-term BP variability was assessed as the standard deviation of daytime and nighttime BP in 36 hospitalized patients with chronic renal failure (CRF) who underwent ambulatory BP monitoring. Positive correlations were observed between body mass index (BMI) and daytime systolic and diastolic BP variability, BMI and nighttime diastolic BP variability, cholesterol and daytime systolic BP variability, cholesterol and nighttime systolic and diastolic BP variability, nocturnal decline in BP and nighttime diastolic BP variability, and plasma concentration of norepinephrine (p-NE) and nighttime systolic BP variability. In multivariate linear regression analyses, BMI showed the strongest association with daytime and nighttime diastolic BP variability (p < .005 and p < .05). On the other hand, cholesterol and p-NE were the primary determinants of daytime and nighttime systolic BP variability, respectively (p < .01 and p < .0005). Interestingly, CRF patients with ischemic heart disease (IHD) had significantly increased daytime systolic and diastolic BP variability and nighttime systolic BP variability (p < .05 or less). Furthermore, logistic regression analysis demonstrated that nighttime systolic BP variability was an independent risk factor of IHD in patients with CRF (odds ratio 1.50 [95% confidence interval 1.01 to 2.25]; p < .05). Taken together, short-term BP variability is suggested to be affected by BMI, cholesterol, and p-NE in CRF patients. Furthermore, sympathetic nerve overactivity may be involved in cardiovascular complications in CRF patients through the increase in nighttime systolic BP variability.

Authors+Show Affiliations

Sakai M
Department of Medicine II, Yokohama City University School of Medicine, Yokohama, Japan.
Tamura K
No affiliation info available
Tanaka Y
No affiliation info available
Tsurumi Y
No affiliation info available
Okano Y
No affiliation info available
Koide Y
No affiliation info available
Endoh T
No affiliation info available
Matsushita K
No affiliation info available
Kihara M
No affiliation info available
Hirawa N
No affiliation info available
Toya Y
No affiliation info available
Tokita Y
No affiliation info available
Ohnishi T
No affiliation info available
Umemura S
No affiliation info available

MeSH

AgedBiomarkersBlood PressureBlood Pressure Monitoring, AmbulatoryBody Mass IndexCholesterolCircadian RhythmFemaleHumansHypertensionKidney Failure, ChronicMaleMiddle AgedMyocardial IschemiaNorepinephrineOdds RatioPrognosisRisk Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15835376

Citation

Sakai, Masashi, et al. "Analysis of Factors That Affect Short-term Blood Pressure Variability in Patients With Chronic Renal Failure." Clinical and Experimental Hypertension (New York, N.Y. : 1993), vol. 27, no. 2-3, 2005, pp. 139-47.
Sakai M, Tamura K, Tanaka Y, et al. Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure. Clin Exp Hypertens. 2005;27(2-3):139-47.
Sakai, M., Tamura, K., Tanaka, Y., Tsurumi, Y., Okano, Y., Koide, Y., Endoh, T., Matsushita, K., Kihara, M., Hirawa, N., Toya, Y., Tokita, Y., Ohnishi, T., & Umemura, S. (2005). Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure. Clinical and Experimental Hypertension (New York, N.Y. : 1993), 27(2-3), 139-47.
Sakai M, et al. Analysis of Factors That Affect Short-term Blood Pressure Variability in Patients With Chronic Renal Failure. Clin Exp Hypertens. 2005 Feb-Apr;27(2-3):139-47. PubMed PMID: 15835376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of factors that affect short-term blood pressure variability in patients with chronic renal failure. AU - Sakai,Masashi, AU - Tamura,Kouichi, AU - Tanaka,Yutaka, AU - Tsurumi,Yuko, AU - Okano,Yasuko, AU - Koide,Yuichi, AU - Endoh,Teruhiko, AU - Matsushita,Kei, AU - Kihara,Minoru, AU - Hirawa,Nobuhito, AU - Toya,Yoshiyuki, AU - Tokita,Yasuo, AU - Ohnishi,Toshimasa, AU - Umemura,Satoshi, PY - 2005/4/20/pubmed PY - 2005/7/8/medline PY - 2005/4/20/entrez SP - 139 EP - 47 JF - Clinical and experimental hypertension (New York, N.Y. : 1993) JO - Clin Exp Hypertens VL - 27 IS - 2-3 N2 - Recent reports suggest the relationship of short-term blood pressure (BP) variability to cardiovascular target organ damage. In this study, short-term BP variability was assessed as the standard deviation of daytime and nighttime BP in 36 hospitalized patients with chronic renal failure (CRF) who underwent ambulatory BP monitoring. Positive correlations were observed between body mass index (BMI) and daytime systolic and diastolic BP variability, BMI and nighttime diastolic BP variability, cholesterol and daytime systolic BP variability, cholesterol and nighttime systolic and diastolic BP variability, nocturnal decline in BP and nighttime diastolic BP variability, and plasma concentration of norepinephrine (p-NE) and nighttime systolic BP variability. In multivariate linear regression analyses, BMI showed the strongest association with daytime and nighttime diastolic BP variability (p < .005 and p < .05). On the other hand, cholesterol and p-NE were the primary determinants of daytime and nighttime systolic BP variability, respectively (p < .01 and p < .0005). Interestingly, CRF patients with ischemic heart disease (IHD) had significantly increased daytime systolic and diastolic BP variability and nighttime systolic BP variability (p < .05 or less). Furthermore, logistic regression analysis demonstrated that nighttime systolic BP variability was an independent risk factor of IHD in patients with CRF (odds ratio 1.50 [95% confidence interval 1.01 to 2.25]; p < .05). Taken together, short-term BP variability is suggested to be affected by BMI, cholesterol, and p-NE in CRF patients. Furthermore, sympathetic nerve overactivity may be involved in cardiovascular complications in CRF patients through the increase in nighttime systolic BP variability. SN - 1064-1963 UR - https://www.unboundmedicine.com/medline/citation/15835376/Analysis_of_factors_that_affect_short_term_blood_pressure_variability_in_patients_with_chronic_renal_failure_ DB - PRIME DP - Unbound Medicine ER -