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Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL.
Clin Exp Hypertens. 2005 Feb-Apr; 27(2-3):169-78.CE

Abstract

Increased resting heart rate (HR) and increased sympathetic nervous activity are independent risk factors for cardiovascular disease. Recently, base heart rate (HRo: minimum stable HR during sleep) has been reported to relate to cardiac stroke volume and age. However, little is known about the relevance of HRo. The aim of our study was to evaluate how HRo is associated with HR variability (HRV), blood pressure and health-related quality of life (HRQOL) in healthy subjects. A total of 139 volunteers participated in this study that measured 24-hr HR, HRV, and blood pressure. HRo was estimated from the trendgram and the histogram of HR during the nighttime (sleep) period, and calculated as the 1% lowest value of its integral. HRQOL was assessed by Medical Outcome Study Short-Forum 36-Item Health Survey. Sympathetic nervous activity (ratio of low frequency to high frequency component: LF/HF) and parasympathetic nervous activity (high frequency component: HF) were calculated by ECG monitoring. HRo was positively correlated with 24-hr LF/HF and nighttime LF/HF. HRo was negatively correlated with 24-hr HF and nighttime HF. Moreover, HRo was positively correlated with the scores of social functioning and role-physical. Using multivariate analysis, HRo is related to LF/HF, body mass index, and the score of social functioning (HRQOL). HRo may be a useful indicator for assessing sympathetic nervous activity and HRQOL in normotensive healthy subjects.

Authors+Show Affiliations

Okano Y
Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama City, Japan.
Hirawa N
No affiliation info available
Matsushita K
No affiliation info available
Tamura K
No affiliation info available
Kihara M
No affiliation info available
Toya Y
No affiliation info available
Tochikubo O
No affiliation info available
Umemura S
No affiliation info available

MeSH

AdultAutonomic Nervous SystemBlood PressureBlood Pressure Monitoring, AmbulatoryCircadian RhythmElectrocardiography, AmbulatoryFemaleHealth StatusHeart RateHumansMaleMultivariate AnalysisQuality of LifeReference ValuesRestSleepSurveys and Questionnaires

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15835379

Citation

Okano, Yasuko, et al. "Implication of Base Heart Rate in Autonomic Nervous Function, Blood Pressure and Health-related QOL." Clinical and Experimental Hypertension (New York, N.Y. : 1993), vol. 27, no. 2-3, 2005, pp. 169-78.
Okano Y, Hirawa N, Matsushita K, et al. Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL. Clin Exp Hypertens. 2005;27(2-3):169-78.
Okano, Y., Hirawa, N., Matsushita, K., Tamura, K., Kihara, M., Toya, Y., Tochikubo, O., & Umemura, S. (2005). Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL. Clinical and Experimental Hypertension (New York, N.Y. : 1993), 27(2-3), 169-78.
Okano Y, et al. Implication of Base Heart Rate in Autonomic Nervous Function, Blood Pressure and Health-related QOL. Clin Exp Hypertens. 2005 Feb-Apr;27(2-3):169-78. PubMed PMID: 15835379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Implication of base heart rate in autonomic nervous function, blood pressure and health-related QOL. AU - Okano,Yasuko, AU - Hirawa,Nobuhito, AU - Matsushita,Kei, AU - Tamura,Kouichi, AU - Kihara,Minoru, AU - Toya,Yoshiyuki, AU - Tochikubo,Osamu, AU - Umemura,Satoshi, PY - 2005/4/20/pubmed PY - 2005/7/8/medline PY - 2005/4/20/entrez SP - 169 EP - 78 JF - Clinical and experimental hypertension (New York, N.Y. : 1993) JO - Clin Exp Hypertens VL - 27 IS - 2-3 N2 - Increased resting heart rate (HR) and increased sympathetic nervous activity are independent risk factors for cardiovascular disease. Recently, base heart rate (HRo: minimum stable HR during sleep) has been reported to relate to cardiac stroke volume and age. However, little is known about the relevance of HRo. The aim of our study was to evaluate how HRo is associated with HR variability (HRV), blood pressure and health-related quality of life (HRQOL) in healthy subjects. A total of 139 volunteers participated in this study that measured 24-hr HR, HRV, and blood pressure. HRo was estimated from the trendgram and the histogram of HR during the nighttime (sleep) period, and calculated as the 1% lowest value of its integral. HRQOL was assessed by Medical Outcome Study Short-Forum 36-Item Health Survey. Sympathetic nervous activity (ratio of low frequency to high frequency component: LF/HF) and parasympathetic nervous activity (high frequency component: HF) were calculated by ECG monitoring. HRo was positively correlated with 24-hr LF/HF and nighttime LF/HF. HRo was negatively correlated with 24-hr HF and nighttime HF. Moreover, HRo was positively correlated with the scores of social functioning and role-physical. Using multivariate analysis, HRo is related to LF/HF, body mass index, and the score of social functioning (HRQOL). HRo may be a useful indicator for assessing sympathetic nervous activity and HRQOL in normotensive healthy subjects. SN - 1064-1963 UR - https://www.unboundmedicine.com/medline/citation/15835379/Implication_of_base_heart_rate_in_autonomic_nervous_function_blood_pressure_and_health_related_QOL_ DB - PRIME DP - Unbound Medicine ER -