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Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial.
J Intern Med. 2005 May; 257(5):438-45.JI

Abstract

OBJECTIVES

The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients.

DESIGN AND SETTING

This double-blind randomised placebo-controlled trial was performed at the dialysis department of a non-university hospital. SUBJECTS, INTERVENTION AND MEASUREMENTS: A total of 44 clinically stable, non-diabetic patients on dialysis therapy (23 on haemo- and 21 on peritoneal-dialysis) without manifest cardiovascular disease were included in this study. They were randomised for treatment during a period of 12 weeks with 40 mg atorvastatin + placebo alpha-tocopherol (group 1) once daily, 800 IU alpha-tocopherol + placebo atorvastatin once daily (group 2), 40 mg atorvastatin + 800 IU alpha-tocopherol once daily (group 3), or placebo atorvastatin + placebo alpha-tocopherol once daily (group 4). Assessment of lipid profile and oxidative stress was performed at the start of the study and after 12 weeks of treatment.

RESULTS

Treatment with atorvastatin reduced total cholesterol, triglycerides (TG), low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB) and levels of oxidised LDL (oxLDL) with 30-43%. It had no influence on LDL oxidisability. Additional supplementation with alpha-tocopherol had no effect on lipid profile and oxLDL levels but decreased in vitro LDL oxidisability. No side-effects were observed.

CONCLUSIONS

Treatment with atorvastatin is effective in lowering plasma total cholesterol, TG, LDL, apoB and oxLDL in a population of stable dialysis patients and might therefore be an effective tool in improving the poor cardiovascular outcome in these patients. Supplementation of alpha-tocopherol to atorvastatin had beneficial effects on in vitro LDL oxidisability and might therefore be of additional value. Further research on the clinical effects of treatment with atorvastatin in combination with alpha-tocopherol is necessary.

Authors+Show Affiliations

Department of Internal Medicine, Isala Clinics, location Weezenlanden, Zwolle, The Netherlands. s.diepeveen@nier.umcn.nl <s.diepeveen@nier.umcn.nl>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15836660

Citation

Diepeveen, S H A., et al. "Effects of Atorvastatin and Vitamin E On Lipoproteins and Oxidative Stress in Dialysis Patients: a Randomised-controlled Trial." Journal of Internal Medicine, vol. 257, no. 5, 2005, pp. 438-45.
Diepeveen SH, Verhoeven GW, Van Der Palen J, et al. Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial. J Intern Med. 2005;257(5):438-45.
Diepeveen, S. H., Verhoeven, G. W., Van Der Palen, J., Dikkeschei, L. D., Van Tits, L. J., Kolsters, G., Offerman, J. J., Bilo, H. J., & Stalenhoef, A. F. (2005). Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial. Journal of Internal Medicine, 257(5), 438-45.
Diepeveen SH, et al. Effects of Atorvastatin and Vitamin E On Lipoproteins and Oxidative Stress in Dialysis Patients: a Randomised-controlled Trial. J Intern Med. 2005;257(5):438-45. PubMed PMID: 15836660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial. AU - Diepeveen,S H A, AU - Verhoeven,G W H E, AU - Van Der Palen,J, AU - Dikkeschei,L D, AU - Van Tits,L J, AU - Kolsters,G, AU - Offerman,J J G, AU - Bilo,H J G, AU - Stalenhoef,A F H, PY - 2005/4/20/pubmed PY - 2005/5/27/medline PY - 2005/4/20/entrez SP - 438 EP - 45 JF - Journal of internal medicine JO - J. Intern. Med. VL - 257 IS - 5 N2 - OBJECTIVES: The objective of this study was to examine the effects of treatment with atorvastatin, alpha-tocopherol and the combination of both, on lipoproteins and oxidative stress in dialysis patients. DESIGN AND SETTING: This double-blind randomised placebo-controlled trial was performed at the dialysis department of a non-university hospital. SUBJECTS, INTERVENTION AND MEASUREMENTS: A total of 44 clinically stable, non-diabetic patients on dialysis therapy (23 on haemo- and 21 on peritoneal-dialysis) without manifest cardiovascular disease were included in this study. They were randomised for treatment during a period of 12 weeks with 40 mg atorvastatin + placebo alpha-tocopherol (group 1) once daily, 800 IU alpha-tocopherol + placebo atorvastatin once daily (group 2), 40 mg atorvastatin + 800 IU alpha-tocopherol once daily (group 3), or placebo atorvastatin + placebo alpha-tocopherol once daily (group 4). Assessment of lipid profile and oxidative stress was performed at the start of the study and after 12 weeks of treatment. RESULTS: Treatment with atorvastatin reduced total cholesterol, triglycerides (TG), low-density lipoprotein (LDL) cholesterol, apolipoprotein B (apoB) and levels of oxidised LDL (oxLDL) with 30-43%. It had no influence on LDL oxidisability. Additional supplementation with alpha-tocopherol had no effect on lipid profile and oxLDL levels but decreased in vitro LDL oxidisability. No side-effects were observed. CONCLUSIONS: Treatment with atorvastatin is effective in lowering plasma total cholesterol, TG, LDL, apoB and oxLDL in a population of stable dialysis patients and might therefore be an effective tool in improving the poor cardiovascular outcome in these patients. Supplementation of alpha-tocopherol to atorvastatin had beneficial effects on in vitro LDL oxidisability and might therefore be of additional value. Further research on the clinical effects of treatment with atorvastatin in combination with alpha-tocopherol is necessary. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/15836660/Effects_of_atorvastatin_and_vitamin_E_on_lipoproteins_and_oxidative_stress_in_dialysis_patients:_a_randomised_controlled_trial_ L2 - https://doi.org/10.1111/j.1365-2796.2005.01484.x DB - PRIME DP - Unbound Medicine ER -